Homo‐ and heteroleptic phototoxic dinuclear metallo‐intercalators based on Ru II(dppn) intercalating moieties: synthesis, optical and biological studies.

Journal article


Saeed, Hiwa K., Jarman, Paul J., Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim Q., Mckenzie, Luke K., Weinstein, Julia A., Buurma, Niklaas J., Smythe, Carl G. W. and Thomas, Jim A. 2017. Homo‐ and heteroleptic phototoxic dinuclear metallo‐intercalators based on Ru II(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201707350
AuthorsSaeed, Hiwa K., Jarman, Paul J., Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim Q., Mckenzie, Luke K., Weinstein, Julia A., Buurma, Niklaas J., Smythe, Carl G. W. and Thomas, Jim A.
Abstract

Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.

KeywordsOrganometallic chemistry; Photochemistry; Bioinorganic chemistry; Dna
Year2017
JournalAngewandte Chemie International Edition
PublisherWiley
ISSN1433-7851
Digital Object Identifier (DOI)https://doi.org/10.1002/anie.201707350
Web address (URL)http://hdl.handle.net/10545/623058
hdl:10545/623058
Publication dates27 Sep 2017
Publication process dates
Deposited18 Oct 2018, 15:58
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Archived with thanks to Angewandte Chemie International Edition

ContributorsUniversity of Sheffield, Cardiff University, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Physical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Physical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK, Department of Biomedical Science; University of Sheffield; Sheffield S10 2TN UK and Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK
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