Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

Journal article

Adaikalakoteswari, A, Finer, S, Voyias, P.D, McCarthy, C.M, Vatish, M, Moore, J, Smart-Halajko, M, Bawazeer, N, Al-Daghri, N.M, McTernan, P.G and Kumar, S 2015. Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics. https://doi.org/10.1186/s13148-015-0046-8
AuthorsAdaikalakoteswari, A, Finer, S, Voyias, P.D, McCarthy, C.M, Vatish, M, Moore, J, Smart-Halajko, M, Bawazeer, N, Al-Daghri, N.M, McTernan, P.G and Kumar, S
Abstract

The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B12 deficiency is associated with altered lipid profile and play an important role in the prediction of metabolic risk, however, as of yet, no direct mechanism has been investigated to confirm this.

Year2015
JournalClinical Epigenetics
PublisherBMC
ISSN18687083
Digital Object Identifier (DOI)https://doi.org/10.1186/s13148-015-0046-8
Web address (URL)http://hdl.handle.net/10545/624094
hdl:10545/624094
Publication dates27 Feb 2015
Publication process dates
Deposited09 Aug 2019, 08:50
ContributorsUniversity of Warwick
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https://repository.derby.ac.uk/item/925ww/vitamin-b12-insufficiency-induces-cholesterol-biosynthesis-by-limiting-s-adenosylmethionine-and-modulating-the-methylation-of-srebf1-and-ldlr-genes

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