Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.
Journal article
Authors | Fretwell, Laurice, Woolard, Jeanette and Carter, Joanne |
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Abstract | VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effects in conscious rats. Male Sprague Dawley rats (350-450 g) were chronically implanted with pulsed Doppler flow probes (renal and mesenteric arteries, and the descending abdominal aorta) and catheters (jugular vein, peritoneal cavity, and distal abdominal aorta). Regional hemodynamics were measured over 4 d, before and after daily administration of cediranib (3 and 6 mg/kg, 3 and 6 mg/kg/h for 1 h, i.v.), sorafenib (10 and 20 mg/kg, 10 and 20 mg kg/h for 1 h, i.v.), pazopanib (30 and100 mg/kg, i.p.), or vandetanib (12.5 and 25 mg/kg, i.p.). All drugs evoked significant increases. |
Keywords | Cancer therapy; RKTI; VEGF; Hypertension; Regional haemodynamics |
Year | 2016 |
Journal | The FASEB Journal |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology | |
Publisher | FASEB |
ISSN | 1530-6860 |
Digital Object Identifier (DOI) | https://doi.org/10.1096/fj.201600749R |
Web address (URL) | http://hdl.handle.net/10545/623515 |
hdl:10545/623515 | |
Publication dates | 16 Dec 2016 |
Publication process dates | |
Deposited | 21 Feb 2019, 16:27 |
Accepted | 03 Dec 2016 |
Contributors | De Montfort University, Leicester and University of Nottingham |
File | File Access Level Open |
File | File Access Level Open |
https://repository.derby.ac.uk/item/94922/effects-of-4-multitargeted-receptor-tyrosine-kinase-inhibitors-on-regional-hemodynamics-in-conscious-freely-moving-rats
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