Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer
Journal article
Authors | Althobiti, M., El-sharawy, K. A., Joseph, C., Aleskandarany, M., Toss, M. S., Green, A. R. and Rakha, E. A. |
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Abstract | Purpose: The outcome of the luminal oestrogen receptor-positive (ER +) subtype of breast cancer (BC) is highly variable and patient stratification needs to be refined. We assessed the prognostic significance of oestrogen-regulated solute carrier family 39 member 6 (SLC39A6) in BC, with emphasis on ER + tumours. Materials and methods: SLC39A6 mRNA expression and copy number alterations were assessed using the METABRIC cohort (n = 1980). SLC39A6 protein expression was evaluated in a large (n = 670) and annotated series of early-stage (I-III) operable BC using tissue microarrays and immunohistochemistry. The associations between SLC39A6 expression and clinicopathological parameters, patient outcomes and other ER-related markers were evaluated using Chi-square tests and Kaplan-Meier curves. Results: High SLC39A6 mRNA and protein expression was associated with features characteristic of less aggressive tumours in the entire BC cohort and ER + subgroup. SLC39A6 protein expression was detected in the cytoplasm and nuclei of the tumour cells. High SLC39A6 nuclear expression and mRNA levels were positively associated with ER + tumours and expression of ER-related markers, including the progesterone receptor, forkhead box protein A1 and GATA binding protein 3. In the ER + luminal BC, high SLC39A6 expression was independently associated with longer BC-specific survival (BCSS) (P = 0.015, HR 0.678, 95% CI 0.472‒0.972) even in those who did not receive endocrine therapy (P = 0.001, HR 0.701, 95% CI 0.463‒1.062). Conclusion: SLC39A6 may be prognostic for a better outcome in ER + luminal BC. Further functional studies to investigate the role of SLC39A6 in ER + luminal BC are warranted. |
Keywords | ER-positive breast cancer; ER-related marker; Prognosis; SLC39A6 |
Year | 2021 |
Journal | Breast Cancer Research and Treatment |
Journal citation | 189 (3), pp. 621-630 |
Publisher | Springer |
ISSN | 1573-7217 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s10549-021-06336-y |
Web address (URL) | https://link.springer.com/article/10.1007/s10549-021-06336-y |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 28 Aug 2021 |
Publication process dates | |
Accepted | 15 Jul 2021 |
Deposited | 05 Nov 2024 |
Supplemental file | File Access Level Open |
https://repository.derby.ac.uk/item/9z069/oestrogen-regulated-protein-slc39a6-a-biomarker-of-good-prognosis-in-luminal-breast-cancer
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