Machine Learning Assisted Doppler Features for Enhancing Thyroid Cancer Diagnosis

Journal article


Zhu, Y., Du, H., Jiang, Q., Zhang, T., Huang, X., Zhang, Y., Shi, X., Shan, J. and AlZoubi, A. 2021. Machine Learning Assisted Doppler Features for Enhancing Thyroid Cancer Diagnosis. Journal of Ultrasound in Medicine. 41 (8), pp. 1961-1974. https://doi.org/10.1002/jum.15873
AuthorsZhu, Y., Du, H., Jiang, Q., Zhang, T., Huang, X., Zhang, Y., Shi, X., Shan, J. and AlZoubi, A.
Abstract

Background

This pilot study aims at exploiting machine learning techniques to extract color Doppler ultrasound (CDUS) features and to build an artificial neural network (ANN) model based on these CDUS features for improving the diagnostic performance of thyroid cancer classification.
Methods

A total of 674 patients with 712 thyroid nodules (TNs) (512 from internal dataset and 200 from external dataset) were randomly selected in this retrospective study. We used ANN to build a model (TDUS-Net) for classifying malignant and benign TNs using both the automatically extracted quantitative CDUS features (whole ratio, intranodular ratio, peripheral ratio, and number of vessels) and gray-scale ultrasound (US) features defined by the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS). Then, we compared the diagnostic performance of the model, the performance of another ANN model based on the gray-scale US features alone (TUS-Net), and that of radiologists.
Results

The TDUS-Net (0.898, 95% CI: 0.868–0.922) achieved a higher area under the curve (AUC) than that of TUS-Net (0.881, 95% CI: 0.850–0.908) in the internal tests. Compared with radiologists, TDUS-Net (AUC: 0.925, 95% CI: 0.880–0.958) performed better than radiologists (AUC: 0.810, 95% CI: 0.749–0.862) in the external tests.
Conclusions

Applying a machine learning model by combining both gray-scale US features and CDUS features can achieve comparable or even higher performance than radiologists in classifying TNs.

Keywordsmachine learning techniques; color Doppler ultrasound (CDUS) ; radiologists
Year2021
JournalJournal of Ultrasound in Medicine
Journal citation41 (8), pp. 1961-1974
PublisherWiley
ISSN1550-9613
Digital Object Identifier (DOI)https://doi.org/10.1002/jum.15873
Web address (URL)https://bear.buckingham.ac.uk/532/
https://onlinelibrary.wiley.com/doi/abs/10.1002/jum.15873
Output statusPublished
Publication dates
Online09 Nov 2021
Publication process dates
Accepted24 Oct 2021
Deposited25 Jul 2024
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https://repository.derby.ac.uk/item/q77yv/machine-learning-assisted-doppler-features-for-enhancing-thyroid-cancer-diagnosis

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