Bio-vehicles of cytotoxic drugs for delivery to tumour specific targets for cancer precision therapy

Journal article


Al-mansoori, Layla, Elsinga, Philip and Goda, Sayed K. 2021. Bio-vehicles of cytotoxic drugs for delivery to tumour specific targets for cancer precision therapy. Biomedicine & Pharmacotherapy. 144, p. 112260. https://doi.org/10.1016/j.biopha.2021.112260
AuthorsAl-mansoori, Layla, Elsinga, Philip and Goda, Sayed K.
Abstract

Abnormal structural and molecular changes in malignant tissues were thoroughly investigated and utilized to target tumor cells, hence rescuing normal healthy tissues and lowering the unwanted side effects as non-specific cytotoxicity. Various ligands for cancer cell specific markers have been uncovered and inspected for directional delivery of the anti-cancer drug to the tumor site, in addition to diagnostic applications. Over the past few decades research related to the ligand targeted therapy (LTT) increased tremendously aiming to treat various pathologies, mainly cancers with well exclusive markers. Malignant tumors are known to induce elevated levels of a variety of proteins and peptides known as cancer “markers” as certain antigens (e.g., Prostate specific membrane antigen “PSMA”, carcinoembryonic antigen “CEA”), receptors (folate receptor, somatostatin receptor), integrins (Integrin αvβ3) and cluster of differentiation molecules (CD13). The choice of an appropriate marker to be targeted and the design of effective ligand-drug conjugate all has to be carefully selected to generate the required therapeutic effect. Moreover, since some tumors express aberrantly high levels of more than one marker, some approaches investigated targeting cancer cells with more than one ligand (dual or multi targeting). We aim in this review to report an update on the cancer-specific receptors and the vehicles to deliver cytotoxic drugs, including recent advancements on nano delivery systems and their implementation in targeted cancer therapy. We will discuss the advantages and limitations facing this approach and possible solutions to mitigate these obstacles. To achieve the said aim a literature search in electronic data bases (PubMed and others) using keywords “Cancer specific receptors, cancer specific antibody, tumor specific peptide carriers, cancer overexpressed proteins, gold nanotechnology and gold nanoparticles in cancer treatment” was carried out.

KeywordsPharmacology; General Medicine
Year2021
JournalBiomedicine & Pharmacotherapy
Journal citation144, p. 112260
PublisherElsevier BV
ISSN0753-3322
Digital Object Identifier (DOI)https://doi.org/10.1016/j.biopha.2021.112260
Web address (URL)http://hdl.handle.net/10545/626193
https://www.elsevier.com/tdm/userlicense/1.0/
http://creativecommons.org/licenses/by/4.0/
hdl:10545/626193
Publication dates01 Oct 2021
Publication process dates
Deposited13 Jan 2022, 09:33
Accepted26 Sep 2021
Rights

© 2021 The Author(s). Published by Elsevier Masson SAS.

Attribution 4.0 International

ContributorsQatar University, Doha, Qatar, University Medical Center Groningen, the Netherlands, Cairo University, Egypt and University of Derby
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https://repository.derby.ac.uk/item/94q6y/bio-vehicles-of-cytotoxic-drugs-for-delivery-to-tumour-specific-targets-for-cancer-precision-therapy

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