The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line.

Journal article


Asher, Viren, Warren, Averil, Shaw, Robert, Sowter, Heidi M., Bali, Anish and Khan, Raheela 2011. The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer cell international. https://doi.org/10.1186/1475-2867-11-6
AuthorsAsher, Viren, Warren, Averil, Shaw, Robert, Sowter, Heidi M., Bali, Anish and Khan, Raheela
Abstract

The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by which Eag and HERG channels affect cell proliferation in ovarian cancer cells is required and therefore we investigated their role in cell proliferation and their effect on the cell cycle and apoptosis of ovarian cancer cells.

KeywordsOvarian cancer; Potassium channels; Eag1
Year2011
JournalCancer cell international
ISSN1475-2867
Digital Object Identifier (DOI)https://doi.org/10.1186/1475-2867-11-6
Web address (URL)http://hdl.handle.net/10545/225603
hdl:10545/225603
Publication datesMar 2011
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Deposited23 May 2012, 14:50
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Archived with thanks to Cancer cell international

ContributorsRoyal Derby Hospital, School of Graduate Entry Medicine and Health and University of Derby, Faculty of Education, Health and Science
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https://repository.derby.ac.uk/item/950x2/the-role-of-eag-and-herg-channels-in-cell-proliferation-and-apoptotic-cell-death-in-sk-ov-3-ovarian-cancer-cell-line

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