The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line.

Journal article

Asher, Viren, Warren, Averil, Shaw, Robert, Sowter, Heidi M., Bali, Anish and Khan, Raheela 2011. The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer cell international. https://doi.org/10.1186/1475-2867-11-6
AuthorsAsher, Viren, Warren, Averil, Shaw, Robert, Sowter, Heidi M., Bali, Anish and Khan, Raheela
Abstract

The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by which Eag and HERG channels affect cell proliferation in ovarian cancer cells is required and therefore we investigated their role in cell proliferation and their effect on the cell cycle and apoptosis of ovarian cancer cells.

KeywordsOvarian cancer; Potassium channels; Eag1
Year2011
JournalCancer cell international
ISSN1475-2867
Digital Object Identifier (DOI)https://doi.org/10.1186/1475-2867-11-6
Web address (URL)http://hdl.handle.net/10545/225603
hdl:10545/225603
Publication datesMar 2011
Publication process dates
Deposited23 May 2012, 14:50
Rights

Archived with thanks to Cancer cell international

ContributorsRoyal Derby Hospital, School of Graduate Entry Medicine and Health and University of Derby, Faculty of Education, Health and Science
File
File Access Level
Open
File
File Access Level
Open
File
File Access Level
Open
File
File Access Level
Open
Permalink -

https://repository.derby.ac.uk/item/950x2/the-role-of-eag-and-herg-channels-in-cell-proliferation-and-apoptotic-cell-death-in-sk-ov-3-ovarian-cancer-cell-line

Log in to edit

Download files

  • 31
    total views
  • 10
    total downloads
  • 4
    views this month
  • 0
    downloads this month

Export as

Related outputs

The PAX8 cistrome in epithelial ovarian cancer.
Adler, Emily K., Corona, Rosario I., Lee, Janet M., Rodriguez-Malave, Norma, Mhawech-Fauceglia, Paulette, Sowter, Heidi M., Hazelett, Dennis J., Lawrenson, Kate and Gayther, Simon A. 2017. The PAX8 cistrome in epithelial ovarian cancer. Oncotarget. https://doi.org/10.18632/oncotarget.22718
Targeting Src in endometriosis-associated ovarian cancer
Manek, Roxanne, Pakzamir, Elham, Mhawech-Fauceglia, Paulette, Pejovic, Tanja, Sowter, Heidi M., Gayther, Simon A. and Lawrenson, Kate 2016. Targeting Src in endometriosis-associated ovarian cancer. Oncogenesis. https://doi.org/10.1038/oncsis.2016.54
Pilot study : can inspiratory muscle training relieve symptoms ff dyspnoea and improve quality of life for advanced cancer patients ?: 1872 Board #24 June 2, 3: 30 PM - 5: 00 PM.
Lindley, Martin R., Faghy, Mark, Sowter, Heidi M. and Mickleborough, Timothy D. 2016. Pilot study : can inspiratory muscle training relieve symptoms ff dyspnoea and improve quality of life for advanced cancer patients ?: 1872 Board #24 June 2, 3: 30 PM - 5: 00 PM. Wolters Kluwer. https://doi.org/10.1249/01.mss.0000486545.72377.ea
"I'm 100% for it! I'm a convert!" Women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis
Archer, Stephanie, Phillips, Elly, Montague, Jane, Bali, Anish and Sowter, Heidi M. 2014. "I'm 100% for it! I'm a convert!" Women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis. Complementary therapies in medicine. https://doi.org/10.1016/j.ctim.2014.12.003
"I'm 100% for it! I'm a convert!": Women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis.
Archer, Stephanie, Phillips, Elly, Montague, Jane, Bali, Anish and Sowter, Heidi M. 2015. "I'm 100% for it! I'm a convert!": Women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis. Complementary therapies in medicine. https://doi.org/10.1016/j.ctim.2014.12.003
Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the Secretomes of three-dimensional genetic models of ovarian carcinogenesis.
Lawrenson, Kate, Mhawech-Fauceglia, Paulette, Worthington, Jenny, Spindler, Tassja J., O'Brien, Darragh, Lee, Janet M., Spain, Georgia, Sharifian, Maryam, Wang, Guisong, Darcy, Kathleen M., Pejovic, Tanja, Sowter, Heidi M., Timms, John F. and Gayther, Simon A. 2014. Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the Secretomes of three-dimensional genetic models of ovarian carcinogenesis. International Journal of Cancer. https://doi.org/10.1002/ijc.29197
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
Dafou, Dimitra, Grun, Barbara, Sinclair, Jonathan, Lawrenson, Kate, Benjamin, Elizabeth C., Hogdall, Estrid, Kruger-Kjaer, Susanne, Christensen, Lise, Sowter, Heidi M., Al-Attar, Ahmed, Edmondson, Richard, Darby, Stephen, Berchuck, Andrew, Laird, Peter W., Pearce, C. Leigh, Ramus, Susan J., Jacobs, Ian J. and Gayther, Simon A. 2010. Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia (New York, N.Y.).
The Eag potassium channel as a new prognostic marker in ovarian cancer.
Asher, Viren, Khan, Raheela, Warren, Averil, Shaw, Robert, Schalkwyk, Gerhard V., Bali, Anish and Sowter, Heidi M. 2010. The Eag potassium channel as a new prognostic marker in ovarian cancer. Diagnostic pathology. https://doi.org/10.1186/1746-1596-5-78