Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes

Journal article


Al-Daghri, Nasser M., Abdi, Saba, Sabico, Shaun, Alnaami, Abdullah M., Wani, Kaiser A., Ansari, Mohammed G. A., Khattak, Malak Nawaz Khan, Khan, Nasiruddin, Tripathi, Gyanendra, Chrousos, George P. and McTernan, Philip G. 2021. Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes. biomolecules. 11 (11), p. 1693. https://doi.org/10.3390/biom11111693
AuthorsAl-Daghri, Nasser M., Abdi, Saba, Sabico, Shaun, Alnaami, Abdullah M., Wani, Kaiser A., Ansari, Mohammed G. A., Khattak, Malak Nawaz Khan, Khan, Nasiruddin, Tripathi, Gyanendra, Chrousos, George P. and McTernan, Philip G.
Abstract

Premature aging, as denoted by a reduced telomere length (TL), has been observed in several chronic inflammatory diseases, such as obesity and type 2 diabetes mellitus (T2DM). However, no study to date has addressed the potential inflammatory influence of the gut-derived Gram-negative bacterial fragments lipopolysaccharide, also referred to as endotoxin, and its influence on TL in low-grade inflammatory states such as type 2 diabetes mellitus (T2DM). The current study therefore investigated the influence of endotoxin and inflammatory factors on telomere length (TL) in adults with (T2DM: n = 387) and without (non-diabetic (ND) controls: n = 417) obesity and T2DM. Anthropometric characteristics were taken, and fasted blood samples were used to measure biomarkers, TL, and endotoxin. The findings from this study highlighted across all participants that circulating endotoxin (r = −0.17, p = 0.01) was inversely associated with TL, noting that endotoxin and triglycerides predicted 18% of the variance perceived in TL (p < 0.001). Further stratification of the participants according to T2DM status and sex highlighted that endotoxin significantly predicted 19% of the variance denoted in TL among male T2DM participants (p = 0.007), where TL was notably influenced. The influence on TL was not observed to be impacted by anti-T2DM medications, statins, or anti-hypertensive therapies. Taken together, these results show that TL attrition was inversely associated with circulating endotoxin levels independent of the presence of T2DM and other cardiometabolic factors, suggesting that low-grade chronic inflammation may trigger premature biological aging. The findings further highlight the clinical relevance of mitigating the levels of circulating endotoxin (e.g., manipulation of gut microbiome) not only for the prevention of chronic diseases but also to promote healthy aging.

KeywordsMolecular Biology; Biochemistry; premature aging
Year2021
Journalbiomolecules
Journal citation11 (11), p. 1693
PublisherMDPI AG
ISSN2218-273X
Digital Object Identifier (DOI)https://doi.org/10.3390/biom11111693
Web address (URL)http://hdl.handle.net/10545/626140
https://creativecommons.org/licenses/by/4.0/
hdl:10545/626140
Publication dates14 Nov 2021
Publication process dates
Deposited24 Nov 2021, 16:42
Accepted12 Nov 2021
ContributorsKing Saud University, Riyadh 11451, Saudi Arabia, A’Sharqiyah University, Ibra 400, Oman, University of Derby, National and Kapodistrian University of Athens, 11527 Athens, Greece and Nottingham Trent University
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https://repository.derby.ac.uk/item/9539x/gut-derived-endotoxin-and-telomere-length-attrition-in-adults-with-and-without-type-2-diabetes

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