Bacterial Interactions Affecting Chemotherapy Effectiveness

Journal article


Chambers, J.M and Illingworth, T. 2023. Bacterial Interactions Affecting Chemotherapy Effectiveness. McGill Science Undergraduate Research Journal. 18 (1), pp. 15 - 18. https://doi.org/10.26443/msurj.v18i1.190
AuthorsChambers, J.M and Illingworth, T.
Abstract

Chemotherapy resistance is a recurring challenge in cancer treatment, with specific bacteria impairing the effectiveness of certain chemotherapies. This study reviews three bacteria and their impact on chemotherapy drugs: Mycoplasma and gemcitabine, Fusobacterium nucleatum and oxaliplatin, bacterial β-glucuronase and irinotecan. Bacteria can have wide-ranging effects on cancer treatment; for instance, they may affect drug metabolism, alter toxin conversion, and encourage cancer growth. Whilst the presence of these bacteria was found to have a detrimental effect on the efficacy of chemotherapy treatment, we also consider wider interactions and interdependencies of the microbiota with drug treatments. Some cancer therapies depend on the delicate balance of the microbiome whilst simultaneously disrupting it by their very nature, particularly when antibiotics are introduced. Further research into the complex relationship between bacteria and the tumour micro-environment is needed. Treatments that focus on the immune-oncology microbiome axis or that explore genetic predisposition through the use of biomarkers could also support a more personalised approach.

KeywordsChemotherapy resistance; microbiotic interactions; cancer treatment
Year2023
JournalMcGill Science Undergraduate Research Journal
Journal citation18 (1), pp. 15 - 18
PublisherMSURJ
ISSN1718-0783
Digital Object Identifier (DOI)https://doi.org/10.26443/msurj.v18i1.190
Web address (URL)https://msurjonline.mcgill.ca/article/view/190
Accepted author manuscript
File Access Level
Open
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online22 Mar 2023
Publication process dates
Accepted21 Mar 2023
Deposited27 Mar 2023
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https://repository.derby.ac.uk/item/9xwq6/bacterial-interactions-affecting-chemotherapy-effectiveness

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Chambers & Illingworth 2023.pdf
File access level: Open


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Chambers & Illingworth 2023.pdf
License: CC BY 4.0
File access level: Open

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