Bacterial Interactions Affecting Chemotherapy Effectiveness
Journal article
Authors | Chambers, J.M and Illingworth, T. |
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Abstract | Chemotherapy resistance is a recurring challenge in cancer treatment, with specific bacteria impairing the effectiveness of certain chemotherapies. This study reviews three bacteria and their impact on chemotherapy drugs: Mycoplasma and gemcitabine, Fusobacterium nucleatum and oxaliplatin, bacterial β-glucuronase and irinotecan. Bacteria can have wide-ranging effects on cancer treatment; for instance, they may affect drug metabolism, alter toxin conversion, and encourage cancer growth. Whilst the presence of these bacteria was found to have a detrimental effect on the efficacy of chemotherapy treatment, we also consider wider interactions and interdependencies of the microbiota with drug treatments. Some cancer therapies depend on the delicate balance of the microbiome whilst simultaneously disrupting it by their very nature, particularly when antibiotics are introduced. Further research into the complex relationship between bacteria and the tumour micro-environment is needed. Treatments that focus on the immune-oncology microbiome axis or that explore genetic predisposition through the use of biomarkers could also support a more personalised approach. |
Keywords | Chemotherapy resistance; microbiotic interactions; cancer treatment |
Year | 2023 |
Journal | McGill Science Undergraduate Research Journal |
Journal citation | 18 (1), pp. 15 - 18 |
Publisher | MSURJ |
ISSN | 1718-0783 |
Digital Object Identifier (DOI) | https://doi.org/10.26443/msurj.v18i1.190 |
Web address (URL) | https://msurjonline.mcgill.ca/article/view/190 |
Accepted author manuscript | File Access Level Open |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 22 Mar 2023 |
Publication process dates | |
Accepted | 21 Mar 2023 |
Deposited | 27 Mar 2023 |
https://repository.derby.ac.uk/item/9xwq6/bacterial-interactions-affecting-chemotherapy-effectiveness
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Accepted author manuscript
Chambers & Illingworth 2023.pdf | ||
File access level: Open |
Publisher's version
Chambers & Illingworth 2023.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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