Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews

Journal article


Safari, Reza, Van der Linden, Marietta L. and Mercer, Tom H. 2017. Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews. Neurodegenerative Disease Management. https://doi.org/10.2217/nmt-2017-0009
AuthorsSafari, Reza, Van der Linden, Marietta L. and Mercer, Tom H.
Abstract

Although exercise training has been advocated as a nonpharmacological treatment for multiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To address this, we collated meta-analytic reviews that explored the effectiveness of exercise training for the treatment of MS-related fatigue. We searched five online databases for relevant reviews, published since 2005, and identified 172 records. Five reviews were retained for systematic extraction of information and evidence quality analysis. Although our review synthesis indicated that exercise training interventions have a moderate effect on fatigue reduction in people with MS, no clear insight was obtained regarding the relative effectiveness of specific types or modes of exercise intervention. Moreover, Grading of Recommendation Assessment, Development and Evaluation revealed that the overall quality of evidence emanating from these five reviews was ‘very low’.

KeywordsExercise; Multiple Sclerosis; Fatigue; Review
Year2017
JournalNeurodegenerative Disease Management
PublisherFuture Medicine
ISSN17582024
17582032
Digital Object Identifier (DOI)https://doi.org/10.2217/nmt-2017-0009
Web address (URL)http://hdl.handle.net/10545/621770
hdl:10545/621770
Publication dates20 Jun 2017
Publication process dates
Deposited27 Jul 2017, 12:41
Accepted24 Apr 2017
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Archived with thanks to Neurodegenerative Disease Management

ContributorsUniversity of Derby, Queen Margaret University, Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK, Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK and Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK
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