Advanced downstream purification of high value biopharmaceuticals

Conference poster


Yadav, VK 2022. Advanced downstream purification of high value biopharmaceuticals. HVB/BBNet ECR Workshop.
AuthorsYadav, VK
TypeConference poster
Abstract

Therapeutic proteins (antibodies, vaccines) have become one of the largest and fastest growing biopharmaceutics in the last two decades. The rapidly expanding market presents a great challenge to industrial manufacturing​. One of the most limiting factor in biopharmaceutical manufacturing is downstream product recovery due to the high-cost and insufficient capacities. The downstream process comprises different chromatographic, virus inactivation and filtration steps to achieve the quality constraints for protein therapeutics. To achieve efficient production at reduced costs, advanced simple alternative strategies are needed ​

KeywordsNanocrystals; Protein engineering; Biopharmaceuticals; drug delivery
Year2022
ConferenceHVB/BBNet ECR Workshop
Web address (URL)https://www.bbnet-nibb.co.uk/2022/07/08/bbnet-and-hvb-ecr-workshop-an-early-career-researcher-toolkit-for-the-bioeconomy/
Publication process dates
Deposited16 Dec 2022
Permalink -

https://repository.derby.ac.uk/item/9vqy6/advanced-downstream-purification-of-high-value-biopharmaceuticals

  • 16
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Elucidation of Short linear motif based interactions and dynamics of the ezrin, radixin, moesin and merlin FERM domains
Muhammad Ali, Alisa Khramushin, Yadav, V., Ora Schueler-Furman and Ylva Ivarsson 2023. Elucidation of Short linear motif based interactions and dynamics of the ezrin, radixin, moesin and merlin FERM domains. Biochemistry. Vol 62 (Issue 11), p. 1594–1607. https://doi.org/10.1021/acs.biochem.3c00096
Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
Ali, M., Khramushin, A., Yadav, V.K., Schueler-Furman, O. and Ivarsson, Y. 2023. Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin. Biochemistry. pp. 1-14. https://doi.org/10.1021/acs.biochem.3c00096
Polypeptides that interact with peptide tags at loops or termini and uses thereof
Yadav, V. 2022. Polypeptides that interact with peptide tags at loops or termini and uses thereof. WO2022214795A1
Positive and negative effects of graphite flake and monolayer graphene oxide templates on protein crystallization
Lin, Z., Tian, W., Yadav, V. K. and Yang, H. 2022. Positive and negative effects of graphite flake and monolayer graphene oxide templates on protein crystallization. Particuology. pp. 1-8. https://doi.org/10.1016/j.partic.2022.10.014
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
Li, Y., Balakrishnan, Vijaya Kumar . K., Rowse, M., Wu, C, G., Bravos, A. P., Yadav, VK, Ivarsson, Y., Strack, S., Novikova, I. V. and Xing, Y. 2022. Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition. Elife. 11, pp. 1-26. https://doi.org/10.7554/eLife.79736
DogCatcher allows loop-friendly protein-protein ligation
Heeble, A. H., Yadav, VK, Ferla, M. P., Bauer, C. C., Chuntharpursat-Bon, C., Huang, J., Bon, R. S. and Howarth, M. 2022. DogCatcher allows loop-friendly protein-protein ligation. Cell Chemical Biology. 29 (2), p. 339–350. https://doi.org/10.1016/j.chembiol.2021.07.005
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.
Yadav, V. 2020. Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. Molecular cell. Vol 79 (Issue 2), pp. 342-358. https://doi.org/10.1016/j.molcel.2020.06.029
Synthetic toolbox adapted from bacterial superglues to staple proteins in modular assemblies
Yadav, V. 2019. Synthetic toolbox adapted from bacterial superglues to staple proteins in modular assemblies. Protein Engineering II: from new new molecules to new processes. York, UK 15 - 17 Jul 2019 Fluidic Analytics.
Orthogonal toolbox of bacterial superglues for covalent interactions
Yadav, V. 2019. Orthogonal toolbox of bacterial superglues for covalent interactions. Synthetic Biology UK 2019. University of Warwick 09 - 10 Dec 2019 Biochemical society.
PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.
Yadav, V. 2017. PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis. Cell discovery. Vol 3 (2017, Article: 17027). https://doi.org/10.1038/celldisc.2017.27
Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome.
Yadav, V. 2016. Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome. The FEBS journal. Vol 284 (Issue 3), pp. 485-498. https://doi.org/10.1111/febs.13995
Systematic discovery of Short Linear Motifs decodes hippo pathway signalling
Yadav, V. 2016. Systematic discovery of Short Linear Motifs decodes hippo pathway signalling. The modularity of signalling proteins and networks, EMBO workshop. Seefeld in Tirol, Austria 20 - 25 Sep 2016 EMBO Workshop.
Structural and binding studies of SAP-1 protein with heparin.
Yadav, V. 2014. Structural and binding studies of SAP-1 protein with heparin. Chemical biology & drug design. Vol 85 (Issue 3), pp. 404 - 410. https://doi.org/10.1111/cbdd.12420