Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial

Journal article


Ashton, Ruth E, Aning, Jonathan J, Tew, Garry A, Robson, Wendy A and Saxton, John M 2021. Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial. Supportive care in cancer. 29, p. 4595–4605. https://doi.org/10.1007/s00520-021-06002-5
AuthorsAshton, Ruth E, Aning, Jonathan J, Tew, Garry A, Robson, Wendy A and Saxton, John M
Abstract

To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP). This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Participants performed 3 sets of 12–15 repetitions for each exercise, targeting each major muscle group. The control group received usual care only. Brachial artery flow-mediated dilatation (FMD) was the primary outcome and assessed at baseline, 3 and 6 months. Secondary outcomes included body weight, body fat, aerobic fitness, strength and blood-borne biomarkers associated with cardiometabolic risk. There was no significant difference between the groups in FMD at 3 or 6 months. However, there were improvements in aerobic exercise capacity (P < 0.01) and upper- (P < 0.01) and lower-limb (P = 0.01) strength in favour of the RET group at 6 months, accompanied by greater weight loss (P = 0.04) and a reduction in body fat (P = 0.02). Improvements in HRQoL were evident in the RET group at 3 and 6 months via the PCa-specific component of the FACT-P questionnaire (both P < 0.01). Five adverse events and one serious adverse event were reported throughout the trial duration. This study demonstrates that home-based RET is an effective and safe mode of exercise that elicits beneficial effects on aerobic exercise capacity, muscular strength and HR-QoL in men who have undergone RARP.

KeywordsCardiometabolic; Prostate cancer; Resistance exercise; Robot-assisted radical prostatectomy
Year2021
JournalSupportive care in cancer
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Journal citation29, p. 4595–4605
PublisherSpringer
ISSN1433-7339
Digital Object Identifier (DOI)https://doi.org/10.1007/s00520-021-06002-5
Web address (URL)https://link.springer.com/article/10.1007/s00520-021-06002-5
hdl:10545/625578
Output statusPublished
Publication dates23 Jan 2021
Publication process dates
Deposited01 Feb 2021
Accepted13 Jan 2021
Place of publicationGermany
ContributorsUniversity of Derby, Bristol Urological Institute, North Bristol NHS Trust, Southmead Hospital, Bristol, University of Northumbria and Freeman Hospital, Newcastle-upon-Tyne
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