Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial
Journal article
Authors | Ashton, Ruth E, Aning, Jonathan J, Tew, Garry A, Robson, Wendy A and Saxton, John M |
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Abstract | To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP). This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Participants performed 3 sets of 12–15 repetitions for each exercise, targeting each major muscle group. The control group received usual care only. Brachial artery flow-mediated dilatation (FMD) was the primary outcome and assessed at baseline, 3 and 6 months. Secondary outcomes included body weight, body fat, aerobic fitness, strength and blood-borne biomarkers associated with cardiometabolic risk. There was no significant difference between the groups in FMD at 3 or 6 months. However, there were improvements in aerobic exercise capacity (P < 0.01) and upper- (P < 0.01) and lower-limb (P = 0.01) strength in favour of the RET group at 6 months, accompanied by greater weight loss (P = 0.04) and a reduction in body fat (P = 0.02). Improvements in HRQoL were evident in the RET group at 3 and 6 months via the PCa-specific component of the FACT-P questionnaire (both P < 0.01). Five adverse events and one serious adverse event were reported throughout the trial duration. This study demonstrates that home-based RET is an effective and safe mode of exercise that elicits beneficial effects on aerobic exercise capacity, muscular strength and HR-QoL in men who have undergone RARP. |
Keywords | Cardiometabolic; Prostate cancer; Resistance exercise; Robot-assisted radical prostatectomy |
Year | 2021 |
Journal | Supportive care in cancer |
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer | |
Journal citation | 29, p. 4595–4605 |
Publisher | Springer |
ISSN | 1433-7339 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00520-021-06002-5 |
Web address (URL) | https://link.springer.com/article/10.1007/s00520-021-06002-5 |
http://hdl.handle.net/10545/625578 | |
hdl:10545/625578 | |
Output status | Published |
Publication dates | 23 Jan 2021 |
Publication process dates | |
Deposited | 01 Feb 2021 |
Accepted | 13 Jan 2021 |
Place of publication | Germany |
Contributors | University of Derby, Bristol Urological Institute, North Bristol NHS Trust, Southmead Hospital, Bristol, University of Northumbria and Freeman Hospital, Newcastle-upon-Tyne |
File | File Access Level Open |
https://repository.derby.ac.uk/item/9282q/supported-progressive-resistance-exercise-training-to-counter-the-adverse-side-effects-of-robot-assisted-radical-prostatectomy-a-randomised-controlled-trial
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