Kinetic modelling of synaptic functions in the alpha rhythm neural mass model
Journal article
Basabdatta, Sen Bhattacharya, Coyle, Damien H, Maguire, Liam P and Stewart, Jill 2012. Kinetic modelling of synaptic functions in the alpha rhythm neural mass model. Proceedings of the 22nd international conference on Artificial Neural Networks and Machine Learning - Volume Part I.
| Authors | Basabdatta, Sen Bhattacharya, Coyle, Damien H, Maguire, Liam P and Stewart, Jill |
|---|---|
| Abstract | In this work, we introduce the kinetic framework for modelling synaptic transmission in an existing neural mass model of the thalamocortical circuitry to study Electroencephalogram (EEG) slowing within the alpha frequency band (8–13 Hz), a hallmark of Alzheimer’s disease (AD). Ligand-gated excitatory and inhibitory synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and GABAA (gamma-amino-butyric acid) receptors respectively are modelled. Our results show that the concentration of the GABA neurotransmitter acts as a bifurcation parameter, causing the model to switch from a limit cycle mode to a steady state. Further, the retino-geniculate pathway connectivity plays a significant role in modulating the power within the alpha band, thus conforming to research proposing ocular biomarkers in AD. Overall, kinetic modelling of synaptic transmission in neural mass models has enabled a more detailed investigation into the neural correlates underlying abnormal EEG in AD. |
| Keywords | Kinetic Modelling, Alzheimer, synaptic transmission. neural mass models |
| Year | 2012 |
| Journal | Proceedings of the 22nd international conference on Artificial Neural Networks and Machine Learning - Volume Part I |
| Publisher | Springer-Verlag Berlin Heidelberg |
| Web address (URL) | http://hdl.handle.net/10545/623620 |
| http://creativecommons.org/licenses/by-nd/3.0/us/ | |
| hdl:10545/623620 | |
| Publication dates | 2012 |
| Publication process dates | |
| Deposited | 19 Mar 2019, 13:49 |
| Accepted | 2012 |
| ISBN | 978-3-642-33269-2 |
| Rights | Attribution-NoDerivs 3.0 United States |
| Contributors | University of Lincoln |
| File | File Access Level Open |
| File | File Access Level Open |
Permalink -
https://repository.derby.ac.uk/item/94y6q/kinetic-modelling-of-synaptic-functions-in-the-alpha-rhythm-neural-mass-model
Download files
43
total views0
total downloads0
views this month0
downloads this month
Export as
Related outputs
Application of the Lomb-Scargle Periodogram to Investigate Heart Rate Variability during Haemodialysis
Stewart, Jill, Stewart, Paul, Walker, Tom, Gullapudi, Latha, Eldehni, Mohamed T, Selby, Nicholas M and Taal, Maarten W 2020. Application of the Lomb-Scargle Periodogram to Investigate Heart Rate Variability during Haemodialysis. Journal of healthcare engineering. 2020, p. 8862074. https://doi.org/10.1155/2020/8862074An Analysis of Frequency of Continuous Blood Pressure Variation and Haemodynamic Responses during Haemodialysis.
Latha Gullapudi, Venkata R, White, Kelly, Stewart, Jill, Stewart, Paul, Eldehni, Mohammed T, Taal, Maarten W and Selby, Nicholas M 2021. An Analysis of Frequency of Continuous Blood Pressure Variation and Haemodynamic Responses during Haemodialysis. Blood purification. 51 (5). https://doi.org/10.1159/000516935Noninvasive continuous intradialytic blood pressure monitoring: the key to improving haemodynamic stability
Stewart, Paul and Stewart, Jill 2021. Noninvasive continuous intradialytic blood pressure monitoring: the key to improving haemodynamic stability. Current Opinion in Nephrology & Hypertension. 30 (6), pp. 559-562. https://doi.org/10.1097/MNH.0000000000000738An iterative run-to-run learning model to derive continuous brachial pressure estimates from arterial and venous lines during dialysis treatment
Stewart, Jill, Stewart, Paul, Walker, Tom, Viramontes-Hörner, Daniela, Lucas, Bethany, White, Kelly, Taal, Maarten W., Selby, Nicholas M. and Morris, Mel 2020. An iterative run-to-run learning model to derive continuous brachial pressure estimates from arterial and venous lines during dialysis treatment. Biomedical Signal Processing and Control. 65, p. 102346. https://doi.org/10.1016/j.bspc.2020.102346A feasibility study of non-invasive continuous estimation of brachial pressure derived from arterial and venous lines during dialysis
Stewart, Jill, Walker, Thomas, Eldehini, Tarek, Horner, Daniela Viramontes, Lucas, Bethany, White, Kelly, Muggleton, Andy, Selby, Nicholas M, Taal, Martin W and Stewart, Paul 2020. A feasibility study of non-invasive continuous estimation of brachial pressure derived from arterial and venous lines during dialysis. IEEE Journal of Translational Engineering in Health and Medicine. https://doi.org/10.1109/JTEHM.2020.3035988A new propelled wing aircraft configuration
Trancossi, Michele, Stewart, Jill and Pascoa, Jose C. 2016. A new propelled wing aircraft configuration. IMechE. https://doi.org/10.1115/IMECE2016-65373Modeling emergent patterns of dynamic desert ecosystems
Stewart, Jill, Parsons, A. J., Wainwright, J., Okin, G. S., Bestelmeyer, B. T., Fredrickson, E. L. and Schlesinger, W. H. 2014. Modeling emergent patterns of dynamic desert ecosystems. Ecological Monographs. 84 (3), pp. 373-410. https://doi.org/10.1890/12-1253.1Theoretical investigation into balancing high-speed flexible shafts, by the use of a novel compensating balancing sleeve
Knowles, Grahame, Kirk, Antony, Stewart, Jill, Bickerton, Ron and Bingham, Chris 2013. Theoretical investigation into balancing high-speed flexible shafts, by the use of a novel compensating balancing sleeve. Proc IMechE Part C: J Mechanical Engineering Science. 228 (13), pp. 2323-2336. https://doi.org/10.1177/0954406213517376Multi-objective evolutionary—fuzzy augmented flight control for an F16 aircraft
Stewart, P, Gladwin, D, Parr, M and Stewart, Jill 2009. Multi-objective evolutionary—fuzzy augmented flight control for an F16 aircraft. Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering. 224 (3), pp. 293-309. https://doi.org/10.1243/09544100JAERO610Improved decision support for engine-in-the-loop experimental design optimization.
Gladwin, D, Stewart, P, Stewart, Jill, Chen, R and Winward, E 2009. Improved decision support for engine-in-the-loop experimental design optimization. Journal of Automobile Engineering.. 224 (2), pp. 201-218. https://doi.org/10.1243/09544070JAUTO1213Mathematical model of a constructional coanda effect nozzle.
Trancossi, Michele, Stewart, Jill, Subhash, M and Angeli, Diego 2016. Mathematical model of a constructional coanda effect nozzle. Journal of Applied Fluid Mechanics..Constructal design of an entropic wall With circulating water inside.
Trancossi, Michele, Stewart, Jill, Dumas, Antonio, Madonia, Mauro and Marques, Jose Pascoa 2016. Constructal design of an entropic wall With circulating water inside. Journal of Heat Transfer. 138 (8), p. 082801. https://doi.org/10.1115/1.4033346Increasing the impact of mathematics support on aiding student transition in higher education.
Gallimore, M. and Stewart, Jill 2014. Increasing the impact of mathematics support on aiding student transition in higher education. Teaching Mathematics and Its Applications: International Journal of the IMA. 33 (2), pp. 98-109. https://doi.org/10.1093/teamat/hru008Integrated flight/thrust vectoring control for jet-powered unmanned aerial vehicles with ACHEON propulsion.
Cen, Zhaohui, Smith, Tim, Stewart, Paul and Stewart, Jill 2014. Integrated flight/thrust vectoring control for jet-powered unmanned aerial vehicles with ACHEON propulsion. Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering. 229 (6), pp. 1057-1075. https://doi.org/10.1177/0954410014544179Experimental and numerical investigation of fuel–air mixing in a radial swirler slot of a dry low emission gas turbine combustor.
Agbonzikilo, Festus Eghe, Owen, Ieuan, Stewart, Jill, Sadasivuni, Suresh Kumar, Riley, Mike and Sanderson, Victoria 2015. Experimental and numerical investigation of fuel–air mixing in a radial swirler slot of a dry low emission gas turbine combustor. Journal of Engineering for Gas Turbines and Power. 138 (6), p. 061502. https://doi.org/10.1115/1.4031735Generator voltage stabilisation for series-hybrid electric vehicles.
Stewart, P., Gladwin, D., Stewart, Jill and Cowley, R. 2008. Generator voltage stabilisation for series-hybrid electric vehicles. ISA Transactions. 47 (2), pp. 222-228. https://doi.org/10.1016/j.isatra.2007.12.004Internal combustion engine control for series hybrid electric vehicles by parallel and distributed genetic programming/multiobjective genetic algorithms
Gladwin, Daniel, Stewart, Paul and Stewart, Jill 2010. Internal combustion engine control for series hybrid electric vehicles by parallel and distributed genetic programming/multiobjective genetic algorithms. International Journal of Systems Science. https://doi.org/10.1080/00207720903144479A novel genetic programming approach to the design of engine control systems for the voltage stabilization of hybrid electric vehicle generator outputs
Gladwin, Daniel, Stewart, Paul and Stewart, Jill 2011. A novel genetic programming approach to the design of engine control systems for the voltage stabilization of hybrid electric vehicle generator outputs. Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. https://doi.org/10.1177/0954407011407414A controlled migration genetic algorithm operator for hardware-in-the-loop experimentation
Gladwin, Daniel, Stewart, Paul and Stewart, Jill 2011. A controlled migration genetic algorithm operator for hardware-in-the-loop experimentation. Engineering Applications of Artificial Intelligence. https://doi.org/10.1016/j.engappai.2011.01.006Real-time thermal management of permanent magnet synchronous motors by resistance estimation
Wilson, S. D., Stewart, Paul and Stewart, Jill 2012. Real-time thermal management of permanent magnet synchronous motors by resistance estimation. IET Electric Power Applications. https://doi.org/10.1049/iet-epa.2010.0232