The fractal viewpoint of tumors and nanoparticles.
Journal article
Alexiou, A., Tsagkaris, C., Chatzichronis, S., Koulouris, A., Haranas, I., Gkigkitzis, I., Zouganelis, G., Mukerjee, N., Maitr, S., Jha, N. K., Batiha, G. and Amjad, M. 2022. The fractal viewpoint of tumors and nanoparticles. Current Medicinal Chemistry. 30 (3), pp. 356 - 370. https://doi.org/10.2174/0929867329666220801152347
| Authors | Alexiou, A., Tsagkaris, C., Chatzichronis, S., Koulouris, A., Haranas, I., Gkigkitzis, I., Zouganelis, G., Mukerjee, N., Maitr, S., Jha, N. K., Batiha, G. and Amjad, M. |
|---|---|
| Abstract | Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, limiting the side effects simultaneously. Since the first observation of the quantum tunneling phenomenon, many multidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry. |
| Keywords | Box-Counting Algorithm; Cancer; Chaos Theory; Drug Delivery; Fractal Dimension; Fractality; Imaging Data; Lacunarity; Nanoparticles; Pharmacokinetics; Quantum Tunneling; Scanning Tunneling Microscope; Succolarity |
| Year | 2022 |
| Journal | Current Medicinal Chemistry |
| Journal citation | 30 (3), pp. 356 - 370 |
| Publisher | Bentham Science |
| ISSN | 1875-533X |
| Digital Object Identifier (DOI) | https://doi.org/10.2174/0929867329666220801152347 |
| Web address (URL) | https://www.eurekaselect.com/article/125260 |
| Accepted author manuscript | License File Access Level Controlled |
| Output status | Published |
| Publication dates | |
| Online | 30 Sep 2022 |
| Publication process dates | |
| Deposited | 23 Nov 2022 |
Permalink -
https://repository.derby.ac.uk/item/993q7/the-fractal-viewpoint-of-tumors-and-nanoparticles
60
total views1
total downloads1
views this month0
downloads this month
Export as
Related outputs
In-silico Codon Context and Synonymous Usage Analysis of Genes for Molecular Mechanisms Inducing Autophagy and Apoptosis with Reference to Neurodegenerative Disorders.
Khandia, R., Gurjar, P., Romashchenko, V., Al-Hussain, S. A., Alexiou, A., Zouganelis G. and Zaki, M.E.A. 2024. In-silico Codon Context and Synonymous Usage Analysis of Genes for Molecular Mechanisms Inducing Autophagy and Apoptosis with Reference to Neurodegenerative Disorders. Journal of Alzheimer's disease : JAD. 99 (3), pp. 927-939. https://doi.org/10.3233/jad-240158Compositional constraints and selection forces dictate codon usage in human bocavirus
Khandia, R.,, Singhal, S., Kumar, U., Shende, K., Pandey, M.K., Povetkin, S.N., Rzhepakovsky, I.V., Raut, A., Alexiou, A., Dhama, K., Zouganelis, G. and Khan. A. A. 2023. Compositional constraints and selection forces dictate codon usage in human bocavirus. Journal of King Saud University - Science. 35 (6), pp. 1-11. https://doi.org/10.1016/j.jksus.2023.102726Low Throughput Direct Cycle Sequencing of Polymerase Chain Reaction (PCR) Products
Nikolaos Tairis and Zouganelis, G. 2023. Low Throughput Direct Cycle Sequencing of Polymerase Chain Reaction (PCR) Products. in: Scarlett, Gary (ed.) DNA Manipulation and Analysis New York, NY Springer. pp. 195–211The Efficient Activity of Glabridin and its Derivatives Against EGFR-mediated Inhibition of Breast Cancer
Marios Papadakis, Arabinda Ghosh, Debanjana Ghosh, Nobendu Mukerjee, Swastika Maitra, Padmashree Das, Abhijit Dey, Souty M.Z. Sharkawi, Georgios D. Zouganelis, Athanasios Alexiou, Somdatta Yashwant Chaudhari, Ritika Sharma, Sonali Arun Waghmare, Gaber El-saber Batiha and Zouganelis, G. 2023. The Efficient Activity of Glabridin and its Derivatives Against EGFR-mediated Inhibition of Breast Cancer. Current Medicinal Chemistry. https://doi.org/10.2174/0929867330666230303120942Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats
Salihu, M., Batiha, G.E.S., Kasozi, K.I., Zouganelis, G., Sharkawi, S.M., Ahmed, E.I., Usman, I.M., Nalugo, H., Ochieng, J.J., Ssengendo, I., Okeniran, O.S., Pius, T., Kimanje, K. R., Kegoye, E.S., Kenganzi, R. and Ssempijjai, F. 2022. Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats. Toxicology Reports. 9, pp. 699-712. https://doi.org/10.1016/j.toxrep.2022.03.026Development and validation of anti-human Alpha synuclein DNA aptamer using computer modelling techniques—an in silico study
Rock, M., Zouganelis, G., Belchior de Andrade, A., Drake, S., Alexiou, A., Albrakati, A., Bathia, G. E. S. and Illingworth, T. 2022. Development and validation of anti-human Alpha synuclein DNA aptamer using computer modelling techniques—an in silico study. Journal of Integrative Neuroscience. 21 (1), p. 5. https://doi.org/10.31083/j.jin2101005Characterization and phylogeny of fungi isolated from industrial wastewater using multiple genes
Ezeonuegbu, B.A., Abdullahi, M.D., Whong, C.M., Sohunago, J.W., Kassem, H.S., Yaro, C.A., Hetta, H.F., Mostafa-Hedeab, G., Zouganelis, G. and Batiha, G.E.S 2022. Characterization and phylogeny of fungi isolated from industrial wastewater using multiple genes. Scientific Reports. 12, pp. 1-11. https://doi.org/10.1038/s41598-022-05820-9Photoperiod-Dependent Expression of MicroRNA in Drosophila.
Pegoraro, M., Fishman, B., Zonato, V., Zouganelis, G., Francis, A., Kyriacou, C. P. and Tauber, E. 2022. Photoperiod-Dependent Expression of MicroRNA in Drosophila. International Journal of Molecular Sciences. 23 (9), pp. 1-14. https://doi.org/10.3390/ijms23094935The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels
Islam, Yamir, Ehtezazi, Parinaz, Cashmore, Andrew, Marinsalda, Elena, Leach, Andrew G., Coxon, Christopher R., Fatokun, Amos A., Sexton, Darren W., Khan, Iftikhar, Downing, James, Pluchino, Stefano, Sivakumaran, Muttuswamy, Teixido, Meritxell, Ehtezazi, Touraj and Zouganelis, George 2020. The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels. Journal of Pharmaceutical Science. https://doi.org/10.1016/j.xphs.2020.12.004