Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions

Journal article


Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456
AuthorsSreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh
Abstract

The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same “nano” specific physicochemical properties, which make these materials attractive, may also contribute to hazards for individuals exposed to these materials. In 2021, it was estimated that 7 out of 10 deaths globally were accredited to chronic diseases, such as chronic liver disease, asthma, and cardiovascular-related illnesses. Crucially, it is also understood that a significant proportion of global populace numbering in the billions are currently living with a range of chronic undiagnosed health conditions. Due to the significant number of individuals affected, it is important that people suffering from chronic disease also be considered and incorporated in NM hazard assessment strategies. This review examined and analyzed the literature that focused on NM-induced adverse health effects in models which are representative of individuals exhibiting pre-existing medical conditions with focus on the pulmonary, cardiovascular, hepatic, gastrointestinal, and central nervous systems. The overall objective of this review was to outline available data, highlighting the important role of pre-existing disease in NM-induced toxicity with the aim of establishing a weight of evidence approach to inform the public on the potential hazards posed by NMs in both healthy and compromised persons in general population.

Keywordsengineered nanomaterials ; pre-existing disease; toxicity ; inflammation
Year2022
JournalJournal of Toxicology and Environmental Health, Part B: Critical Reviews
Journal citationpp. 1-27
PublisherRoutledge, Taylor and Francis Group
ISSN 1521-6950
Digital Object Identifier (DOI)https://doi.org/10.1080/10937404.2022.2153456
Web address (URL)https://www.tandfonline.com/doi/full/10.1080/10937404.2022.2153456
Output statusPublished
Publication dates06 Dec 2022
Publication process dates
Deposited11 Jan 2023
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