Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions

Journal article


Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456
AuthorsSreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh
Abstract

The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same “nano” specific physicochemical properties, which make these materials attractive, may also contribute to hazards for individuals exposed to these materials. In 2021, it was estimated that 7 out of 10 deaths globally were accredited to chronic diseases, such as chronic liver disease, asthma, and cardiovascular-related illnesses. Crucially, it is also understood that a significant proportion of global populace numbering in the billions are currently living with a range of chronic undiagnosed health conditions. Due to the significant number of individuals affected, it is important that people suffering from chronic disease also be considered and incorporated in NM hazard assessment strategies. This review examined and analyzed the literature that focused on NM-induced adverse health effects in models which are representative of individuals exhibiting pre-existing medical conditions with focus on the pulmonary, cardiovascular, hepatic, gastrointestinal, and central nervous systems. The overall objective of this review was to outline available data, highlighting the important role of pre-existing disease in NM-induced toxicity with the aim of establishing a weight of evidence approach to inform the public on the potential hazards posed by NMs in both healthy and compromised persons in general population.

Keywordsengineered nanomaterials ; pre-existing disease; toxicity ; inflammation
Year2022
JournalJournal of Toxicology and Environmental Health, Part B: Critical Reviews
Journal citationpp. 1-27
PublisherRoutledge, Taylor and Francis Group
ISSN 1521-6950
Digital Object Identifier (DOI)https://doi.org/10.1080/10937404.2022.2153456
Web address (URL)https://www.tandfonline.com/doi/full/10.1080/10937404.2022.2153456
Output statusPublished
Publication dates06 Dec 2022
Publication process dates
Deposited11 Jan 2023
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Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15–19 in lung cancer
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Field cancerisation in colorectal cancer: A new frontier or pastures past?
Patel, A, Tripathi, G, Gopalakrishnan, K, Williams, N and Arasaradnam, R.P 2015. Field cancerisation in colorectal cancer: A new frontier or pastures past? World Journal of Gastroenterology. https://doi.org/10.3748/wjg.v21.i13.3763
Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells
Murphy, A, Jackisch, L., Azharian, S, Aladel, A, Barker, G, Tripathi, G, Chappell, M and McTernan, P 2014. Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells. bioscientifica. https://doi.org/10.1530/endoabs.44.P191
Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss
Kumsaiyai, W, Al-Daghri, N, Kyrou, I, Vrbikova, J, Hainer, V, Fried, M, Sramkova, P, Barber, T, S Kumar, Tripathi, G and McTernan, P 2014. Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss. bioscientifica. https://doi.org/10.1530/endoabs.34.P238
Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes
Jackisch, L, Murphy, A, Al-Daghri, N, McTernan, P, Randeva, H and Tripathi, G 2014. Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes. bioscientifica. https://doi.org/10.1530/endoabs.44.P193
Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3
Adaikalakoteswari, A, Finer, S, Voyias, P.D, McCarthy, M, Vatish, M, Moore, J, Smart-Halajko, M, Bawazeer, N, Al-Daghri, N.M, McTernan, P.G, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3. American Diabetes Association.
Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks
Finer, S, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks. Norwich Research ParK.
The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes
Piya, Milan K, Harte, A. L, Sivakumar, K, Tripathi, G, Voyias, P. D, James, S, Sabico, S, Al-Daghri, N, M, Saravanan, P, Barber, T. M, Kumar, S, Vatish, M and McTernan, P. G 2014. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. American Journal of Physiology Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00308.2013
Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.
Adaikalakoteswari, A, Jayashri, R, Sukumar, N, Venkataraman, H, Pradeepa, R, Gokulakrishnan, K, Anjana, R.M, McTernan, P.G, Tripathi, G, Patel, V and Kumar, S. 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-014-0129-4
Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK
Adaikalakoteswari, A, Vatish, M, Lawson, A, Wood, C, Sivakumar, K, McTernan, P, Webster, C, Anderson, N, Yajnik, C, Tripathi, G and Saravanan, P 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients. https://doi.org/10.3390/nu7042401
Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly.
Reddy, N.L, Peng, C, Carreira, M.C, Halder, L, Hattersley, J, Piya, M.K, Tripathi, G, Randeva, H.S, Casanueva, F.F, McTernan, P.G and Kumar, S 2014. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Cinical Endocrinology. https://doi.org/10.1111/cen.12652
Maternal inheritance of circulating irisin in humans.
Al-Daghri, N.M, Al-Attas, O.S, Alokail, M.S, Alkharfy, K.M, Yousef, M, Vinodson, B, Amer, O.E, Alnaami, A.M, Sabico, S, Tripathi, G and Piya, M.K. 2014. Maternal inheritance of circulating irisin in humans. Clincal Science. https://doi.org/10.1042/CS20130426
Surface charge visualization at viable living cells
Perry, D, Paulose Nadappuram, B, Momotenko, D, Voyias, P.D, Page, A, Tripathi, G, Frenguelli, B.G and Unwin, P.R 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b13153
Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery.
de la Escalera, L.M, Kyrou, I, Vrbikova, J, Hainer, V, Sramkova, P, Fried, M, Piya, M.K, Kumar, S, Tripathi, G and McTernan, P.G 2017. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine. https://doi.org/10.1186/s12916-017-0797-5
Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation.
Reddy, N.L, Jones, T.A, Wayte, S.C, Adesanya, O, Sankar, S, Yeo, Y.C, Tripathi, G, McTernan, P.G, Randeva, H.S, Kumar, S and Hutchinson, C.E 2014. Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/jc.2013-2036
Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases.
Al-Disi, D, A-Daghri, N, Khan, N, Alfadda, A, Sallam, R, Alsaif, M, Sabico, S, Tripathi, G and McTernan, P 2015. Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases. Nutrients. https://doi.org/10.3390/nu7085290
Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes.
Hu, J, Kyrou, I, Tan, B.K, Dimitriadis, G.K, Ramanjaneya, M, Tripathi, G, Patel, V, James, S, Kawan, M, Chen, J and Randeva, H.S 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology. https://doi.org/10.1210/en.2015-1944
Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects
Al-Daghri, N.M, Rahman, S, Sabico, S, Yakout, S, Wani, K, Al-Attas, O.S, Saravanan, P, Tripathi, G, McTernan, P.G and Alokail, M.S 2016. Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients. https://doi.org/10.3390/nu8090460
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
Kermanizadeh, A., Brown, D. M., Moritz, W. and Stone, V. 2019. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. Scientific Reports. 9 (7295), pp. 1-9. https://doi.org/10.1038/s41598-019-43870-8
The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials
Ali Kermanizadeh, David M. Brown and Vicki Stone 2019. The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials. PLos ONE. Vol 14 (Issue 8). https://doi.org/10.1371/journal.pone.0220974
Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencatti, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas 2019. Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications. https://doi.org/10.1101/647347
Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone 2019. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and Fibre Toxicology. Vol 16 (Issue 1), p. Article: 42. https://doi.org/10.1186/s12989-019-0326-0
Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe
Ali, F., Aute, S., Sreedharan, S., Anila, H.A., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2018. Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe. Chemical Communications. 54 (15), pp. 1849-185. https://doi.org/10.1039/c7cc09433g
Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging
Sreedharan, S., Hoskere, A., Ali, F., Smythe, G.C., Thomas, J. A. and Das, A. 2018. Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging. Chemical Communications. 54 (30), pp. 3735-3738. https://doi.org/10.1039/c8cc01332b
Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties
Sinopoli, A., Sreedharan, S., Jarman, P.J., Robinson, D., Clemmet, C., Scattergood, P.A., Rice, C.R., Smythe, C.G., Thomas, J.A. and Elliott, P.I. 2018. Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties. Dalton Transactions. 47 (14), pp. 4931-4940. https://doi.org/10.1039/c8dt00046h
A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells
Singh, H., Sreedharan, S., Tiwari, R., Walther, C., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells. Crystal Growth & Design. 18 (11), pp. 7199-7206. https://doi.org/10.1021/acs.cgd.8b01409
Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging
Singh, H., Sreedharan, S., Tiwari, K., Green, N.H., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging. Chemical Communications. 55 (4), pp. 521-524. https://doi.org/10.1039/c8cc08610a
Mitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release
Pramanik, S.K., Sreedharan, S., Singh, H., Khan, M., Tiwari, K., Shiras, A., Smythe, C., Thomas, J.A. and Das, A. 2018. Mitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release. Bioconjugate Chemistry. 29 (11), pp. 3532-3543. https://doi.org/10.1021/acs.bioconjchem.8b00460
Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Løhr M, Kermanizadeh A, Loft S, Ebbehøj N, Hansen ÅM, Pedersen PB, Koponen IK, Nørskov EC, Møller P and Vogel U 2018. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. Vol 33 (Issue 1), pp. 105 - 115. https://doi.org/10.1093/mutage/gex021
Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Løhr M, Kermanizadeh A, Loft S, Ebbehøj NE, Hansen ÅM, Kalevi Koponen I, Nørskov EC and Møller P 2018. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environmental and molecular mutagenesis. Vol 59 (Issue 6), pp. 539-548. https://doi.org/10.1002/em.22193
Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.
Jantzen K, Jensen A, Kermanizadeh A, Elholm G, Sigsgaard T, Møller P, Roursgaard M and Loft S 2018. Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects. Toxicological sciences : an official journal of the Society of Toxicology. Vol 163 (Issue 2), p. 353–363. https://doi.org/10.1093/toxsci/kfy027
Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles.
Audureau É, Simon-Deckers A, Franco-Montoya ML, Annangi B, Kermanizadeh A, Boczkowski J and Lanone S 2018. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Scientific Reports. Vol 8 (Issue 1, Article: 8554). https://doi.org/10.1038/s41598-018-26988-z
Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles
Pramanik, S.K., Sreedharan, S., Singh, H., Green, N.H., Smythe, C., Thomas, J.A. and Das, A. 2017. Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles. Chemical Communications. 53 (94), pp. 12672-12675. https://doi.org/10.1039/c7cc08185e
Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria
Sreedharan, S., Gill, M.R., Garcia, E., Saeed, H.K., Robinson, D., Byrne, A., Cadby, A., Keyes, T.E., Smythe, C., Pellett, P. and Bernardino de la Serna, J. 2017. Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria. Journal of the American Chemical Society. 139 (4), pp. 15907-15913. https://doi.org/10.1021/jacs.7b08772
A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells
Ali, F., Sreedharan, S., Ashoka, A.H., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2017. A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells. Analytical Chemistry. 89 (22), pp. 12087-12093. https://doi.org/10.1021/acs.analchem.7b02567
Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice. Toxicological Sciences. Vol 158 (Issue 1), pp. 176 - 187. https://doi.org/10.1093/toxsci/kfx080
Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis
Kermanizadeh, A., Jantzen, K., Ward, M.B., Durhuus, J.A., Juel Rasmussen, L., Loft, S. and Møller, P. 2017. Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology. Vol 11 (Issue 2), pp. 184-200. https://doi.org/10.1080/17435390.2017.1279359
A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.
Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845
Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. Vol 3 (Issue 11, Article: e00458). https://doi.org/10.1016/j.heliyon.2017.e00458
Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials
Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35
Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies
Saeed, H.K., Jarman, P.J., Archer, S., Sreedharan, S., Saeed, I.Q., Mckenzie, L.K., Weinstein, J.A., Buurma, N.J., Smythe, C.G. and Thomas, J.A. 2017. Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies. Angewandte Chemie. 56 (41), pp. 12628-12633. https://doi.org/10.1002/ange.201707350
Nanotoxicology: Focus on nanomedicine
Johnston, H., Kermanizadeh, A. and Stone, V. Raj Bawa, Gerald F. Audette and Brian Reese (ed.) 2016. Nanotoxicology: Focus on nanomedicine. New York Routledge.
Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide
Christophersen, D.V., Jacobsen, N.R., Jensen, D.M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Voge, U., Wallin, H. and Møller, P. 2016. Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLos ONE. Vol 11 (Issue 8, Article: e0160731). https://doi.org/10.1371/journal.pone.0160731
Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles
Vranic, S., Gosens, I., Jacobsen, N.R., Jensen, K.A., Bokkers, B., Kermanizadeh, A., Stone, V., Baeza-Squiban, A., Cassee, F.R., Tran, L. and Boland, S. 2016. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Archives of toxicology. Vol 91 (Issue 1), pp. 353 - 363. https://doi.org/10.1007/s00204-016-1673-3
Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells
Kermanizadeh, A., Villadsen, K., Østrem, R.G., Jensen, K.J., Møller, P. and Loft, S. 2016. Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells. Basic and Clinical Pharmacology and Toxicology. Vol 120 (Issue 4), pp. 380 - 389. https://doi.org/10.1111/bcpt.12692
Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
Møller, P., Christophersen, D.V., Jacobsen, N.R., Skovmand, A., Gouveia, A.C.D., Andersen, M.H.G., Kermanizadeh, A., Jensen, D.M., Danielsen, P.H., Roursgaard, M., Jantzen, K. and Loft, S. 2016. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology. Vol 46 (Issue 5), pp. 437-476. https://doi.org/10.3109/10408444.2016.1149451
A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges
Kermanizadeh, A., Gosens, I., MacCalman, L., Johnston, H., Danielsen, P.H., Jacobsen, N.R., Lenz, A.-G., Fernandes, T., Schins, R.P.F., Cassee, F.R., Wallin, H., Kreyling, W., Stoeger, T., Loft, S., Møller, P., Tran, L. and Stone, V. 2016. A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health - Part B: Critical Reviews. Vol 19 (Issue 1), pp. 1-28. https://doi.org/10.1080/10937404.2015.1126210
An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine
Matthew S.P. Boyles, Leagh G. Powell, Ali Kermanizadeh, Helinor J. Johnston, Barbara Rothen-Rutishauser, Vicki Stone and Martin J.D. Clift 2016. An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. in: Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production Wiley Online Library. pp. 443-468
Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes.
Borghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P 2016. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes. Mutagenesis. Vol 32 (Issue 1), p. 173–180. https://doi.org/10.1093/mutage/gew036
Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents
Song, L., Guo, Y., Roebuck, D., Chen, C., Yang, M., Yang, Z., Sreedharan, S., Glover, C., Thomas, J.A., Liu, D. and Guo, S. Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents. ACS Applied Materials & Interfaces. 7 (33), pp. 18707-18716. https://doi.org/10.1021/acsami.5b05228
Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats
Løhr, M., Folkmann, J.K., Sheykhzade, M., Jensen, L.J., Kermanizadeh, A., Loft, S. and Møller, P. 2015. Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLos ONE. Vol 10 (Issue 3, Article: e0118773). https://doi.org/10.1371/journal.pone.0118773
Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review
Kermanizadeh, A., Balharry, D., Wallin, H., Loft, S. and Møller, P. 2015. Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review. Critical Reviews in Toxicology. Vol 45 (Issue 10), pp. 837-872. https://doi.org/10.3109/10408444.2015.1058747
Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories
Jacobsen, N.R., Stoeger, T., van den Brule, S., Saber, A.T., Beyerle, A., Vietti, G., Mortensen, A., Szarek, J., Budtz, H.C., Kermanizadeh, A., Banerjee, A., Ercal, N., Vogel, U., Wallin, H. and Møller, P. 2015. Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories. Food and Chemical Toxicology. Vol 85 (Nov 2015), pp. 84 - 95. https://doi.org/10.1016/j.fct.2015.08.008
Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice
Gosens, I., Kermanizadeh, A., Jacobsen, N.R., Lenz, A.-G., Bokkers, B., De Jong, W.H., Krystek, P., Tran, L., Stone, V., Wallin, H., Stoeger, T. and Cassee, F.R. 2015. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLos ONE. Vol 10 (Issue 5, Article: 0126934). https://doi.org/10.1371/journal.pone.0126934
The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation
Nattrass, C., Horwell, C.J., Damby, D.E., Kermanizadeh, A., Brown, D.M. and Stone, V. 2015. The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation. Journal of Occupational Medicine and Toxicology. Vol 10 (Issue 1, Article: 23). https://doi.org/10.1186/s12995-015-0064-7
Nanotoxicology
Dominique Balharry, Eva Gubbins, Helinor Johnston, Kermanizadeh, A. and Vicki Stone 2015. Nanotoxicology. in: Nanoparticles in the Lung Boca Raton CRC Press.
The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review
Kermanizadeh, A., Chauché, C., Brown, D.M., Loft, S. and Møller, P. 2014. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 111 - 124. https://doi.org/10.1002/em.21926
Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells
Cao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P. 2014. Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells. International Journal of Toxicology. Vol 34 (Issue 1), pp. 67 - 76. https://doi.org/10.1177/1091581814560032
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Belade, E., Chrusciel, S., Armand, L., Simon-Deckers, A., Bussy, C., Caramelle, P., Gagliolo, J.-M., Boyer, L., Lanone, S., Pairon, J.-C., Kermanizadeh, A. and Boczkowski, J. 2014. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. Vol 89 (Issue 9), pp. 1543 - 1556. https://doi.org/10.1007/s00204-014-1324-5
Role of oxidative stress in carbon nanotube-generated health effects
Møller, P., Christophersen, D.V., Jensen, D.M., Kermanizadeh, A., Roursgaard, M., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Role of oxidative stress in carbon nanotube-generated health effects. Archives of toxicology. Vol 88 (Issue 11), pp. 1939 - 1964. https://doi.org/10.1007/s00204-014-1356-x
Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals
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Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure
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Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
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The role of Kupffer cells in the hepatic response to silver nanoparticles.
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