Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients
Journal article
Authors | Al-Daghri, N.M, Mohammed, A.K, Al-Attas, O.S, Ansari, M.G.A, Wani, K, Hussain, S.D, Sabico, S, Tripathi, G and Alokail, M.S |
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Abstract | There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms (Taq-I, Bsm-I, Apa-I and Fok-I) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes. |
Year | 2017 |
Journal | Scientific Reports |
Publisher | Nature |
ISSN | 20452322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-017-08621-7 |
Web address (URL) | http://hdl.handle.net/10545/624105 |
hdl:10545/624105 | |
Publication dates | 15 Aug 2017 |
Publication process dates | |
Deposited | 09 Aug 2019, 08:51 |
Contributors | University of Westminster |
https://repository.derby.ac.uk/item/93y03/vitamin-d-receptor-gene-polymorphisms-modify-cardiometabolic-response-to-vitamin-d-supplementation-in-t2dm-patients
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