Drug induced liver injury - a 2023 update.

Journal article


Allison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A. 2023. Drug induced liver injury - a 2023 update. Journal of Toxicology and Environmental Health, Part B. 26 (8), pp. 1-26. https://doi.org/10.1080/10937404.2023.2261848
AuthorsAllison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A.
Abstract

Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocellular, cholestatic or mixed and might also involve immune responses. When DILI occurs in dose-dependent manner, it is referred to as intrinsic, while if the injury occurs spontaneously, it is termed as idiosyncratic. This review predominately focused on idiosyncratic liver injury. The established molecular mechanisms for DILI include (1) mitochondria dysfunction, (2) increased reactive oxygen species levels, (3) presence of elevated apoptosis and necrosis, (4) and bile duct injuries associated with immune mediated pathways. However, it should be emphasized that the underlying mechanisms responsible for DILI are still unknown. Prevention strategies are critical as incidences occur frequently, and treatment options are limited once the injury has developed. The aim of this review was to utilize retrospective cohort studies from across the globe to gain insight into epidemiological patterns. This review considers (1) what is currently known regarding the mechanisms underlying DILI, (2) discusses potential risk factors and (3) implications of the coronavirus pandemic on DILI presentation and research. Future perspectives are also considered and discussed and include potential new biomarkers, causality assessment and reporting methods.

KeywordsDrug-Induced Liver Injury (DILI); idiosyncratic DILI; biomarkers
Year2023
JournalJournal of Toxicology and Environmental Health, Part B
Journal citation26 (8), pp. 1-26
PublisherTaylor & Francis
ISSN1521-6950
Digital Object Identifier (DOI)https://doi.org/10.1080/10937404.2023.2261848
Web address (URL)https://www.tandfonline.com/doi/full/10.1080/10937404.2023.2261848
Output statusPublished
Publication dates
Online19 Oct 2023
Publication process dates
Deposited20 Oct 2023
Permalink -

https://repository.derby.ac.uk/item/q2500/drug-induced-liver-injury-a-2023-update

  • 23
    total views
  • 0
    total downloads
  • 4
    views this month
  • 0
    downloads this month

Export as

Related outputs

AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research
Yu, H., O'Neill, S. and Kermanizadeh, A. 2023. AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research. Bioengineering. 10 (10), pp. 1-18. https://doi.org/10.3390/bioengineering10101134
Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH.
Kermanizadeh, Ali, Valli, Jessica, Sanchez, Katarzyna, Hutter, Simon, Pawlowska, Agnieszka, Whyte, Graeme, Moritz, Wolfgang and Stone, Vicki 2021. Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. Archives of toxicology. 96 (1), pp. 287-303. https://doi.org/10.1007/s00204-021-03181-2
Design and Manufacture of One-Size-Fits-All Healthcare Face Shields for the NHS During the COVID-19 Pandemic
Gunputh, U., Williams, G., Leighton, A., Carter, W., Varasteh, H., Pawlik, M., Lu, Y., Sims, R., Lyons, M., Clementson, J., Tripathi, G., Nick Chambers, Matt Roe and Wood, P. 2022. Design and Manufacture of One-Size-Fits-All Healthcare Face Shields for the NHS During the COVID-19 Pandemic. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.4258668
Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019
Mhango, C, Mandolo, J.J, Chinyama, E, Wachepa, R, Kanjerwa, O, Malamba-Banda, C, Matambo, P.B, Barnes, K.G, Chaguza, C, Shawa, I., Nyaga, M.M, Hungerford, D, Parashar, U.D, Pitzer, V.E, Kamng’ona, A.W, Iturriza-Gomara, M, Cunliffe, N.A and Jere, K.C 2022. Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019. The Journal of Infectious Diseases. 225 (12), pp. 2127 - 2136. https://doi.org/10.1093/infdis/jiaa616
Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi
Stockdale, A.J, Meiring, J.E, Shawa, I., Thindwa, D, Silungwe, N.M, Mbewe, M, Kachala, R, Kreuels, B, Patel, P, Patel, P, Henrion, M.Y.R, Bar-Zeev, N, Swarthout, T.D, Heyderman, R.S, Gordon, S.B, Geretti, A.M and Gordon, M.A 2022. Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi . The Journal of Infectious Diseases. 226 (5), p. 871–880. https://doi.org/10.1093/infdis/jiab562
A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission
Stockdale, A.J, Kreuels, B, Shawa, I.T, Meiring, J.E, Thindwa, D, Silungwe, N.M, Chetcuti, K, Joekes, E, Mbewe, M, Mbale, B, Patel, P, Kachala, R, Patel, P.D, Malewa, J, Finch, P, Davis, C, Shah, R, Tong, L, Filipe, A.D.S, Thomson, E.C, Geretti, A.M and Gordon, M.A 2022. A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission. Journal of Viral Hepatitis. 29 (4), p. 252–262. https://doi.org/10.1111/jvh.13646
Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis
Shawa, I.T, Sheridan, D.A, Shawa, I.T, Thomas, E.L, Felmlee, D.J, Bridge, S.H, Neely, D, Cobbold, J.F, Holmes, E, Bassendine, M.F and Taylor-Robinson, S.D 2022. Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis. Scientific Reports . 12 (5562). https://doi.org/10.1038/s41598-022-09588-w
Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines
Benedicto-Matambo, P, Bines, J.E, Malamba-Banda, Chikondi, Shawa, I., Barnes, K, Kamng'ona, A.W, Hungerford, D, Jambo, K.C, Iturriza-Gomara, M, Cunliffe, N.A, Flanagan, K.L and Jere, K.C 2022. Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines. Vaccines. 10 (3), p. 418. https://doi.org/10.3390/vaccines10030418
Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Llewellyn, S. V., Kermanizadeh, A., Ude, V., Jacobsen, N. R., Conway, G. E., Shah, U. K., Niemeijer, M., van de Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G. J. S. and Doak, S. H. 2022. Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in vitro. 85 (105473), pp. 1-9. https://doi.org/10.1016/j.tiv.2022.105473
The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment.
Kermanizadeh, A. 2022. The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment. Particle and Fibre Toxicology. 19 (32). https://doi.org/10.1186/s12989-022-00476-9
Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.
Kermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki 2022. Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology. 15 (10). https://doi.org/10.1080/17435390.2021.2020350
Advancing the global public health agenda for NAFLD: a consensus statement
Shawa, I. and Consortium 2021. Advancing the global public health agenda for NAFLD: a consensus statement. Nature Reviews. Gastroenterology and Hepatology. 19 (1), pp. 60-78. https://doi.org/10.1038/s41575-021-00523-4
The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?
Shawa, I. and Consortium 2021. The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge? Journal of Hepatology. 76 (4), pp. 771-780. https://doi.org/DOI:10.1016/j.jhep.2021.10.025
Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi
Mandolo, J.J, Henrion, M.Y.R, Mhango, C, Chinyama, E, Wachepa, R, Kanjerwa, O, Malamba-Banda,C, Shawa, I., Hungerford, D, Kamng’ona, A.W, Iturriza-Gomara, M, Cunliffe, N.A and Jere, K.C 2021. Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi. Viruses. 13 (12). https://doi.org/10.3390/v13122491
Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi
Stockdale, A.J, Silungwe, N.M, Shawa, I, Kreuels, B, Gordon, M.A and Geretti, A.M 2021. Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi. BMC Infectious Diseases. 21, p. 487. https://doi.org/10.1186/s12879-021-06134-3
Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing?
Kermanizadeh, A. and Moritz, W. 2020. Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition . 9 (1), pp. 103-105. https://doi.org/10.21037/hbsn.2019.09.09
A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs
Ali Kermanizadeh, Leagh G Powell and Vicki Stone 2020. A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs. Journal of Toxicology and Environmental Health, Part B. Vol 23 (Issue 4), pp. 137-176. https://doi.org/10.1080/10937404.2020.1751756
Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?
Kermanizadeh, A. 2020. Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition. Vol 9 (Issue 1). https://doi.org/10.21037/hbsn.2019.09.09
A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Ali Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller 2020. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. Vol 4 (Issue 2, Article: 2000186). https://doi.org/10.1002/adtp.202000186
PWE-001 field cancerisation theory in colorectal cancer (crc): what role do fibroblast growth factors have?
Patel, A, Williams, N, Nwokolo, C, Tripathi, G and Arasaradnam, R 2014. PWE-001 field cancerisation theory in colorectal cancer (crc): what role do fibroblast growth factors have? Gut. https://doi.org/10.1136/gutjnl-2014-307263.261
Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids
Jackisch, L, Kumsaiyai, W, Moore, J.D, Al-Daghri, N, Kyrou, I, Barber, T.M, Randeva, H, Kumar, S, Tripathi, G and McTernan, P.G 2018. Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia. https://doi.org/10.1007/s00125-018-4558-6
Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration
Voyias, P, Antonysunil, A, Kumasaiyai, W, Kyrou, I, Vrbikova, J, Hainer, V, Fried, M, Sramkova, P, Saravanan, P, Kumar, S, McTernan, P and Tripathi, G 2014. Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration. bioscientifica. https://doi.org/10.1530/endoabs.34.P269
A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention
Al-Disi, D, Al-Daghri, N, Khan, N, Alsaif, M, Alfadda, A, Sabico, S, Tripathi, G and McTernan, P 2014. A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention. bioscientifica. https://doi.org/10.1530/endoabs.34.P223
Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro
Pushpakom, S.P, Adaikalakoteswari, A, Owen, A, Back, D.J, Tripathi, G, Kumar, S, McTernan, P and Pirmohamed, M 2018. Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. Diabetes and Vascular Disease Research. https://doi.org/10.1177/1479164118757924
Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients
Al-Daghri, N.M, Mohammed, A.K, Al-Attas, O.S, Ansari, M.G.A, Wani, K, Hussain, S.D, Sabico, S, Tripathi, G and Alokail, M.S 2017. Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients. Scientific Reports. https://doi.org/10.1038/s41598-017-08621-7
Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer
Krishnaswamy, S, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2015. Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer. International Journal of Clinical and Experimental Medicine.
Elevated cord leptin from low B12 mothers predicts birth weight
Antonysunil, A, Vatish, M, Lawson, A, Wood, C, Sivakumar, K, Webster, C, Anderson, N, McTernan, P, Tripathi, G and Saravanan, P 2014. Elevated cord leptin from low B12 mothers predicts birth weight. bioscientifica. https://doi.org/10.1530/endoabs.34.P262
PWE-254 Is the macroscopically normal mucosa (MNM) around colorectal cancer really ‘normal’?
Patel, A, Fang, Y, Moore, J, Williams, N, Tripathi, G and Arasaradnam, R 2015. PWE-254 Is the macroscopically normal mucosa (MNM) around colorectal cancer really ‘normal’? Gut. https://doi.org/10.1136/gutjnl-2015-309861.700
Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects
Piya, M, Reddy, N, Campbell, A, Hattersley, J, Halder, L, Tripathi, G, Tahrani, A, Kumar, S, Barber, T and McTernan, P 2014. Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects. bioscientifica. https://doi.org/10.1530/endoabs.34.P226
Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing
Krishnaswamy, S, Mohammed, A.K, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2017. Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing. BMC Cancer. https://doi.org/10.1186/s12885-017-3747-x
Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines
Krishnaswamy, S, Bukhari, I, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2018. Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines. Gene. https://doi.org/10.1016/j.gene.2018.09.027
Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2
Al‐Daghri, N.M, Alokail, M.S, Rahman, S, Amer, O.E, Al‐Attas, O.S, Alfawaz, H, Tripathi, G, Sabico, S., Chrousos, G.P, McTernan, P.G and Piya, M.K 2015. Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. European Journal of Clinical Investigation. https://doi.org/10.1111/eci.12468
Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15–19 in lung cancer
Krishnaswamy, S, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2015. Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15–19 in lung cancer. Lung Cancer. https://doi.org/10.1016/j.lungcan.2015.12.002
Field cancerisation in colorectal cancer: A new frontier or pastures past?
Patel, A, Tripathi, G, Gopalakrishnan, K, Williams, N and Arasaradnam, R.P 2015. Field cancerisation in colorectal cancer: A new frontier or pastures past? World Journal of Gastroenterology. https://doi.org/10.3748/wjg.v21.i13.3763
Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells
Murphy, A, Jackisch, L., Azharian, S, Aladel, A, Barker, G, Tripathi, G, Chappell, M and McTernan, P 2014. Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells. bioscientifica. https://doi.org/10.1530/endoabs.44.P191
Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss
Kumsaiyai, W, Al-Daghri, N, Kyrou, I, Vrbikova, J, Hainer, V, Fried, M, Sramkova, P, Barber, T, S Kumar, Tripathi, G and McTernan, P 2014. Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss. bioscientifica. https://doi.org/10.1530/endoabs.34.P238
Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes
Jackisch, L, Murphy, A, Al-Daghri, N, McTernan, P, Randeva, H and Tripathi, G 2014. Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes. bioscientifica. https://doi.org/10.1530/endoabs.44.P193
Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3
Adaikalakoteswari, A, Finer, S, Voyias, P.D, McCarthy, M, Vatish, M, Moore, J, Smart-Halajko, M, Bawazeer, N, Al-Daghri, N.M, McTernan, P.G, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3. American Diabetes Association.
Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks
Finer, S, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks. Norwich Research ParK.
The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes
Piya, Milan K, Harte, A. L, Sivakumar, K, Tripathi, G, Voyias, P. D, James, S, Sabico, S, Al-Daghri, N, M, Saravanan, P, Barber, T. M, Kumar, S, Vatish, M and McTernan, P. G 2014. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. American Journal of Physiology Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00308.2013
Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.
Adaikalakoteswari, A, Jayashri, R, Sukumar, N, Venkataraman, H, Pradeepa, R, Gokulakrishnan, K, Anjana, R.M, McTernan, P.G, Tripathi, G, Patel, V and Kumar, S. 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-014-0129-4
Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK
Adaikalakoteswari, A, Vatish, M, Lawson, A, Wood, C, Sivakumar, K, McTernan, P, Webster, C, Anderson, N, Yajnik, C, Tripathi, G and Saravanan, P 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients. https://doi.org/10.3390/nu7042401
Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly.
Reddy, N.L, Peng, C, Carreira, M.C, Halder, L, Hattersley, J, Piya, M.K, Tripathi, G, Randeva, H.S, Casanueva, F.F, McTernan, P.G and Kumar, S 2014. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Cinical Endocrinology. https://doi.org/10.1111/cen.12652
Maternal inheritance of circulating irisin in humans.
Al-Daghri, N.M, Al-Attas, O.S, Alokail, M.S, Alkharfy, K.M, Yousef, M, Vinodson, B, Amer, O.E, Alnaami, A.M, Sabico, S, Tripathi, G and Piya, M.K. 2014. Maternal inheritance of circulating irisin in humans. Clincal Science. https://doi.org/10.1042/CS20130426
Surface charge visualization at viable living cells
Perry, D, Paulose Nadappuram, B, Momotenko, D, Voyias, P.D, Page, A, Tripathi, G, Frenguelli, B.G and Unwin, P.R 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b13153
Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery.
de la Escalera, L.M, Kyrou, I, Vrbikova, J, Hainer, V, Sramkova, P, Fried, M, Piya, M.K, Kumar, S, Tripathi, G and McTernan, P.G 2017. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine. https://doi.org/10.1186/s12916-017-0797-5
Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation.
Reddy, N.L, Jones, T.A, Wayte, S.C, Adesanya, O, Sankar, S, Yeo, Y.C, Tripathi, G, McTernan, P.G, Randeva, H.S, Kumar, S and Hutchinson, C.E 2014. Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/jc.2013-2036
Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases.
Al-Disi, D, A-Daghri, N, Khan, N, Alfadda, A, Sallam, R, Alsaif, M, Sabico, S, Tripathi, G and McTernan, P 2015. Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases. Nutrients. https://doi.org/10.3390/nu7085290
Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes.
Hu, J, Kyrou, I, Tan, B.K, Dimitriadis, G.K, Ramanjaneya, M, Tripathi, G, Patel, V, James, S, Kawan, M, Chen, J and Randeva, H.S 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology. https://doi.org/10.1210/en.2015-1944
Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects
Al-Daghri, N.M, Rahman, S, Sabico, S, Yakout, S, Wani, K, Al-Attas, O.S, Saravanan, P, Tripathi, G, McTernan, P.G and Alokail, M.S 2016. Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients. https://doi.org/10.3390/nu8090460
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
Kermanizadeh, A., Brown, D. M., Moritz, W. and Stone, V. 2019. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. Scientific Reports. 9 (7295), pp. 1-9. https://doi.org/10.1038/s41598-019-43870-8
The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials
Ali Kermanizadeh, David M. Brown and Vicki Stone 2019. The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials. PLos ONE. Vol 14 (Issue 8). https://doi.org/10.1371/journal.pone.0220974
Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencatti, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas 2019. Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications. https://doi.org/10.1101/647347
Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone 2019. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and Fibre Toxicology. Vol 16 (Issue 1), p. Article: 42. https://doi.org/10.1186/s12989-019-0326-0
Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Løhr M, Kermanizadeh A, Loft S, Ebbehøj N, Hansen ÅM, Pedersen PB, Koponen IK, Nørskov EC, Møller P and Vogel U 2018. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. Vol 33 (Issue 1), pp. 105 - 115. https://doi.org/10.1093/mutage/gex021
Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Løhr M, Kermanizadeh A, Loft S, Ebbehøj NE, Hansen ÅM, Kalevi Koponen I, Nørskov EC and Møller P 2018. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environmental and molecular mutagenesis. Vol 59 (Issue 6), pp. 539-548. https://doi.org/10.1002/em.22193
Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.
Jantzen K, Jensen A, Kermanizadeh A, Elholm G, Sigsgaard T, Møller P, Roursgaard M and Loft S 2018. Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects. Toxicological sciences : an official journal of the Society of Toxicology. Vol 163 (Issue 2), p. 353–363. https://doi.org/10.1093/toxsci/kfy027
Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles.
Audureau É, Simon-Deckers A, Franco-Montoya ML, Annangi B, Kermanizadeh A, Boczkowski J and Lanone S 2018. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Scientific Reports. Vol 8 (Issue 1, Article: 8554). https://doi.org/10.1038/s41598-018-26988-z
Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice. Toxicological Sciences. Vol 158 (Issue 1), pp. 176 - 187. https://doi.org/10.1093/toxsci/kfx080
Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis
Kermanizadeh, A., Jantzen, K., Ward, M.B., Durhuus, J.A., Juel Rasmussen, L., Loft, S. and Møller, P. 2017. Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology. Vol 11 (Issue 2), pp. 184-200. https://doi.org/10.1080/17435390.2017.1279359
A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.
Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845
Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. Vol 3 (Issue 11, Article: e00458). https://doi.org/10.1016/j.heliyon.2017.e00458
Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials
Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35
Nanotoxicology: Focus on nanomedicine
Johnston, H., Kermanizadeh, A. and Stone, V. Raj Bawa, Gerald F. Audette and Brian Reese (ed.) 2016. Nanotoxicology: Focus on nanomedicine. New York Routledge.
Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide
Christophersen, D.V., Jacobsen, N.R., Jensen, D.M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Voge, U., Wallin, H. and Møller, P. 2016. Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLos ONE. Vol 11 (Issue 8, Article: e0160731). https://doi.org/10.1371/journal.pone.0160731
Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles
Vranic, S., Gosens, I., Jacobsen, N.R., Jensen, K.A., Bokkers, B., Kermanizadeh, A., Stone, V., Baeza-Squiban, A., Cassee, F.R., Tran, L. and Boland, S. 2016. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Archives of toxicology. Vol 91 (Issue 1), pp. 353 - 363. https://doi.org/10.1007/s00204-016-1673-3
Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells
Kermanizadeh, A., Villadsen, K., Østrem, R.G., Jensen, K.J., Møller, P. and Loft, S. 2016. Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells. Basic and Clinical Pharmacology and Toxicology. Vol 120 (Issue 4), pp. 380 - 389. https://doi.org/10.1111/bcpt.12692
Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
Møller, P., Christophersen, D.V., Jacobsen, N.R., Skovmand, A., Gouveia, A.C.D., Andersen, M.H.G., Kermanizadeh, A., Jensen, D.M., Danielsen, P.H., Roursgaard, M., Jantzen, K. and Loft, S. 2016. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology. Vol 46 (Issue 5), pp. 437-476. https://doi.org/10.3109/10408444.2016.1149451
A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges
Kermanizadeh, A., Gosens, I., MacCalman, L., Johnston, H., Danielsen, P.H., Jacobsen, N.R., Lenz, A.-G., Fernandes, T., Schins, R.P.F., Cassee, F.R., Wallin, H., Kreyling, W., Stoeger, T., Loft, S., Møller, P., Tran, L. and Stone, V. 2016. A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health - Part B: Critical Reviews. Vol 19 (Issue 1), pp. 1-28. https://doi.org/10.1080/10937404.2015.1126210
An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine
Matthew S.P. Boyles, Leagh G. Powell, Ali Kermanizadeh, Helinor J. Johnston, Barbara Rothen-Rutishauser, Vicki Stone and Martin J.D. Clift 2016. An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. in: Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production Wiley Online Library. pp. 443-468
Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes.
Borghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P 2016. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes. Mutagenesis. Vol 32 (Issue 1), p. 173–180. https://doi.org/10.1093/mutage/gew036
Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats
Løhr, M., Folkmann, J.K., Sheykhzade, M., Jensen, L.J., Kermanizadeh, A., Loft, S. and Møller, P. 2015. Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLos ONE. Vol 10 (Issue 3, Article: e0118773). https://doi.org/10.1371/journal.pone.0118773
Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review
Kermanizadeh, A., Balharry, D., Wallin, H., Loft, S. and Møller, P. 2015. Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review. Critical Reviews in Toxicology. Vol 45 (Issue 10), pp. 837-872. https://doi.org/10.3109/10408444.2015.1058747
Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories
Jacobsen, N.R., Stoeger, T., van den Brule, S., Saber, A.T., Beyerle, A., Vietti, G., Mortensen, A., Szarek, J., Budtz, H.C., Kermanizadeh, A., Banerjee, A., Ercal, N., Vogel, U., Wallin, H. and Møller, P. 2015. Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories. Food and Chemical Toxicology. Vol 85 (Nov 2015), pp. 84 - 95. https://doi.org/10.1016/j.fct.2015.08.008
Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice
Gosens, I., Kermanizadeh, A., Jacobsen, N.R., Lenz, A.-G., Bokkers, B., De Jong, W.H., Krystek, P., Tran, L., Stone, V., Wallin, H., Stoeger, T. and Cassee, F.R. 2015. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLos ONE. Vol 10 (Issue 5, Article: 0126934). https://doi.org/10.1371/journal.pone.0126934
The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation
Nattrass, C., Horwell, C.J., Damby, D.E., Kermanizadeh, A., Brown, D.M. and Stone, V. 2015. The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation. Journal of Occupational Medicine and Toxicology. Vol 10 (Issue 1, Article: 23). https://doi.org/10.1186/s12995-015-0064-7
Nanotoxicology
Dominique Balharry, Eva Gubbins, Helinor Johnston, Kermanizadeh, A. and Vicki Stone 2015. Nanotoxicology. in: Nanoparticles in the Lung Boca Raton CRC Press.
The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review
Kermanizadeh, A., Chauché, C., Brown, D.M., Loft, S. and Møller, P. 2014. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 111 - 124. https://doi.org/10.1002/em.21926
Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells
Cao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P. 2014. Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells. International Journal of Toxicology. Vol 34 (Issue 1), pp. 67 - 76. https://doi.org/10.1177/1091581814560032
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Belade, E., Chrusciel, S., Armand, L., Simon-Deckers, A., Bussy, C., Caramelle, P., Gagliolo, J.-M., Boyer, L., Lanone, S., Pairon, J.-C., Kermanizadeh, A. and Boczkowski, J. 2014. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. Vol 89 (Issue 9), pp. 1543 - 1556. https://doi.org/10.1007/s00204-014-1324-5
Role of oxidative stress in carbon nanotube-generated health effects
Møller, P., Christophersen, D.V., Jensen, D.M., Kermanizadeh, A., Roursgaard, M., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Role of oxidative stress in carbon nanotube-generated health effects. Archives of toxicology. Vol 88 (Issue 11), pp. 1939 - 1964. https://doi.org/10.1007/s00204-014-1356-x
Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals
Møller, P., Jensen, D.M., Christophersen, D.V., Kermanizadeh, A., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Karottki, D.G., Roursgaard, M., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 97 - 110. https://doi.org/10.1002/em.21899
Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure
Møller, P., Hemmingsen, J.G., Jensen, D.M., Danielsen, P.H., Karottki, D.G., Jantzen, K., Roursgaard, M., Cao, Y., Kermanizadeh, A., Klingberg, H., Christophersen, D.V., Hersoug, L.-G. and Loft, S. 2014. Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure. Mutagenesis. Vol 30 (Issue 1), p. 67–83. https://doi.org/10.1093/mutage/geu035
Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
Kermanizadeh, A., Løhr, M., Roursgaard, M., Messner, S., Gunness, P., Kelm, J.M., Møller, P., Stone, V. and Loft, S. 2014. Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model. Particle and Fibre Toxicology. Vol 11 (Issue 1, Article: 56). https://doi.org/10.1186/s12989-014-0056-2
The role of Kupffer cells in the hepatic response to silver nanoparticles.
Kermanizadeh, A., Chauché, C., Balharry, D., Brown, D. M., Kanase, N., Boczkowski, J., Lanone, S. and Stone, V. 2013. The role of Kupffer cells in the hepatic response to silver nanoparticles. Nanotoxicology. 1 (1), pp. 149-154. https://doi.org/10.3109/17435390.2013.866284