Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials

Book chapter

Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35
AuthorsKermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift
EditorsPeter Grunwald
Abstract

This chapter focuses on current knowledge available regarding nanomaterial (NM)-induced adverse effects towards human health. It outlines outstanding issues that associated with the field of nanotoxicology in order to offer suggestions that might improve experimental design towards future research. With the ever-increasing sources and proposed applications of NMs, humans are continuously and inevitably exposed to NMs of all shapes and sizes. In terms of human exposure, the predominant focus, historically, of the NM toxicology field has been towards understanding the pulmonary effects of NMs. The adverse effects in terms of cardiovascular effects are invariably only observed in experimental animals given relatively high doses, often by instillation into the lungs or the direct injection into the blood. For blood-borne materials, the phagocytic Kupffer cells can be considered as a key clearance system with subsequent potential for accumulation of dose in the liver.

KeywordsNanomaterials; Nanotoxicology; livers; lungs; doses
Page range35
Year2017
Book titleBiocatalysis and Nanotechnology
PublisherTaylor & Francis
Place of publicationNew York
Edition1st
ISBN9781315196602
978-981461369-9
Digital Object Identifier (DOI)https://doi.org/10.1201/9781315196602
Web address (URL)https://www.taylorfrancis.com/chapters/edit/10.1201/9781315196602-23/overview-current-knowledge-challenges-associated-human-exposure-nanomaterials-ali-kermanizadeh-kim-jantzen-astrid-skovmand-ana-gouveia-nicklas-jacobsen-vicki-stone-martin-clift
Output statusPublished
Publication dates
Online13 Oct 2017
Publication process dates
Deposited12 Jun 2023
JournalBiocatalysis and Nanotechnology
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