AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research
Journal article
Authors | Yu, H., O'Neill, S. and Kermanizadeh, A. |
---|---|
Abstract | The fusion of machine learning and biomedical research offers novel ways to understand, diagnose, and treat various health conditions. However, the complexities of biomedical data, coupled with the intricate process of developing and deploying machine learning solutions, often pose significant challenges to researchers in these fields. Our pivotal achievement in this research is the introduction of the Automatic Semantic Machine Learning Microservice Framework (AIMS). AIMS addresses these challenges by automating various stages of the machine learning pipeline, with a particular emphasis on the ontology of machine learning services tailored for the biomedical domain. This ontology encompasses everything from task representation, service modeling, and knowledge acquisition to knowledge reasoning and the establishment of a self-supervised learning policy. Our framework has been crafted to prioritize model interpretability, integrate domain knowledge effortlessly, and handle biomedical data with efficiency. Additionally, AIMS boasts a distinctive feature: it leverages self-supervised knowledge learning through reinforcement learning techniques, paired with an ontology-based policy recording schema. This enables it to autonomously generate, fine-tune, and continually adapt to machine learning models, especially when faced with new tasks and data. Our work has two standout contributions of demonstrating that machine learning processes in the biomedical domain can be automated, while integrating a rich domain knowledge base and providing a way for machines to have a self-learning ability, ensuring they handle new tasks effectively. To showcase AIMS in action, we've highlighted its prowess in three case studies from biomedical tasks. These examples emphasize how our framework can simplify research routines, uplift the caliber of scientific exploration, and set the stage for notable advances. |
Keywords | AI automation; Biomedical; Machine learning |
Year | 2023 |
Journal | Bioengineering |
Journal citation | 10 (10), pp. 1-18 |
Publisher | MDPI Open Access Journals |
ISSN | 2306-5354 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/bioengineering10101134 |
Web address (URL) | https://www.mdpi.com/2306-5354/10/10/1134 |
Accepted author manuscript | License File Access Level Open |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 27 Sep 2023 |
Publication process dates | |
Accepted | 25 Sep 2023 |
Deposited | 09 Oct 2023 |
https://repository.derby.ac.uk/item/q199v/aims-an-automatic-semantic-machine-learning-microservice-framework-to-support-biomedical-and-bioengineering-research
Download files
Accepted author manuscript
MDPI_Bioengineering (3).pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
Publisher's version
MDPI_Bioengineering (3).pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
65
total views58
total downloads6
views this month0
downloads this month
Export as
Related outputs
A comprehensive toxicological analysis of panel of unregulated e-cigarettes to human health
Guraka, A., Mierlea, S., Drake, S., Shawa, T. S., Waldron, S., Corcoran, M., Dowse, D., Walkman, D., Burn, L., Sivasubramaniam, S. and Kermanizadeh, A. 2024. A comprehensive toxicological analysis of panel of unregulated e-cigarettes to human health. Toxicology. 509, pp. 1-12. https://doi.org/10.1016/j.tox.2024.153964A Review of Toxicological Profile of Fentanyl—A 2024 Update
Kermanizadeh, A. and Williamson, J. 2024. A Review of Toxicological Profile of Fentanyl—A 2024 Update. Toxics. 12 (10), pp. 1-14. https://doi.org/10.3390/toxics12100690Co-Culture of Gut Bacteria and Metabolite Extraction Using Fast Vacuum Filtration and Centrifugation
Guraka, A., Duff, R., Waldron, J., Tripathi, G. and Kermanizadeh, A. 2024. Co-Culture of Gut Bacteria and Metabolite Extraction Using Fast Vacuum Filtration and Centrifugation. Methods and Protocols. 7 (74), pp. 1-13. https://doi.org/10.3390/mps7050074Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure
Guraka, A., Souch, G., Duff, R., Brown, D., Moritz, W. and Ali Kermanizadeh 2024. Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure. Chemosphere. pp. 1-36. https://doi.org/10.1016/j.chemosphere.2024.143032Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives
Hristozov, D., Badetti, E., Bigini, P., Brunelli, A., Dekkers, S., Diomede, L., Doak, S. K., Fransman, W., Gajewicz-Skretna, A., Giubilato, E., Gómez-Cuadrado, L., Grafström, R., Gutleb, R. C., Halappanavar, S., Hischier, R., Hunt, N., Katsumiti, A., Kermanizadeh, A., Marcomini, A., Moschini, E., Oomen, E., Pizzol, L., Rumbo, C., Schmid, O., Shandilya, N., Stone, V., Stoycheva, S, Stoeger, T., Merino, B. S., Tran, L., Tsiliki, G., Vogel, U. B., Wohlleben, W. and Zabeo, A. 2024. Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives. NanoImpact. pp. 1-48. https://doi.org/10.1016/j.impact.2024.100523Explainable DCNN Decision Framework for Breast Lesion Classification from Ultrasound Images Based on Cancer Characteristics
AlZoubi, A., Eskandari, A., Yu, H. and Du, H. 2024. Explainable DCNN Decision Framework for Breast Lesion Classification from Ultrasound Images Based on Cancer Characteristics . Bioengineering. 11 (5), pp. 1-23. https://doi.org/10.3390/bioengineering11050453An Experimental Study of Integrating Fine-tuned LLMs and Prompts for Enhancing Mental Health Support Chatbot System
Yu, H. and McGuinness, S. 2024. An Experimental Study of Integrating Fine-tuned LLMs and Prompts for Enhancing Mental Health Support Chatbot System. Journal of Medical Artificial Intelligence. pp. 1-16. https://doi.org/10.21037/jmai-23-1Deep Recognition of Chinese Herbal Medicines Based on a Caputo Fractional Order Convolutional Neural Network
Tao Li, Jiawei Yang, Chenxi Li, Lulu Lv, Kang Liu, Zhipeng Yuan, Youyong Li, Hongqing Yu and Yu, H. 2024. Deep Recognition of Chinese Herbal Medicines Based on a Caputo Fractional Order Convolutional Neural Network. International Workshop on Internet of Things of Big Data for Healthcare. Springer. https://doi.org/10.1007/978-3-031-52216-1_4Evaluation of Integrated XAI Frameworks for Explaining Disease Prediction Models in Healthcare
Yu, H., Adebola Alaba and Ebere Eziefuna 2024. Evaluation of Integrated XAI Frameworks for Explaining Disease Prediction Models in Healthcare. International Workshop on Internet of Things of Big Data for Healthcare. Springer. https://doi.org/10.1007/978-3-031-52216-1_2Modular reactors: What can we learn from modular industrial plants and off site construction research
Paul Wrigley, Paul Wood, Daniel Robertson, Jason Joannou, Sam O'Neill and Richard hall 2023. Modular reactors: What can we learn from modular industrial plants and off site construction research. Nuclear Engineering and Technology. 56 (1), pp. 1-11. https://doi.org/10.1016/j.net.2023.07.023Attention Enhanced Siamese Neural Network for Face Validation
Yu, H. 2023. Attention Enhanced Siamese Neural Network for Face Validation. Artificial Intelligence and Applications. 2 (1), pp. 21-27. https://doi.org/10.47852/bonviewAIA32021018IoTBDH-2023: The 5th International Workshop on Internet of Things of Big Data for Healthcare
Qi, J., Yu, H., Yang, P., Yang, Y. and Pang, Z. 2023. IoTBDH-2023: The 5th International Workshop on Internet of Things of Big Data for Healthcare. 32nd ACM International Conference on Information and Knowledge Management (CIKM’23), Birmingham, UK. ACM. https://doi.org/10.1145/3583780.3615299Drug induced liver injury - a 2023 update.
Allison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A. 2023. Drug induced liver injury - a 2023 update. Journal of Toxicology and Environmental Health, Part B. 26 (8), pp. 1-26. https://doi.org/10.1080/10937404.2023.2261848
Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH.
Kermanizadeh, Ali, Valli, Jessica, Sanchez, Katarzyna, Hutter, Simon, Pawlowska, Agnieszka, Whyte, Graeme, Moritz, Wolfgang and Stone, Vicki 2021. Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. Archives of toxicology. 96 (1), pp. 287-303. https://doi.org/10.1007/s00204-021-03181-2Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Llewellyn, S. V., Kermanizadeh, A., Ude, V., Jacobsen, N. R., Conway, G. E., Shah, U. K., Niemeijer, M., van de Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G. J. S. and Doak, S. H. 2022. Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in vitro. 85 (105473), pp. 1-9. https://doi.org/10.1016/j.tiv.2022.105473The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment.
Kermanizadeh, A. 2022. The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment. Particle and Fibre Toxicology. 19 (32). https://doi.org/10.1186/s12989-022-00476-9Learning Disease Causality Knowledge from Web of Health Data
Yu, H. and Reiff-Marganiec, S. 2022. Learning Disease Causality Knowledge from Web of Health Data. International journal on semantic web and information systems. 18 (1), pp. 1-19. https://doi.org/10.4018/IJSWIS.297145Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.
Kermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki 2022. Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology. 15 (10). https://doi.org/10.1080/17435390.2021.2020350
A mixed-integer linear programming formulation for the modular layout of three-dimensional connected systems
O’Neill, Sam, Wrigley, Paul and Bagdasar, Ovidiu 2021. A mixed-integer linear programming formulation for the modular layout of three-dimensional connected systems. Mathematics and Computers in Simulation. https://doi.org/10.1016/j.matcom.2021.09.019Off-site modular construction and design in nuclear power: A systematic literature review
Wood, P., Wrigley, P., O'Neill, S., R. Hall and D. Robertson 2021. Off-site modular construction and design in nuclear power: A systematic literature review. Progress in Nuclear Energy. https://doi.org/10.1016/j.pnucene.2021.103664Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing?
Kermanizadeh, A. and Moritz, W. 2020. Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition . 9 (1), pp. 103-105. https://doi.org/10.21037/hbsn.2019.09.09A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs
Ali Kermanizadeh, Leagh G Powell and Vicki Stone 2020. A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs. Journal of Toxicology and Environmental Health, Part B. Vol 23 (Issue 4), pp. 137-176. https://doi.org/10.1080/10937404.2020.1751756Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?
Kermanizadeh, A. 2020. Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition. Vol 9 (Issue 1). https://doi.org/10.21037/hbsn.2019.09.09A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Ali Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller 2020. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. Vol 4 (Issue 2, Article: 2000186). https://doi.org/10.1002/adtp.202000186Experimental Disease Prediction Research on Combining Natural Language Processing and Machine Learning
Yu, H. 2020. Experimental Disease Prediction Research on Combining Natural Language Processing and Machine Learning. IEEE 7th International Conference on Computer Science and Network Technology (ICCSNT). IEEE Xplore. https://doi.org/10.1109/iccsnt47585.2019.8962507Dynamic Causality Knowledge Graph Generation for Supporting the Chatbot Healthcare System
Yu, H. 2020. Dynamic Causality Knowledge Graph Generation for Supporting the Chatbot Healthcare System. in: Arai, Kohei, Kapoor, Supriya and Bhatia, Rahul (ed.) Proceedings of the Future Technologies Conference (FTC) 2020, Volume 3 New York Springer.
A generating function approach to the automated evaluation of sums of exponentiated multiples of generalized Catalan number linear combinations.
Larcombe, Peter J. and O'Neill, Sam T. 2018. A generating function approach to the automated evaluation of sums of exponentiated multiples of generalized Catalan number linear combinations. Fibonacci Quarterly.The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
Kermanizadeh, A., Brown, D. M., Moritz, W. and Stone, V. 2019. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. Scientific Reports. 9 (7295), pp. 1-9. https://doi.org/10.1038/s41598-019-43870-8The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials
Ali Kermanizadeh, David M. Brown and Vicki Stone 2019. The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials. PLos ONE. Vol 14 (Issue 8). https://doi.org/10.1371/journal.pone.0220974Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencatti, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas 2019. Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications. https://doi.org/10.1101/647347Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone 2019. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and Fibre Toxicology. Vol 16 (Issue 1), p. Article: 42. https://doi.org/10.1186/s12989-019-0326-0Low-Cost and Data Anonymised City Traffic Flow Data Collection to Support Intelligent Traffic System
Handscombe, J. and Yu, H. 2019. Low-Cost and Data Anonymised City Traffic Flow Data Collection to Support Intelligent Traffic System. Sensors. 19 (2), p. 347. https://doi.org/10.3390/s19020347Semantic Lifting and Reasoning on the Personalised Activity Big Data Repository for Healthcare Research
Yu, H. and Dong, F. 2019. Semantic Lifting and Reasoning on the Personalised Activity Big Data Repository for Healthcare Research. International Journal of Web Engineering and Technology. 14 (2), pp. 103 - 121.Mining Symptom and Disease Web Data with NLP and Open Linked Data
Yu, H. 2019. Mining Symptom and Disease Web Data with NLP and Open Linked Data. 5th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’19) Lisbon, Portugal – August, 2019. https://doi.org/10.11159/mvml19.108
Traffic assignment: methods and simulations for an alternative formulation of the fixed demand problem
Bagdasar, Ovidiu, Berry, Stuart, O’Neill, Sam, Popovici, Nicolae and Raja, Ramachandran 2018. Traffic assignment: methods and simulations for an alternative formulation of the fixed demand problem. Mathematics and Computers in Simulation. https://doi.org/10.1016/j.matcom.2018.08.004Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Løhr M, Kermanizadeh A, Loft S, Ebbehøj N, Hansen ÅM, Pedersen PB, Koponen IK, Nørskov EC, Møller P and Vogel U 2018. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. Vol 33 (Issue 1), pp. 105 - 115. https://doi.org/10.1093/mutage/gex021Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Løhr M, Kermanizadeh A, Loft S, Ebbehøj NE, Hansen ÅM, Kalevi Koponen I, Nørskov EC and Møller P 2018. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environmental and molecular mutagenesis. Vol 59 (Issue 6), pp. 539-548. https://doi.org/10.1002/em.22193Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.
Jantzen K, Jensen A, Kermanizadeh A, Elholm G, Sigsgaard T, Møller P, Roursgaard M and Loft S 2018. Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects. Toxicological sciences : an official journal of the Society of Toxicology. Vol 163 (Issue 2), p. 353–363. https://doi.org/10.1093/toxsci/kfy027Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles.
Audureau É, Simon-Deckers A, Franco-Montoya ML, Annangi B, Kermanizadeh A, Boczkowski J and Lanone S 2018. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Scientific Reports. Vol 8 (Issue 1, Article: 8554). https://doi.org/10.1038/s41598-018-26988-zHepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice. Toxicological Sciences. Vol 158 (Issue 1), pp. 176 - 187. https://doi.org/10.1093/toxsci/kfx080Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis
Kermanizadeh, A., Jantzen, K., Ward, M.B., Durhuus, J.A., Juel Rasmussen, L., Loft, S. and Møller, P. 2017. Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology. Vol 11 (Issue 2), pp. 184-200. https://doi.org/10.1080/17435390.2017.1279359A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.
Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. Vol 3 (Issue 11, Article: e00458). https://doi.org/10.1016/j.heliyon.2017.e00458Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials
Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35