AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research

Journal article


Yu, H., O'Neill, S. and Kermanizadeh, A. 2023. AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research. Bioengineering. 10 (10), pp. 1-18. https://doi.org/10.3390/bioengineering10101134
AuthorsYu, H., O'Neill, S. and Kermanizadeh, A.
Abstract

The fusion of machine learning and biomedical research offers novel ways to understand, diagnose, and treat various health conditions. However, the complexities of biomedical data, coupled with the intricate process of developing and deploying machine learning solutions, often pose significant challenges to researchers in these fields. Our pivotal achievement in this research is the introduction of the Automatic Semantic Machine Learning Microservice Framework (AIMS). AIMS addresses these challenges by automating various stages of the machine learning pipeline, with a particular emphasis on the ontology of machine learning services tailored for the biomedical domain. This ontology encompasses everything from task representation, service modeling, and knowledge acquisition to knowledge reasoning and the establishment of a self-supervised learning policy. Our framework has been crafted to prioritize model interpretability, integrate domain knowledge effortlessly, and handle biomedical data with efficiency. Additionally, AIMS boasts a distinctive feature: it leverages self-supervised knowledge learning through reinforcement learning techniques, paired with an ontology-based policy recording schema. This enables it to autonomously generate, fine-tune, and continually adapt to machine learning models, especially when faced with new tasks and data. Our work has two standout contributions of demonstrating that machine learning processes in the biomedical domain can be automated, while integrating a rich domain knowledge base and providing a way for machines to have a self-learning ability, ensuring they handle new tasks effectively. To showcase AIMS in action, we've highlighted its prowess in three case studies from biomedical tasks. These examples emphasize how our framework can simplify research routines, uplift the caliber of scientific exploration, and set the stage for notable advances.

KeywordsAI automation; Biomedical; Machine learning
Year2023
JournalBioengineering
Journal citation10 (10), pp. 1-18
PublisherMDPI Open Access Journals
ISSN2306-5354
Digital Object Identifier (DOI)https://doi.org/10.3390/bioengineering10101134
Web address (URL)https://www.mdpi.com/2306-5354/10/10/1134
Accepted author manuscript
License
File Access Level
Open
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online27 Sep 2023
Publication process dates
Accepted25 Sep 2023
Deposited09 Oct 2023
Permalink -

https://repository.derby.ac.uk/item/q199v/aims-an-automatic-semantic-machine-learning-microservice-framework-to-support-biomedical-and-bioengineering-research

Download files


Accepted author manuscript
MDPI_Bioengineering (3).pdf
License: CC BY 4.0
File access level: Open


Publisher's version
MDPI_Bioengineering (3).pdf
License: CC BY 4.0
File access level: Open

  • 46
    total views
  • 52
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

A comprehensive toxicological analysis of panel of unregulated e-cigarettes to human health
Guraka, A., Mierlea, S., Drake, S. J., Shawa, T. S., Waldron, S., Corcoran, M., Dowse, D., Walkman, D., Burn, L., Sivasubramaniam, S. and Kermanizadeh, A. 2024. A comprehensive toxicological analysis of panel of unregulated e-cigarettes to human health. Toxicology. 509, pp. 1-12. https://doi.org/10.1016/j.tox.2024.153964
A Review of Toxicological Profile of Fentanyl—A 2024 Update
Kermanizadeh, A. and Williamson, J. 2024. A Review of Toxicological Profile of Fentanyl—A 2024 Update. Toxics. 12 (10), pp. 1-14. https://doi.org/10.3390/toxics12100690
Co-Culture of Gut Bacteria and Metabolite Extraction Using Fast Vacuum Filtration and Centrifugation
Guraka, A., Duff, R., Waldron, J., Tripathi, G. and Kermanizadeh, A. 2024. Co-Culture of Gut Bacteria and Metabolite Extraction Using Fast Vacuum Filtration and Centrifugation. Methods and Protocols. 7 (74), pp. 1-13. https://doi.org/10.3390/mps7050074
Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure
Guraka, A., Souch, G., Duff, R., Brown, D., Moritz, W. and Ali Kermanizadeh 2024. Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure. Chemosphere. pp. 1-36. https://doi.org/10.1016/j.chemosphere.2024.143032
Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives
Hristozov, D., Badetti, E., Bigini, P., Brunelli, A., Dekkers, S., Diomede, L., Doak, S. K., Fransman, W., Gajewicz-Skretna, A., Giubilato, E., Gómez-Cuadrado, L., Grafström, R., Gutleb, R. C., Halappanavar, S., Hischier, R., Hunt, N., Katsumiti, A., Kermanizadeh, A., Marcomini, A., Moschini, E., Oomen, E., Pizzol, L., Rumbo, C., Schmid, O., Shandilya, N., Stone, V., Stoycheva, S, Stoeger, T., Merino, B. S., Tran, L., Tsiliki, G., Vogel, U. B., Wohlleben, W. and Zabeo, A. 2024. Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives. NanoImpact. pp. 1-48. https://doi.org/10.1016/j.impact.2024.100523
Explainable DCNN Decision Framework for Breast Lesion Classification from Ultrasound Images Based on Cancer Characteristics
AlZoubi, A., Eskandari, A., Yu, H. and Du, H. 2024. Explainable DCNN Decision Framework for Breast Lesion Classification from Ultrasound Images Based on Cancer Characteristics . Bioengineering. 11 (5), pp. 1-23. https://doi.org/10.3390/bioengineering11050453
An Experimental Study of Integrating Fine-tuned LLMs and Prompts for Enhancing Mental Health Support Chatbot System
Yu, H. and McGuinness, S. 2024. An Experimental Study of Integrating Fine-tuned LLMs and Prompts for Enhancing Mental Health Support Chatbot System. Journal of Medical Artificial Intelligence. pp. 1-16. https://doi.org/10.21037/jmai-23-1
Deep Recognition of Chinese Herbal Medicines Based on a Caputo Fractional Order Convolutional Neural Network
Tao Li, Jiawei Yang, Chenxi Li, Lulu Lv, Kang Liu, Zhipeng Yuan, Youyong Li, Hongqing Yu and Yu, H. 2024. Deep Recognition of Chinese Herbal Medicines Based on a Caputo Fractional Order Convolutional Neural Network. International Workshop on Internet of Things of Big Data for Healthcare. Springer. https://doi.org/10.1007/978-3-031-52216-1_4
Evaluation of Integrated XAI Frameworks for Explaining Disease Prediction Models in Healthcare
Yu, H., Adebola Alaba and Ebere Eziefuna 2024. Evaluation of Integrated XAI Frameworks for Explaining Disease Prediction Models in Healthcare. International Workshop on Internet of Things of Big Data for Healthcare. Springer. https://doi.org/10.1007/978-3-031-52216-1_2
Modular reactors: What can we learn from modular industrial plants and off site construction research
Paul Wrigley, Paul Wood, Daniel Robertson, Jason Joannou, Sam O'Neill and Richard hall 2023. Modular reactors: What can we learn from modular industrial plants and off site construction research. Nuclear Engineering and Technology. 56 (1), pp. 1-11. https://doi.org/10.1016/j.net.2023.07.023
Attention Enhanced Siamese Neural Network for Face Validation
Yu, H. 2023. Attention Enhanced Siamese Neural Network for Face Validation. Artificial Intelligence and Applications. 2 (1), pp. 21-27. https://doi.org/10.47852/bonviewAIA32021018
IoTBDH-2023: The 5th International Workshop on Internet of Things of Big Data for Healthcare
Qi, J., Yu, H., Yang, P., Yang, Y. and Pang, Z. 2023. IoTBDH-2023: The 5th International Workshop on Internet of Things of Big Data for Healthcare. 32nd ACM International Conference on Information and Knowledge Management (CIKM’23), Birmingham, UK. ACM. https://doi.org/10.1145/3583780.3615299
Drug induced liver injury - a 2023 update.
Allison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A. 2023. Drug induced liver injury - a 2023 update. Journal of Toxicology and Environmental Health, Part B. 26 (8), pp. 1-26. https://doi.org/10.1080/10937404.2023.2261848
Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH.
Kermanizadeh, Ali, Valli, Jessica, Sanchez, Katarzyna, Hutter, Simon, Pawlowska, Agnieszka, Whyte, Graeme, Moritz, Wolfgang and Stone, Vicki 2021. Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. Archives of toxicology. 96 (1), pp. 287-303. https://doi.org/10.1007/s00204-021-03181-2
Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Llewellyn, S. V., Kermanizadeh, A., Ude, V., Jacobsen, N. R., Conway, G. E., Shah, U. K., Niemeijer, M., van de Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G. J. S. and Doak, S. H. 2022. Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in vitro. 85 (105473), pp. 1-9. https://doi.org/10.1016/j.tiv.2022.105473
The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment.
Kermanizadeh, A. 2022. The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment. Particle and Fibre Toxicology. 19 (32). https://doi.org/10.1186/s12989-022-00476-9
Learning Disease Causality Knowledge from Web of Health Data
Yu, H. and Reiff-Marganiec, S. 2022. Learning Disease Causality Knowledge from Web of Health Data. International journal on semantic web and information systems. 18 (1), pp. 1-19. https://doi.org/10.4018/IJSWIS.297145
Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.
Kermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki 2022. Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology. 15 (10). https://doi.org/10.1080/17435390.2021.2020350
A mixed-integer linear programming formulation for the modular layout of three-dimensional connected systems
O’Neill, Sam, Wrigley, Paul and Bagdasar, Ovidiu 2021. A mixed-integer linear programming formulation for the modular layout of three-dimensional connected systems. Mathematics and Computers in Simulation. https://doi.org/10.1016/j.matcom.2021.09.019
Off-site modular construction and design in nuclear power: A systematic literature review
Wood, P., Wrigley, P., O'Neill, S., R. Hall and D. Robertson 2021. Off-site modular construction and design in nuclear power: A systematic literature review. Progress in Nuclear Energy. https://doi.org/10.1016/j.pnucene.2021.103664
Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing?
Kermanizadeh, A. and Moritz, W. 2020. Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition . 9 (1), pp. 103-105. https://doi.org/10.21037/hbsn.2019.09.09
A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs
Ali Kermanizadeh, Leagh G Powell and Vicki Stone 2020. A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs. Journal of Toxicology and Environmental Health, Part B. Vol 23 (Issue 4), pp. 137-176. https://doi.org/10.1080/10937404.2020.1751756
Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?
Kermanizadeh, A. 2020. Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition. Vol 9 (Issue 1). https://doi.org/10.21037/hbsn.2019.09.09
A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Ali Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller 2020. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. Vol 4 (Issue 2, Article: 2000186). https://doi.org/10.1002/adtp.202000186
Experimental Disease Prediction Research on Combining Natural Language Processing and Machine Learning
Yu, H. 2020. Experimental Disease Prediction Research on Combining Natural Language Processing and Machine Learning. IEEE 7th International Conference on Computer Science and Network Technology (ICCSNT). IEEE Xplore. https://doi.org/10.1109/iccsnt47585.2019.8962507
Dynamic Causality Knowledge Graph Generation for Supporting the Chatbot Healthcare System
Yu, H. 2020. Dynamic Causality Knowledge Graph Generation for Supporting the Chatbot Healthcare System. in: Arai, Kohei, Kapoor, Supriya and Bhatia, Rahul (ed.) Proceedings of the Future Technologies Conference (FTC) 2020, Volume 3 New York Springer.
A generating function approach to the automated evaluation of sums of exponentiated multiples of generalized Catalan number linear combinations.
Larcombe, Peter J. and O'Neill, Sam T. 2018. A generating function approach to the automated evaluation of sums of exponentiated multiples of generalized Catalan number linear combinations. Fibonacci Quarterly.
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
Kermanizadeh, A., Brown, D. M., Moritz, W. and Stone, V. 2019. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. Scientific Reports. 9 (7295), pp. 1-9. https://doi.org/10.1038/s41598-019-43870-8
The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials
Ali Kermanizadeh, David M. Brown and Vicki Stone 2019. The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials. PLos ONE. Vol 14 (Issue 8). https://doi.org/10.1371/journal.pone.0220974
Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencatti, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas 2019. Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications. https://doi.org/10.1101/647347
Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone 2019. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and Fibre Toxicology. Vol 16 (Issue 1), p. Article: 42. https://doi.org/10.1186/s12989-019-0326-0
Low-Cost and Data Anonymised City Traffic Flow Data Collection to Support Intelligent Traffic System
Handscombe, J. and Yu, H. 2019. Low-Cost and Data Anonymised City Traffic Flow Data Collection to Support Intelligent Traffic System. Sensors. 19 (2), p. 347. https://doi.org/10.3390/s19020347
Semantic Lifting and Reasoning on the Personalised Activity Big Data Repository for Healthcare Research
Yu, H. and Dong, F. 2019. Semantic Lifting and Reasoning on the Personalised Activity Big Data Repository for Healthcare Research. International Journal of Web Engineering and Technology. 14 (2), pp. 103 - 121.
Mining Symptom and Disease Web Data with NLP and Open Linked Data
Yu, H. 2019. Mining Symptom and Disease Web Data with NLP and Open Linked Data. 5th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’19) Lisbon, Portugal – August, 2019. https://doi.org/10.11159/mvml19.108
Traffic assignment: methods and simulations for an alternative formulation of the fixed demand problem
Bagdasar, Ovidiu, Berry, Stuart, O’Neill, Sam, Popovici, Nicolae and Raja, Ramachandran 2018. Traffic assignment: methods and simulations for an alternative formulation of the fixed demand problem. Mathematics and Computers in Simulation. https://doi.org/10.1016/j.matcom.2018.08.004
Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Løhr M, Kermanizadeh A, Loft S, Ebbehøj N, Hansen ÅM, Pedersen PB, Koponen IK, Nørskov EC, Møller P and Vogel U 2018. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. Vol 33 (Issue 1), pp. 105 - 115. https://doi.org/10.1093/mutage/gex021
Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Løhr M, Kermanizadeh A, Loft S, Ebbehøj NE, Hansen ÅM, Kalevi Koponen I, Nørskov EC and Møller P 2018. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environmental and molecular mutagenesis. Vol 59 (Issue 6), pp. 539-548. https://doi.org/10.1002/em.22193
Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.
Jantzen K, Jensen A, Kermanizadeh A, Elholm G, Sigsgaard T, Møller P, Roursgaard M and Loft S 2018. Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects. Toxicological sciences : an official journal of the Society of Toxicology. Vol 163 (Issue 2), p. 353–363. https://doi.org/10.1093/toxsci/kfy027
Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles.
Audureau É, Simon-Deckers A, Franco-Montoya ML, Annangi B, Kermanizadeh A, Boczkowski J and Lanone S 2018. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Scientific Reports. Vol 8 (Issue 1, Article: 8554). https://doi.org/10.1038/s41598-018-26988-z
Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice. Toxicological Sciences. Vol 158 (Issue 1), pp. 176 - 187. https://doi.org/10.1093/toxsci/kfx080
Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis
Kermanizadeh, A., Jantzen, K., Ward, M.B., Durhuus, J.A., Juel Rasmussen, L., Loft, S. and Møller, P. 2017. Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology. Vol 11 (Issue 2), pp. 184-200. https://doi.org/10.1080/17435390.2017.1279359
A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.
Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845
Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. Vol 3 (Issue 11, Article: e00458). https://doi.org/10.1016/j.heliyon.2017.e00458
Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials
Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35
On certain series expansions of the sine function: Catalan numbers and convergence
Larcombe, Peter J., O'Neill, Sam T. and Fennessey, Eric J. 2014. On certain series expansions of the sine function: Catalan numbers and convergence. Fibonacci Quarterly.
Nanotoxicology: Focus on nanomedicine
Johnston, H., Kermanizadeh, A. and Stone, V. Raj Bawa, Gerald F. Audette and Brian Reese (ed.) 2016. Nanotoxicology: Focus on nanomedicine. New York Routledge.
Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide
Christophersen, D.V., Jacobsen, N.R., Jensen, D.M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Voge, U., Wallin, H. and Møller, P. 2016. Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLos ONE. Vol 11 (Issue 8, Article: e0160731). https://doi.org/10.1371/journal.pone.0160731
Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles
Vranic, S., Gosens, I., Jacobsen, N.R., Jensen, K.A., Bokkers, B., Kermanizadeh, A., Stone, V., Baeza-Squiban, A., Cassee, F.R., Tran, L. and Boland, S. 2016. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Archives of toxicology. Vol 91 (Issue 1), pp. 353 - 363. https://doi.org/10.1007/s00204-016-1673-3
Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells
Kermanizadeh, A., Villadsen, K., Østrem, R.G., Jensen, K.J., Møller, P. and Loft, S. 2016. Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells. Basic and Clinical Pharmacology and Toxicology. Vol 120 (Issue 4), pp. 380 - 389. https://doi.org/10.1111/bcpt.12692
Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
Møller, P., Christophersen, D.V., Jacobsen, N.R., Skovmand, A., Gouveia, A.C.D., Andersen, M.H.G., Kermanizadeh, A., Jensen, D.M., Danielsen, P.H., Roursgaard, M., Jantzen, K. and Loft, S. 2016. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology. Vol 46 (Issue 5), pp. 437-476. https://doi.org/10.3109/10408444.2016.1149451
A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges
Kermanizadeh, A., Gosens, I., MacCalman, L., Johnston, H., Danielsen, P.H., Jacobsen, N.R., Lenz, A.-G., Fernandes, T., Schins, R.P.F., Cassee, F.R., Wallin, H., Kreyling, W., Stoeger, T., Loft, S., Møller, P., Tran, L. and Stone, V. 2016. A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health - Part B: Critical Reviews. Vol 19 (Issue 1), pp. 1-28. https://doi.org/10.1080/10937404.2015.1126210
An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine
Matthew S.P. Boyles, Leagh G. Powell, Ali Kermanizadeh, Helinor J. Johnston, Barbara Rothen-Rutishauser, Vicki Stone and Martin J.D. Clift 2016. An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. in: Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production Wiley Online Library. pp. 443-468
Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes.
Borghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P 2016. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes. Mutagenesis. Vol 32 (Issue 1), p. 173–180. https://doi.org/10.1093/mutage/gew036
Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats
Løhr, M., Folkmann, J.K., Sheykhzade, M., Jensen, L.J., Kermanizadeh, A., Loft, S. and Møller, P. 2015. Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLos ONE. Vol 10 (Issue 3, Article: e0118773). https://doi.org/10.1371/journal.pone.0118773
Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review
Kermanizadeh, A., Balharry, D., Wallin, H., Loft, S. and Møller, P. 2015. Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review. Critical Reviews in Toxicology. Vol 45 (Issue 10), pp. 837-872. https://doi.org/10.3109/10408444.2015.1058747
Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories
Jacobsen, N.R., Stoeger, T., van den Brule, S., Saber, A.T., Beyerle, A., Vietti, G., Mortensen, A., Szarek, J., Budtz, H.C., Kermanizadeh, A., Banerjee, A., Ercal, N., Vogel, U., Wallin, H. and Møller, P. 2015. Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories. Food and Chemical Toxicology. Vol 85 (Nov 2015), pp. 84 - 95. https://doi.org/10.1016/j.fct.2015.08.008
Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice
Gosens, I., Kermanizadeh, A., Jacobsen, N.R., Lenz, A.-G., Bokkers, B., De Jong, W.H., Krystek, P., Tran, L., Stone, V., Wallin, H., Stoeger, T. and Cassee, F.R. 2015. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLos ONE. Vol 10 (Issue 5, Article: 0126934). https://doi.org/10.1371/journal.pone.0126934
The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation
Nattrass, C., Horwell, C.J., Damby, D.E., Kermanizadeh, A., Brown, D.M. and Stone, V. 2015. The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation. Journal of Occupational Medicine and Toxicology. Vol 10 (Issue 1, Article: 23). https://doi.org/10.1186/s12995-015-0064-7
Nanotoxicology
Dominique Balharry, Eva Gubbins, Helinor Johnston, Kermanizadeh, A. and Vicki Stone 2015. Nanotoxicology. in: Nanoparticles in the Lung Boca Raton CRC Press.
A linear logic approach to the composition of RESTful web services
Zhao, X., Liu, E., Yu, H. and Clapworthy, G.J. 2015. A linear logic approach to the composition of RESTful web services. International Journal of Web Engineering and Technology. 10 (3), pp. 245-271. https://doi.org/10.1504/ijwet.2015.072348
The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review
Kermanizadeh, A., Chauché, C., Brown, D.M., Loft, S. and Møller, P. 2014. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 111 - 124. https://doi.org/10.1002/em.21926
Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells
Cao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P. 2014. Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells. International Journal of Toxicology. Vol 34 (Issue 1), pp. 67 - 76. https://doi.org/10.1177/1091581814560032
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Belade, E., Chrusciel, S., Armand, L., Simon-Deckers, A., Bussy, C., Caramelle, P., Gagliolo, J.-M., Boyer, L., Lanone, S., Pairon, J.-C., Kermanizadeh, A. and Boczkowski, J. 2014. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. Vol 89 (Issue 9), pp. 1543 - 1556. https://doi.org/10.1007/s00204-014-1324-5
Role of oxidative stress in carbon nanotube-generated health effects
Møller, P., Christophersen, D.V., Jensen, D.M., Kermanizadeh, A., Roursgaard, M., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Role of oxidative stress in carbon nanotube-generated health effects. Archives of toxicology. Vol 88 (Issue 11), pp. 1939 - 1964. https://doi.org/10.1007/s00204-014-1356-x
Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals
Møller, P., Jensen, D.M., Christophersen, D.V., Kermanizadeh, A., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Karottki, D.G., Roursgaard, M., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 97 - 110. https://doi.org/10.1002/em.21899
Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure
Møller, P., Hemmingsen, J.G., Jensen, D.M., Danielsen, P.H., Karottki, D.G., Jantzen, K., Roursgaard, M., Cao, Y., Kermanizadeh, A., Klingberg, H., Christophersen, D.V., Hersoug, L.-G. and Loft, S. 2014. Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure. Mutagenesis. Vol 30 (Issue 1), p. 67–83. https://doi.org/10.1093/mutage/geu035
Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
Kermanizadeh, A., Løhr, M., Roursgaard, M., Messner, S., Gunness, P., Kelm, J.M., Møller, P., Stone, V. and Loft, S. 2014. Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model. Particle and Fibre Toxicology. Vol 11 (Issue 1, Article: 56). https://doi.org/10.1186/s12989-014-0056-2
The role of Kupffer cells in the hepatic response to silver nanoparticles.
Kermanizadeh, A., Chauché, C., Balharry, D., Brown, D. M., Kanase, N., Boczkowski, J., Lanone, S. and Stone, V. 2013. The role of Kupffer cells in the hepatic response to silver nanoparticles. Nanotoxicology. 1 (1), pp. 149-154. https://doi.org/10.3109/17435390.2013.866284
Socio-semantic Integration of Educational Resources - the Case of the mEducator Project
Dietze, Stefan, Kaldoudi, Eleni, Dovrolis, Nikolas, Giordano, Daniela, Spampinato, Concetto, Hendrix, Maurice, Protopsaltis, Aristidis, Taibi, v and Yu, H. 2013. Socio-semantic Integration of Educational Resources - the Case of the mEducator Project. Journal of Universal Computer Science. 19 (11), pp. 1-27. https://doi.org/10.3217/jucs-019-11-1543
Interlinking educational resources and the web of data
Dietze, S., Sanchez‐Alonso, S., Ebner, H., Yu, H., Giordano, D., Marenzi, I. and Pereira Nunes, B. 2013. Interlinking educational resources and the web of data. Program. 47 (1). https://doi.org/10.1108/00330331211296312
Using Linked Data to Annotate and Search Educational Video Resources for Supporting Distance Learning
Yu, H., Pedrinaci, C., Dietze, S. and Domingue, J. 2012. Using Linked Data to Annotate and Search Educational Video Resources for Supporting Distance Learning. IEEE Transactions on Learning Technologies. 5 (2), pp. 130-142. https://doi.org/10.1109/tlt.2012.1
An automated approach to Semantic Web Services Mediation
Dietze, S., Gugliotta, A., Domingue, J., Yu, H. and Mrissa, M. 2010. An automated approach to Semantic Web Services Mediation. Service Oriented Computing and Applications. 4, p. 261–275. https://doi.org/10.1007/s11761-010-0070-7