Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.

Journal article


Kermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki 2022. Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology. https://doi.org/10.1080/17435390.2021.2020350
AuthorsKermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki
Abstract

With ever-increasing production and use of nanoparticles (NPs), there is a necessity to evaluate the probability of consequential adverse effects in individuals exposed to these particles. It is now understood that a proportion of NPs can translocate from primary sites of exposure to a range of secondary organs, with the liver, kidneys and spleen being some of the most important. In this study, we carried out a comprehensive toxicological profiling (inflammation, changes in serum biochemistry, oxidative stress, acute phase response and histopathology) of Ag NP induced adverse effects in the three organs of interest following acute exposure of the materials at identical doses via intravenous (IV), intratracheal (IT) instillation and oral administration. The data clearly demonstrated that bioaccumulation and toxicity of the particles were most significant following the IV route of exposure, followed by IT. However, oral exposure to the NPs did not result in any changes that could be interpreted as toxicity in any of the organs of interest within the confines of this investigation. The finding of this study clearly indicates the importance of the route of exposure in secondary organ hazard assessment for NPs. Finally, we identify Connexin 32 (Cx32) as a novel biomarker of NP-mediated hepatic damage which is quantifiable both (in vitro) and in vivo following exposure of physiologically relevant doses.

KeywordsAg NPs; Connexin 32; Liver; acute-phase response; different routes of exposure; inflammation; kidneys; oxidative stress; pathology; spleen
Year2022
JournalNanotoxicology
PublisherTaylor & Francis
ISSN1743-5404
Digital Object Identifier (DOI)https://doi.org/10.1080/17435390.2021.2020350
Web address (URL)http://hdl.handle.net/10545/626345
http://creativecommons.org/publicdomain/zero/1.0/
hdl:10545/626345
Publication dates11 Jan 2022
Publication process dates
Deposited07 Mar 2022, 12:33
Accepted15 Dec 2021
Rights

CC0 1.0 Universal

Place of publicationEngland
ContributorsUniversity of Derby, National Research Centre for the Working Environment, Copenhagen, Denmark and Heriot Watt University, Edinburgh
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