A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

Journal article

Ali Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller 2020. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. Vol 4 (Issue 2, Article: 2000186). https://doi.org/10.1002/adtp.202000186
AuthorsAli Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller
Abstract

The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.

Keywordscancer; inappropriate test models; nanomedicines; oncological nanomedicines; targeting and therapy
Year2020
JournalAdvanced Therapeutics
Journal citationVol 4 (Issue 2, Article: 2000186)
PublisherJohn Wiley & Sons Ltd
ISSN23663987
Digital Object Identifier (DOI)https://doi.org/10.1002/adtp.202000186
Web address (URL)https://doi.org/10.1002/adtp.202000186
Output statusPublished
Publication dates09 Feb 2021
Online09 Nov 2020
Publication process dates
Deposited12 Jun 2023
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