Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?

Journal article

Kermanizadeh, A. 2020. Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition. Vol 9 (Issue 1). https://doi.org/10.21037/hbsn.2019.09.09
AuthorsKermanizadeh, A.
Abstract

To date traditional toxicity testing has relied heavily on in-life animal studies that are expensive and restrictive with regards to very important ethical implications. In addition, these studies often yield data that are not relevant to human exposures or biological responses due to intra-species variations, necessitating the requirement for further testing or candidate (drug) abandonment in late development stages. There is increasing global pressure from regulatory agencies, the general public, and the scientific community to develop in vitro alternatives for toxicity testing that can be utilized for mechanistic dose response hazard identification prior to embarking on small well designed and absolutely necessary in vivo studies.

KeywordsToxicity; Hepatic cell test; Next generation
Year2020
JournalHepatobiliary Surgery and Nutrition
Journal citationVol 9 (Issue 1)
PublisherHBSN
ISSN2304-3881
2304-389X
Digital Object Identifier (DOI)https://doi.org/10.21037/hbsn.2019.09.09
Web address (URL)http://dx.doi.org/10.21037/hbsn.2019.09.09
Output statusPublished
Publication dates01 Feb 2020
Publication process dates
Accepted09 Sep 2019
Deposited12 Jun 2023
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