Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes.

Journal article

Borghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P 2016. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes. Mutagenesis. Vol 32 (Issue 1), p. 173–180. https://doi.org/10.1093/mutage/gew036
AuthorsBorghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P
Abstract

One type of carbon nanotubes (CNTs) (MWCNT-7, from Mitsui) has been classified as probably carcinogenic to humans, however insufficient data does not warrant the same classification for other types of CNTs. Experimental data indicate that CNT exposure can result in oxidative stress and DNA damage in cultured cells, whereas these materials appear to induce low or no mutagenicity. Therefore, the present study aimed to investigate whether in vitro exposure of cultured airway epithelial cells (A549) to multi-walled CNTs (MWCNTs) could increase the DNA repair activity of oxidatively damaged DNA and drive the cells toward replicative senescence, assessed by attrition of telomeres. To investigate this, H2O2 and KBrO3 were used to induce DNA damage in the cells and the effect of pre-exposure to MWCNT tested for a change in repair activity inside the cells or in the extract of treated cells. The effect of MWCNT exposure on telomere length was investigated for concentration and time response. We report a significantly increased repair activity in A549 cells exposed to MWCNTs compared to non-exposed cells, suggesting that DNA repair activity may be influenced by exposure to MWCNTs. The telomere length was decreased at times longer than 24h, but this decrease was not concentration dependent. The results suggest that the seemingly low mutagenicity of CNTs in cultured cells may be associated with an increased DNA repair activity and a replicative senescence, which may counteract the manifestation of DNA lesions to mutations.

Keywords lung; dna; dna damage; dna repair; hydrogen peroxide; telomere; epithelial cells; carbon nanotubes; a549 cells
Year2016
JournalMutagenesis
Journal citationVol 32 (Issue 1), p. 173–180
PublisherOxford Academic
ISSN1464-3804
0267-8357
Digital Object Identifier (DOI)https://doi.org/10.1093/mutage/gew036
Web address (URL)http://europepmc.org/abstract/med/27530331
https://www.scopus.com/record/display.uri?eid=2-s2.0-85021861700&origin=resultslist&sort=plf-f&src=s&st1=Repair+activity+of+oxidatively+damaged+DNA+and+telomere+length+in+human+lung+epithelial+cells+after+exposure+to+multi-walled+carbon+nanotubes&sid=3dab1d3a054e310fbc809b7740e70233&sot=b&sdt=b&sl=156&s=TITLE-ABS-KEY%28Repair+activity+of+oxidatively+damaged+DNA+and+telomere+length+in+human+lung+epithelial+cells+after+exposure+to+multi-walled+carbon+nanotubes%29&relpos=0&citeCnt=21&searchTerm=
Output statusPublished
Publication dates01 Jan 2017
Online16 Aug 2016
Publication process dates
Deposited12 Jun 2023
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