A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.

Journal article

Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845
AuthorsKermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S
Abstract

To date, the use and translation of nanomedicine from the laboratory to the clinic has been relatively slow. Among other issues, one of the reasons for this tardiness is the lack of the availability of quick and reliable toxicity tools for the screening of nanomaterials (NMs). In this investigation, we apply a flow cytometry-based method for the detection of nanomaterial-induced oxidative stress by measurement of reactive oxygen species production in specific leukocyte subpopulations in human whole blood. The screening of a panel of relevant nanomedical-associated materials (liposomes, silica, iron oxide and functionalized single-walled carbon nanotubes) demonstrated that only the carbon nanotubes induced oxidative stress in human circulating leukocytes. In summary, we apply and corroborate a flow cytometry-based method for the simple and effective measurement of NM-induced oxidative stress in human blood subpopulations after realistic and relevant exposure scenarios which is extremely useful in future toxicological applications.

KeywordsNanomedicine; Toxicological applications; Screenings
Year2017
JournalBasic & Clinical Pharmacology & Toxicology,
Journal citationVol 122 (Issue 1), pp. 149 - 156
PublisherWiley Online Library
ISSN1742-7843
1742-7835
Digital Object Identifier (DOI)https://doi.org/10.1111/bcpt.12845
Web address (URL)http://europepmc.org/abstract/med/28691406
Output statusPublished
Publication dates
Online10 Jul 2017
06 Aug 2017
OnlineJan 2018
Publication process dates
Deposited12 Jun 2023
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