Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells

Journal article

Cao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P. 2014. Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells. International Journal of Toxicology. Vol 34 (Issue 1), pp. 67 - 76. https://doi.org/10.1177/1091581814560032
AuthorsCao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P.
Abstract

Fatty acids exposure may increase sensitivity of intestinal epithelial cells to cytotoxic effects of zinc oxide (ZnO) nanoparticles (NPs). This study evaluated the synergistic effects of ZnO NPs and palmitic acid (PA) or free fatty acids (FFAs) mixture (oleic/PA 2:1) on toxicity to human colon epithelial (Caco-2) cells. The ZnO NPs exposure concentration dependently induced cytotoxicity to Caco-2 cells showing as reduced proliferation and activity measured by 3 different assays. PA exposure induced cytotoxicity, and coexposure to ZnO NPs and PA showed the largest cytotoxic effects. The presence of FFAs mixture did not affect the ZnO NPs-induced cytotoxicity. Filtration of freshly prepared suspension of NPs through a 0.45-µm pore size membrane significantly reduced the cytotoxicity, indicating a role of concentration or size of particles in cytotoxic effects. The ZnO NPs and PA coexposure induced production of mitochondrial reactive oxygen species (mROS) but not intracellular ROS production, whereas FFAs mixture exposure did not induce mROS and inhibited intracellular ROS. Both ZnO NPs and fatty acids (PA and FFAs mixture) promoted lysosomal destabilization, which was not correlated with cytotoxicity. These results indicated that PA can enhance ZnO NPs-induced cytotoxicity probably by the augmentation of mROS production, whereas FFAs mixture did not affect ROS production. Synergistic effects between ZnO NPs and fatty acids may be important when considering NPs toxicity via oral exposure.

KeywordsCaco-2 cells; fatty acid; lysosomal destabilization; mitochondrial ROS; zinc oxide nanoparticle
Year2014
JournalInternational Journal of Toxicology
Journal citationVol 34 (Issue 1), pp. 67 - 76
PublisherSAGE Publications
ISSN10915818
1092-874X
Digital Object Identifier (DOI)https://doi.org/10.1177/1091581814560032
Web address (URL)http://www.scopus.com/inward/record.url?eid=2-s2.0-84923516564&partnerID=MN8TOARS
Output statusPublished
Publication dates
Online23 Nov 2014
Jan 2015
Publication process dates
Accepted2014
Deposited14 Jun 2023
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https://repository.derby.ac.uk/item/9z43w/synergistic-effects-of-zinc-oxide-nanoparticles-and-fatty-acids-on-toxicity-to-caco-2-cells

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