Ali Kermanizadeh
| Name | Ali Kermanizadeh |
|---|---|
| Job title | Senior Lecturer in Clinical Biochemistry and Toxicology |
| Research institute | College of Science and Engineering |
| ORCID | https://orcid.org/0000-0002-2989-9078 |
Research outputs
Drug induced liver injury - a 2023 update.
Allison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A. 2023. Drug induced liver injury - a 2023 update. Journal of Toxicology and Environmental Health, Part B. 26 (8), pp. 1-26. https://doi.org/10.1080/10937404.2023.2261848AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research
Yu, H., O'Neill, S. and Kermanizadeh, A. 2023. AIMS: An Automatic Semantic Machine Learning Microservice Framework to Support Biomedical and Bioengineering Research. Bioengineering. 10 (10), pp. 1-18. https://doi.org/10.3390/bioengineering10101134Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Llewellyn, S. V., Kermanizadeh, A., Ude, V., Jacobsen, N. R., Conway, G. E., Shah, U. K., Niemeijer, M., van de Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G. J. S. and Doak, S. H. 2022. Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in vitro. 85 (105473), pp. 1-9. https://doi.org/10.1016/j.tiv.2022.105473The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment.
Kermanizadeh, A. 2022. The application of existing genotoxicity methodologies for grouping of nanomaterials: Towards an integrated approach to testing and assessment. Particle and Fibre Toxicology. 19 (32). https://doi.org/10.1186/s12989-022-00476-9Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.
Kermanizadeh, Ali, Jacobsen, Nicklas R, Mroczko, Agnieszka, Brown, David and Stone, Vicki 2022. Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology. 15 (10). https://doi.org/10.1080/17435390.2021.2020350Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH.
Kermanizadeh, Ali, Valli, Jessica, Sanchez, Katarzyna, Hutter, Simon, Pawlowska, Agnieszka, Whyte, Graeme, Moritz, Wolfgang and Stone, Vicki 2021. Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. Archives of toxicology. 96 (1), pp. 287-303. https://doi.org/10.1007/s00204-021-03181-2A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Ali Kermanizadeh, Nicklas Raun Jacobsen, Fiona Murphy, Leagh Powell, Lee Parry, Haiyuan Zhang and Peter Møller 2020. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. Vol 4 (Issue 2, Article: 2000186). https://doi.org/10.1002/adtp.202000186A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs
Ali Kermanizadeh, Leagh G Powell and Vicki Stone 2020. A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs. Journal of Toxicology and Environmental Health, Part B. Vol 23 (Issue 4), pp. 137-176. https://doi.org/10.1080/10937404.2020.1751756Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?
Kermanizadeh, A. 2020. Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition. Vol 9 (Issue 1). https://doi.org/10.21037/hbsn.2019.09.09Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing?
Kermanizadeh, A. and Moritz, W. 2020. Next generation in vitro primary hepatic cell test systems - their suitability as an alternative to in vivo testing? Hepatobiliary Surgery and Nutrition . 9 (1), pp. 103-105. https://doi.org/10.21037/hbsn.2019.09.09Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz and Vicki Stone 2019. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and Fibre Toxicology. Vol 16 (Issue 1), p. Article: 42. https://doi.org/10.1186/s12989-019-0326-0The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials
Ali Kermanizadeh, David M. Brown and Vicki Stone 2019. The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials. PLos ONE. Vol 14 (Issue 8). https://doi.org/10.1371/journal.pone.0220974Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencatti, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas 2019. Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications. https://doi.org/10.1101/647347The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
Kermanizadeh, A., Brown, D. M., Moritz, W. and Stone, V. 2019. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. Scientific Reports. 9 (7295), pp. 1-9. https://doi.org/10.1038/s41598-019-43870-8Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles.
Audureau É, Simon-Deckers A, Franco-Montoya ML, Annangi B, Kermanizadeh A, Boczkowski J and Lanone S 2018. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Scientific Reports. Vol 8 (Issue 1, Article: 8554). https://doi.org/10.1038/s41598-018-26988-zInhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects.
Jantzen K, Jensen A, Kermanizadeh A, Elholm G, Sigsgaard T, Møller P, Roursgaard M and Loft S 2018. Inhalation of House Dust and Ozone Alters Systemic Levels of Endothelial Progenitor Cells, Oxidative Stress, and Inflammation in Elderly Subjects. Toxicological sciences : an official journal of the Society of Toxicology. Vol 163 (Issue 2), p. 353–363. https://doi.org/10.1093/toxsci/kfy027Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
Andersen MHG, Saber AT, Pedersen JE, Pedersen PB, Clausen PA, Løhr M, Kermanizadeh A, Loft S, Ebbehøj NE, Hansen ÅM, Kalevi Koponen I, Nørskov EC and Møller P 2018. Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift. Environmental and molecular mutagenesis. Vol 59 (Issue 6), pp. 539-548. https://doi.org/10.1002/em.22193Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. Vol 3 (Issue 11, Article: e00458). https://doi.org/10.1016/j.heliyon.2017.e00458Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises.
Andersen MHG, Saber AT, Clausen PA, Pedersen JE, Løhr M, Kermanizadeh A, Loft S, Ebbehøj N, Hansen ÅM, Pedersen PB, Koponen IK, Nørskov EC, Møller P and Vogel U 2018. Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. Mutagenesis. Vol 33 (Issue 1), pp. 105 - 115. https://doi.org/10.1093/mutage/gex021Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials
Kermanizadeh, A., Kim Jantzen, Astrid Skovmand, Ana C. D. Gouveia, Nicklas R. Jacobsen, Vicki Stone and Martin J. D. Clift 2017. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials. in: Peter Grunwald (ed.) Biocatalysis and Nanotechnology New York Taylor & Francis. pp. 35A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood.
Kermanizadeh A, Jantzen K, Brown DM, Møller P and Loft S 2017. A Flow Cytometry-based Method for the Screening of Nanomaterial-induced Reactive Oxygen Species Production in Leukocyte Sub-Populations in Whole Blood. Basic & Clinical Pharmacology & Toxicology,. Vol 122 (Issue 1), pp. 149 - 156. https://doi.org/10.1111/bcpt.12845Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice.
Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S and Møller P 2017. Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice. Toxicological Sciences. Vol 158 (Issue 1), pp. 176 - 187. https://doi.org/10.1093/toxsci/kfx080Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis
Kermanizadeh, A., Jantzen, K., Ward, M.B., Durhuus, J.A., Juel Rasmussen, L., Loft, S. and Møller, P. 2017. Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology. Vol 11 (Issue 2), pp. 184-200. https://doi.org/10.1080/17435390.2017.1279359An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine
Matthew S.P. Boyles, Leagh G. Powell, Ali Kermanizadeh, Helinor J. Johnston, Barbara Rothen-Rutishauser, Vicki Stone and Martin J.D. Clift 2016. An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. in: Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production Wiley Online Library. pp. 443-468Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells
Kermanizadeh, A., Villadsen, K., Østrem, R.G., Jensen, K.J., Møller, P. and Loft, S. 2016. Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells. Basic and Clinical Pharmacology and Toxicology. Vol 120 (Issue 4), pp. 380 - 389. https://doi.org/10.1111/bcpt.12692Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide
Christophersen, D.V., Jacobsen, N.R., Jensen, D.M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Voge, U., Wallin, H. and Møller, P. 2016. Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLos ONE. Vol 11 (Issue 8, Article: e0160731). https://doi.org/10.1371/journal.pone.0160731Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes.
Borghini A, Roursgaard M, Andreassi MG, Kermanizadeh A and Møller P 2016. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes. Mutagenesis. Vol 32 (Issue 1), p. 173–180. https://doi.org/10.1093/mutage/gew036Nanotoxicology: Focus on nanomedicine
Johnston, H., Kermanizadeh, A. and Stone, V. Raj Bawa, Gerald F. Audette and Brian Reese (ed.) 2016. Nanotoxicology: Focus on nanomedicine. New York Routledge.Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
Møller, P., Christophersen, D.V., Jacobsen, N.R., Skovmand, A., Gouveia, A.C.D., Andersen, M.H.G., Kermanizadeh, A., Jensen, D.M., Danielsen, P.H., Roursgaard, M., Jantzen, K. and Loft, S. 2016. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology. Vol 46 (Issue 5), pp. 437-476. https://doi.org/10.3109/10408444.2016.1149451A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges
Kermanizadeh, A., Gosens, I., MacCalman, L., Johnston, H., Danielsen, P.H., Jacobsen, N.R., Lenz, A.-G., Fernandes, T., Schins, R.P.F., Cassee, F.R., Wallin, H., Kreyling, W., Stoeger, T., Loft, S., Møller, P., Tran, L. and Stone, V. 2016. A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health - ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health - Part B: Critical Reviews. Vol 19 (Issue 1), pp. 1-28. https://doi.org/10.1080/10937404.2015.1126210Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles
Vranic, S., Gosens, I., Jacobsen, N.R., Jensen, K.A., Bokkers, B., Kermanizadeh, A., Stone, V., Baeza-Squiban, A., Cassee, F.R., Tran, L. and Boland, S. 2016. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Archives of toxicology. Vol 91 (Issue 1), pp. 353 - 363. https://doi.org/10.1007/s00204-016-1673-3Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories
Jacobsen, N.R., Stoeger, T., van den Brule, S., Saber, A.T., Beyerle, A., Vietti, G., Mortensen, A., Szarek, J., Budtz, H.C., Kermanizadeh, A., Banerjee, A., Ercal, N., Vogel, U., Wallin, H. and Møller, P. 2015. Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories. Food and Chemical Toxicology. Vol 85 (Nov 2015), pp. 84 - 95. https://doi.org/10.1016/j.fct.2015.08.008The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation
Nattrass, C., Horwell, C.J., Damby, D.E., Kermanizadeh, A., Brown, D.M. and Stone, V. 2015. The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation. Journal of Occupational Medicine and Toxicology. Vol 10 (Issue 1, Article: 23). https://doi.org/10.1186/s12995-015-0064-7Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review
Kermanizadeh, A., Balharry, D., Wallin, H., Loft, S. and Møller, P. 2015. Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-A review. Critical Reviews in Toxicology. Vol 45 (Issue 10), pp. 837-872. https://doi.org/10.3109/10408444.2015.1058747Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice
Gosens, I., Kermanizadeh, A., Jacobsen, N.R., Lenz, A.-G., Bokkers, B., De Jong, W.H., Krystek, P., Tran, L., Stone, V., Wallin, H., Stoeger, T. and Cassee, F.R. 2015. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLos ONE. Vol 10 (Issue 5, Article: 0126934). https://doi.org/10.1371/journal.pone.0126934Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats
Løhr, M., Folkmann, J.K., Sheykhzade, M., Jensen, L.J., Kermanizadeh, A., Loft, S. and Møller, P. 2015. Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLos ONE. Vol 10 (Issue 3, Article: e0118773). https://doi.org/10.1371/journal.pone.0118773Nanotoxicology
Dominique Balharry, Eva Gubbins, Helinor Johnston, Kermanizadeh, A. and Vicki Stone 2015. Nanotoxicology. in: Nanoparticles in the Lung Boca Raton CRC Press.The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review
Kermanizadeh, A., Chauché, C., Brown, D.M., Loft, S. and Møller, P. 2014. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 111 - 124. https://doi.org/10.1002/em.21926Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells
Cao, Y., Roursgaard, M., Kermanizadeh, A., Loft, S. and Møller, P. 2014. Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells. International Journal of Toxicology. Vol 34 (Issue 1), pp. 67 - 76. https://doi.org/10.1177/1091581814560032Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure
Møller, P., Hemmingsen, J.G., Jensen, D.M., Danielsen, P.H., Karottki, D.G., Jantzen, K., Roursgaard, M., Cao, Y., Kermanizadeh, A., Klingberg, H., Christophersen, D.V., Hersoug, L.-G. and Loft, S. 2014. Applications of the comet assay in particle toxicology: Air pollution and engineered nanomaterials exposure. Mutagenesis. Vol 30 (Issue 1), p. 67–83. https://doi.org/10.1093/mutage/geu035Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
Kermanizadeh, A., Løhr, M., Roursgaard, M., Messner, S., Gunness, P., Kelm, J.M., Møller, P., Stone, V. and Loft, S. 2014. Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model. Particle and Fibre Toxicology. Vol 11 (Issue 1, Article: 56). https://doi.org/10.1186/s12989-014-0056-2Role of oxidative stress in carbon nanotube-generated health effects
Møller, P., Christophersen, D.V., Jensen, D.M., Kermanizadeh, A., Roursgaard, M., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Role of oxidative stress in carbon nanotube-generated health effects. Archives of toxicology. Vol 88 (Issue 11), pp. 1939 - 1964. https://doi.org/10.1007/s00204-014-1356-xMeasurement of oxidative damage to DNA in nanomaterial exposed cells and animals
Møller, P., Jensen, D.M., Christophersen, D.V., Kermanizadeh, A., Jacobsen, N.R., Hemmingsen, J.G., Danielsen, P.H., Karottki, D.G., Roursgaard, M., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L.-G. and Loft, S. 2014. Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environmental and Molecular Mutagenesis. Vol 56 (Issue 2), pp. 97 - 110. https://doi.org/10.1002/em.21899The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Belade, E., Chrusciel, S., Armand, L., Simon-Deckers, A., Bussy, C., Caramelle, P., Gagliolo, J.-M., Boyer, L., Lanone, S., Pairon, J.-C., Kermanizadeh, A. and Boczkowski, J. 2014. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. Vol 89 (Issue 9), pp. 1543 - 1556. https://doi.org/10.1007/s00204-014-1324-5The role of Kupffer cells in the hepatic response to silver nanoparticles.
Kermanizadeh, A., Chauché, C., Balharry, D., Brown, D. M., Kanase, N., Boczkowski, J., Lanone, S. and Stone, V. 2013. The role of Kupffer cells in the hepatic response to silver nanoparticles. Nanotoxicology. 1 (1), pp. 149-154. https://doi.org/10.3109/17435390.2013.866284598
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