Advancing the global public health agenda for NAFLD: a consensus statement

Journal article


Shawa, I. and Consortium 2021. Advancing the global public health agenda for NAFLD: a consensus statement. Nature Reviews. Gastroenterology and Hepatology. 19 (1), pp. 60-78. https://doi.org/10.1038/s41575-021-00523-4
AuthorsShawa, I. and Consortium
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.

KeywordsNon-alcoholic fatty liver disease; public health response ; epidemiology
Year2021
JournalNature Reviews. Gastroenterology and Hepatology
Journal citation19 (1), pp. 60-78
PublisherSpringer Nature Limited
ISSN1759-5053
Digital Object Identifier (DOI)https://doi.org/10.1038/s41575-021-00523-4
Web address (URL)https://www.nature.com/articles/s41575-021-00523-4
https://pubmed.ncbi.nlm.nih.gov/34707258/
Output statusPublished
Publication dates
Online27 Oct 2021
Publication process dates
Accepted02 Sep 2021
Deposited06 Jun 2023
Permalink -

https://repository.derby.ac.uk/item/9z0qq/advancing-the-global-public-health-agenda-for-nafld-a-consensus-statement

  • 13
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Drug induced liver injury - a 2023 update.
Allison, R., Guraka, A., Shawa, I., Tripathi, G., Moritz, W. and Kermanizadeh, A. 2023. Drug induced liver injury - a 2023 update. Journal of Toxicology and Environmental Health, Part B. 26 (8), pp. 1-26. https://doi.org/10.1080/10937404.2023.2261848
Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019
Mhango, C, Mandolo, J.J, Chinyama, E, Wachepa, R, Kanjerwa, O, Malamba-Banda, C, Matambo, P.B, Barnes, K.G, Chaguza, C, Shawa, I., Nyaga, M.M, Hungerford, D, Parashar, U.D, Pitzer, V.E, Kamng’ona, A.W, Iturriza-Gomara, M, Cunliffe, N.A and Jere, K.C 2022. Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019. The Journal of Infectious Diseases. 225 (12), pp. 2127 - 2136. https://doi.org/10.1093/infdis/jiaa616
Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi
Stockdale, A.J, Meiring, J.E, Shawa, I., Thindwa, D, Silungwe, N.M, Mbewe, M, Kachala, R, Kreuels, B, Patel, P, Patel, P, Henrion, M.Y.R, Bar-Zeev, N, Swarthout, T.D, Heyderman, R.S, Gordon, S.B, Geretti, A.M and Gordon, M.A 2022. Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi . The Journal of Infectious Diseases. 226 (5), p. 871–880. https://doi.org/10.1093/infdis/jiab562
A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission
Stockdale, A.J, Kreuels, B, Shawa, I.T, Meiring, J.E, Thindwa, D, Silungwe, N.M, Chetcuti, K, Joekes, E, Mbewe, M, Mbale, B, Patel, P, Kachala, R, Patel, P.D, Malewa, J, Finch, P, Davis, C, Shah, R, Tong, L, Filipe, A.D.S, Thomson, E.C, Geretti, A.M and Gordon, M.A 2022. A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission. Journal of Viral Hepatitis. 29 (4), p. 252–262. https://doi.org/10.1111/jvh.13646
Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis
Shawa, I.T, Sheridan, D.A, Shawa, I.T, Thomas, E.L, Felmlee, D.J, Bridge, S.H, Neely, D, Cobbold, J.F, Holmes, E, Bassendine, M.F and Taylor-Robinson, S.D 2022. Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis. Scientific Reports . 12 (5562). https://doi.org/10.1038/s41598-022-09588-w
Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines
Benedicto-Matambo, P, Bines, J.E, Malamba-Banda, Chikondi, Shawa, I., Barnes, K, Kamng'ona, A.W, Hungerford, D, Jambo, K.C, Iturriza-Gomara, M, Cunliffe, N.A, Flanagan, K.L and Jere, K.C 2022. Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines. Vaccines. 10 (3), p. 418. https://doi.org/10.3390/vaccines10030418
The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?
Shawa, I. and Consortium 2021. The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge? Journal of Hepatology. 76 (4), pp. 771-780. https://doi.org/DOI:10.1016/j.jhep.2021.10.025
Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi
Mandolo, J.J, Henrion, M.Y.R, Mhango, C, Chinyama, E, Wachepa, R, Kanjerwa, O, Malamba-Banda,C, Shawa, I., Hungerford, D, Kamng’ona, A.W, Iturriza-Gomara, M, Cunliffe, N.A and Jere, K.C 2021. Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi. Viruses. 13 (12). https://doi.org/10.3390/v13122491
Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi
Stockdale, A.J, Silungwe, N.M, Shawa, I, Kreuels, B, Gordon, M.A and Geretti, A.M 2021. Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi. BMC Infectious Diseases. 21, p. 487. https://doi.org/10.1186/s12879-021-06134-3