Gyan Tripathi


NameGyan Tripathi
Job titleHead of Human Sciences Research Centre
Research instituteCollege of Science and Engineering

Research outputs

Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines

Krishnaswamy, S, Bukhari, I, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2018. Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines. Gene. https://doi.org/10.1016/j.gene.2018.09.027

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro

Pushpakom, S.P, Adaikalakoteswari, A, Owen, A, Back, D.J, Tripathi, G, Kumar, S, McTernan, P and Pirmohamed, M 2018. Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. Diabetes and Vascular Disease Research. https://doi.org/10.1177/1479164118757924

Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids

Jackisch, L, Kumsaiyai, W, Moore, J.D, Al-Daghri, N, Kyrou, I, Barber, T.M, Randeva, H, Kumar, S, Tripathi, G and McTernan, P.G 2018. Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia. https://doi.org/10.1007/s00125-018-4558-6

Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing

Krishnaswamy, S, Mohammed, A.K, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2017. Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing. BMC Cancer. https://doi.org/10.1186/s12885-017-3747-x

Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients

Al-Daghri, N.M, Mohammed, A.K, Al-Attas, O.S, Ansari, M.G.A, Wani, K, Hussain, S.D, Sabico, S, Tripathi, G and Alokail, M.S 2017. Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients. Scientific Reports. https://doi.org/10.1038/s41598-017-08621-7

Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery.

de la Escalera, L.M, Kyrou, I, Vrbikova, J, Hainer, V, Sramkova, P, Fried, M, Piya, M.K, Kumar, S, Tripathi, G and McTernan, P.G 2017. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine. https://doi.org/10.1186/s12916-017-0797-5

Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects

Al-Daghri, N.M, Rahman, S, Sabico, S, Yakout, S, Wani, K, Al-Attas, O.S, Saravanan, P, Tripathi, G, McTernan, P.G and Alokail, M.S 2016. Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients. https://doi.org/10.3390/nu8090460

Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes.

Hu, J, Kyrou, I, Tan, B.K, Dimitriadis, G.K, Ramanjaneya, M, Tripathi, G, Patel, V, James, S, Kawan, M, Chen, J and Randeva, H.S 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology. https://doi.org/10.1210/en.2015-1944

Surface charge visualization at viable living cells

Perry, D, Paulose Nadappuram, B, Momotenko, D, Voyias, P.D, Page, A, Tripathi, G, Frenguelli, B.G and Unwin, P.R 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b13153

Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15–19 in lung cancer

Krishnaswamy, S, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2015. Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15–19 in lung cancer. Lung Cancer. https://doi.org/10.1016/j.lungcan.2015.12.002

Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer

Krishnaswamy, S, Mohammed, A.K, Amer, O.E, Tripathi, G, Alokail, M.S and Al-Daghri, N.M 2015. Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer. International Journal of Clinical and Experimental Medicine.

Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases.

Al-Disi, D, A-Daghri, N, Khan, N, Alfadda, A, Sallam, R, Alsaif, M, Sabico, S, Tripathi, G and McTernan, P 2015. Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases. Nutrients. https://doi.org/10.3390/nu7085290

PWE-254 Is the macroscopically normal mucosa (MNM) around colorectal cancer really ‘normal’?

Patel, A, Fang, Y, Moore, J, Williams, N, Tripathi, G and Arasaradnam, R 2015. PWE-254 Is the macroscopically normal mucosa (MNM) around colorectal cancer really ‘normal’? Gut. https://doi.org/10.1136/gutjnl-2015-309861.700

Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2

Al‐Daghri, N.M, Alokail, M.S, Rahman, S, Amer, O.E, Al‐Attas, O.S, Alfawaz, H, Tripathi, G, Sabico, S., Chrousos, G.P, McTernan, P.G and Piya, M.K 2015. Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. European Journal of Clinical Investigation. https://doi.org/10.1111/eci.12468

Field cancerisation in colorectal cancer: A new frontier or pastures past?

Patel, A, Tripathi, G, Gopalakrishnan, K, Williams, N and Arasaradnam, R.P 2015. Field cancerisation in colorectal cancer: A new frontier or pastures past? World Journal of Gastroenterology. https://doi.org/10.3748/wjg.v21.i13.3763

Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK

Adaikalakoteswari, A, Vatish, M, Lawson, A, Wood, C, Sivakumar, K, McTernan, P, Webster, C, Anderson, N, Yajnik, C, Tripathi, G and Saravanan, P 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients. https://doi.org/10.3390/nu7042401

Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks

Finer, S, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks. Norwich Research ParK.

Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly.

Reddy, N.L, Peng, C, Carreira, M.C, Halder, L, Hattersley, J, Piya, M.K, Tripathi, G, Randeva, H.S, Casanueva, F.F, McTernan, P.G and Kumar, S 2014. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Cinical Endocrinology. https://doi.org/10.1111/cen.12652

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.

Adaikalakoteswari, A, Jayashri, R, Sukumar, N, Venkataraman, H, Pradeepa, R, Gokulakrishnan, K, Anjana, R.M, McTernan, P.G, Tripathi, G, Patel, V and Kumar, S. 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-014-0129-4

Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3

Adaikalakoteswari, A, Finer, S, Voyias, P.D, McCarthy, M, Vatish, M, Moore, J, Smart-Halajko, M, Bawazeer, N, Al-Daghri, N.M, McTernan, P.G, Hitman, G.A, Saravanan, P and Tripathi, G 2014. Methyl donor deficiency due to low vitamin b12 impairs insulin signalling in human adipocytes by down regulating AKT pathway via PTEN and TRB3. American Diabetes Association.

PWE-001 field cancerisation theory in colorectal cancer (crc): what role do fibroblast growth factors have?

Patel, A, Williams, N, Nwokolo, C, Tripathi, G and Arasaradnam, R 2014. PWE-001 field cancerisation theory in colorectal cancer (crc): what role do fibroblast growth factors have? Gut. https://doi.org/10.1136/gutjnl-2014-307263.261

Maternal inheritance of circulating irisin in humans.

Al-Daghri, N.M, Al-Attas, O.S, Alokail, M.S, Alkharfy, K.M, Yousef, M, Vinodson, B, Amer, O.E, Alnaami, A.M, Sabico, S, Tripathi, G and Piya, M.K. 2014. Maternal inheritance of circulating irisin in humans. Clincal Science. https://doi.org/10.1042/CS20130426

Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration

Voyias, P, Antonysunil, A, Kumasaiyai, W, Kyrou, I, Vrbikova, J, Hainer, V, Fried, M, Sramkova, P, Saravanan, P, Kumar, S, McTernan, P and Tripathi, G 2014. Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration. bioscientifica. https://doi.org/10.1530/endoabs.34.P269

A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention

Al-Disi, D, Al-Daghri, N, Khan, N, Alsaif, M, Alfadda, A, Sabico, S, Tripathi, G and McTernan, P 2014. A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention. bioscientifica. https://doi.org/10.1530/endoabs.34.P223

Elevated cord leptin from low B12 mothers predicts birth weight

Antonysunil, A, Vatish, M, Lawson, A, Wood, C, Sivakumar, K, Webster, C, Anderson, N, McTernan, P, Tripathi, G and Saravanan, P 2014. Elevated cord leptin from low B12 mothers predicts birth weight. bioscientifica. https://doi.org/10.1530/endoabs.34.P262

Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects

Piya, M, Reddy, N, Campbell, A, Hattersley, J, Halder, L, Tripathi, G, Tahrani, A, Kumar, S, Barber, T and McTernan, P 2014. Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects. bioscientifica. https://doi.org/10.1530/endoabs.34.P226

Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells

Murphy, A, Jackisch, L., Azharian, S, Aladel, A, Barker, G, Tripathi, G, Chappell, M and McTernan, P 2014. Freeze dried broccoli extract relieves ER stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells. bioscientifica. https://doi.org/10.1530/endoabs.44.P191

Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss

Kumsaiyai, W, Al-Daghri, N, Kyrou, I, Vrbikova, J, Hainer, V, Fried, M, Sramkova, P, Barber, T, S Kumar, Tripathi, G and McTernan, P 2014. Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss. bioscientifica. https://doi.org/10.1530/endoabs.34.P238

Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes

Jackisch, L, Murphy, A, Al-Daghri, N, McTernan, P, Randeva, H and Tripathi, G 2014. Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes. bioscientifica. https://doi.org/10.1530/endoabs.44.P193

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

Piya, Milan K, Harte, A. L, Sivakumar, K, Tripathi, G, Voyias, P. D, James, S, Sabico, S, Al-Daghri, N, M, Saravanan, P, Barber, T. M, Kumar, S, Vatish, M and McTernan, P. G 2014. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. American Journal of Physiology Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00308.2013

Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation.

Reddy, N.L, Jones, T.A, Wayte, S.C, Adesanya, O, Sankar, S, Yeo, Y.C, Tripathi, G, McTernan, P.G, Randeva, H.S, Kumar, S and Hutchinson, C.E 2014. Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/jc.2013-2036
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