Mitochondriotropic lanthanide nanorods: implications for multimodal imaging

Journal article

Singh, H., Sreejesh Sreedharan, Oyarzabal, E., Mahapatra, T. S., Green, N., Ian Shih, Y., Das, M., Thomas, J. A., Pramanik, S. K. and Das, A. 2020. Mitochondriotropic lanthanide nanorods: implications for multimodal imaging. Chemical Communications. 57, pp. 1-11. https://doi.org/10.1039/d0cc02698k
AuthorsSingh, H., Sreejesh Sreedharan, Oyarzabal, E., Mahapatra, T. S., Green, N., Ian Shih, Y., Das, M., Thomas, J. A., Pramanik, S. K. and Das, A.
Abstract

Organelles such as mitochondria, lysosome, and nucleus, are essential for controlling basic cellular operations and metabolism. Because mitochondria play a critical role in energy production and programmed cell death, they act as prime therapeutic targets for various diseases and dysfunctional states. In this study, a multifunctional nanoplatform based on lanthanide upconverting nanorods is developed for concurrent mitochondria-targeted fluorescence imaging and preclinical MRI. This study provides critical insights into the spectral profiles of mitochondria and paves the way to developing novel, multimodal nanoprobes for mitochondria-targeted theranostics.

Keywordsmitochondria; lysosome; nucleus
Year2020
JournalChemical Communications
Journal citation57, pp. 1-11
PublisherRoyal Society of Chemistry
ISSN1364-548X
Digital Object Identifier (DOI)https://doi.org/10.1039/d0cc02698k
Web address (URL)https://eprints.whiterose.ac.uk/165875/
https://doi.org/10.1039/D0CC02698K
Output statusPublished
Publication dates22 May 2020
Publication process dates
Accepted21 May 2020
Deposited12 Jul 2024
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