Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

Journal article

Saeed, H. K., Sreejesh Sreedharan and Thomas, J. A. 2020. Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics. Chemical Communications. 56 (10), pp. 1464-80. https://doi.org/10.1039/c9cc09312e
AuthorsSaeed, H. K., Sreejesh Sreedharan and Thomas, J. A.
Abstract

This review discusses the advantages of using luminescent d6-transition-metal complexes as cell probes for optical microscopy. In particular it focusses on the Thomas group's use of specific complexes as “building blocks” toward the construction of biomolecular binding substrates, with DNA being a particular target. Using this approach, a range of new imaging probes for conventional optical microscopy, nanoscopy and transmission electron microscopy have been identified. Through selection of specific metal centres and by substitution of coordinated ligands we illustrate how new chemotherapeutics, photo-therapeutics, and theranostics have been identified and developed from the original architectures.

Keywordsluminescent d6-transition-metal complexes; cell probes ; chemotherapeutics
Year2020
JournalChemical Communications
Journal citation56 (10), pp. 1464-80
PublisherAmerican Chemical Society
ISSN1364-548X
Digital Object Identifier (DOI)https://doi.org/10.1039/c9cc09312e
Web address (URL)https://eprints.whiterose.ac.uk/157419/
https://doi.org/10.1039/C9CC09312E
Output statusPublished
Publication dates10 Jan 2020
Publication process dates
Deposited12 Jul 2024
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