Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies

Journal article

Saeed, H.K., Jarman, P.J., Archer, S., Sreedharan, S., Saeed, I.Q., Mckenzie, L.K., Weinstein, J.A., Buurma, N.J., Smythe, C.G. and Thomas, J.A. 2017. Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies. Angewandte Chemie. 56 (41), pp. 12628-12633. https://doi.org/10.1002/ange.201707350
AuthorsSaeed, H.K., Jarman, P.J., Archer, S., Sreedharan, S., Saeed, I.Q., Mckenzie, L.K., Weinstein, J.A., Buurma, N.J., Smythe, C.G. and Thomas, J.A.
Abstract

Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.

KeywordsOrganometallic chemistry; Photochemistry; Bioinorganic chemistry; Dna
Year2017
JournalAngewandte Chemie
Journal citation56 (41), pp. 12628-12633
PublisherWiley
ISSN0044-8249
Digital Object Identifier (DOI)https://doi.org/10.1002/ange.201707350
Web address (URL)https://eprints.whiterose.ac.uk/120365/
http://dx.doi.org/10.1002/ange.201707350
Output statusPublished
Publication dates18 Aug 2017
Publication process dates
Deposited18 Oct 2018, 15:58
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ContributorsUniversity of Sheffield, Cardiff University, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Physical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK, Physical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK, Department of Biomedical Science; University of Sheffield; Sheffield S10 2TN UK and Department of Chemistry; University of Sheffield; Sheffield S3 7HF UK
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