Sreejesh Sreedharan
| Name | Sreejesh Sreedharan |
|---|---|
| Job title | Lecturer in Biomedical and Clinical Sciences |
| Research institute | College of Science and Engineering |
| ORCID | https://orcid.org/0000-0001-9523-0404 |
Research outputs
Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions
Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456Nanoparticles for super-resolution microscopy: intracellular delivery and molecular targeting
Sumit Kumar Pramanik, Sreejesh Sreedharan, Rajeshwari Tiwari, Sourav Dutta, Noufal Kandoth, Surajit Barman, Stephen O Aderinto, Samit Chattopadhyay, Amitava Das and Jim A Thomas 2022. Nanoparticles for super-resolution microscopy: intracellular delivery and molecular targeting. Chemical Society Reviews. 51, pp. 9882-9916. https://doi.org/10.1039/d1cs00605cUltrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria
Sheik Saleem Pasha, Amrita Banerjee, Sreejesh Sreedharan, Soumendra Singh, Noufal Kandoth, Katherine A. Vallis, Samir Kumar Pal, Sumit Kumar Pramanik and Amitava Das 2022. Ultrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria. Inorganic Chemistry. 61 (33), p. 13115–13124. https://doi.org/10.1021/acs.inorgchem.2c01761Surface functionalized perovskite nanocrystals: a design strategy for organelle-specific fluorescence lifetime multiplexing
Anik Kumar Dey, Subhadeep Das, Sharon Mary Jose, Sreejesh Sreedharan, Noufal Kandoth, Surajit Barman, Abhijit Patra, Amitava Das and Sumit Kumar Pramanik 2024. Surface functionalized perovskite nanocrystals: a design strategy for organelle-specific fluorescence lifetime multiplexing. Chemical Science. pp. 1-10. https://doi.org/10.1039/d4sc01447bFrom Chemotherapy to Phototherapy – Changing the Therapeutic Action of a Metallo-Intercalating RuII-ReI Luminescent System by Switching its Sub-Cellular Location
Saeed, H.K.,, Jarman, P.J., Sreedharan, S., Mowll, R., Auty, A.J., Chauvet, A.A., Smythe, C.G., de la Serna, J.B. and Thomas, J.A. 2023. From Chemotherapy to Phototherapy – Changing the Therapeutic Action of a Metallo-Intercalating RuII-ReI Luminescent System by Switching its Sub-Cellular Location. Chemistry: A European Journal . 29 (34), pp. 1-6. https://doi.org/10.1002/chem.202300617A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA
Dröge, F., Noakes, F.F., Archer, S.A., Sreedharan, S., Raza, A., Robertson, C.C., MacNeil, S., Haycock, J.W., Carson, H., Meijer, A.J. and Smythe, C.G. 2021. A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA. Journal of the American Chemical Society. 143 (48), p. 20442–20453. https://doi.org/10.1021/jacs.1c10325Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics
Saeed, H. K., Sreejesh Sreedharan and Thomas, J. A. 2020. Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics. Chemical Communications. 56 (10), pp. 1464-80. https://doi.org/10.1039/c9cc09312eMaking the Right Link to Theranostics: The Photophysical and Biological Properties of Dinuclear RuII–ReI dppz Complexes Depend on Their Tether
Hiwa K. Saeed, Sreejesh Sreedharan, Paul J. Jarman, Stuart A. Archer, Simon D. Fairbanks, Simon P. Foxon, Alexander J. Auty, Dimitri Chekulaev, Theo Keane, Anthony J. H. M. Meijer, Julia A. Weinstein, Carl G. W. Smythe, Jorge Bernardino de la Serna and Jim A. Thomas 2020. Making the Right Link to Theranostics: The Photophysical and Biological Properties of Dinuclear RuII–ReI dppz Complexes Depend on Their Tether. Journal of the American Chemical Society. 142 (2), p. 1101–1111. https://doi.org/10.1021/jacs.9b12564Nanocarriers used as probes for super-resolution microscopy
Sreejesh Sreedharan, Tiwari, S., Tyde, D., Aderinto, S. O., Pramanik, S. K., Das, A. and Thomas, J. A. 2020. Nanocarriers used as probes for super-resolution microscopy. Materials Chemistry Frontiers. 5 (3), pp. 1268-1282. https://doi.org/10.1039/d0qm00684jMitochondriotropic lanthanide nanorods: implications for multimodal imaging
Singh, H., Sreejesh Sreedharan, Oyarzabal, E., Mahapatra, T. S., Green, N., Ian Shih, Y., Das, M., Thomas, J. A., Pramanik, S. K. and Das, A. 2020. Mitochondriotropic lanthanide nanorods: implications for multimodal imaging. Chemical Communications. 57, pp. 1-11. https://doi.org/10.1039/d0cc02698kPhotoactivable Prodrug for Simultaneous Release of Mertansine, and CO along with a BODIPY Derivative as a Luminescent Marker in Mitochondria: A Proof of Concept for NIR Image-Guided Cancer Therapy
Tiwari, R., Shinde, P.S., Sreedharan, S., Dey, A.K., Vallis, K.A., Mhaske, S.B., Pramanik, S.K. and Das, A 2020. Photoactivable Prodrug for Simultaneous Release of Mertansine, and CO along with a BODIPY Derivative as a Luminescent Marker in Mitochondria: A Proof of Concept for NIR Image-Guided Cancer Therapy. Chemical Science. 12 (7), pp. 2667-2673. https://doi.org/10.1039/d0sc06270gTracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe
Ali, F., Aute, S., Sreedharan, S., Anila, H.A., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2018. Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe. Chemical Communications. 54 (15), pp. 1849-185. https://doi.org/10.1039/c7cc09433gPolysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging
Sreedharan, S., Hoskere, A., Ali, F., Smythe, G.C., Thomas, J. A. and Das, A. 2018. Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging. Chemical Communications. 54 (30), pp. 3735-3738. https://doi.org/10.1039/c8cc01332bMitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties
Sinopoli, A., Sreedharan, S., Jarman, P.J., Robinson, D., Clemmet, C., Scattergood, P.A., Rice, C.R., Smythe, C.G., Thomas, J.A. and Elliott, P.I. 2018. Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties. Dalton Transactions. 47 (14), pp. 4931-4940. https://doi.org/10.1039/c8dt00046hA Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells
Singh, H., Sreedharan, S., Tiwari, R., Walther, C., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells. Crystal Growth & Design. 18 (11), pp. 7199-7206. https://doi.org/10.1021/acs.cgd.8b01409Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging
Singh, H., Sreedharan, S., Tiwari, K., Green, N.H., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging. Chemical Communications. 55 (4), pp. 521-524. https://doi.org/10.1039/c8cc08610aMitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release
Pramanik, S.K., Sreedharan, S., Singh, H., Khan, M., Tiwari, K., Shiras, A., Smythe, C., Thomas, J.A. and Das, A. 2018. Mitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release. Bioconjugate Chemistry. 29 (11), pp. 3532-3543. https://doi.org/10.1021/acs.bioconjchem.8b00460Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles
Pramanik, S.K., Sreedharan, S., Singh, H., Green, N.H., Smythe, C., Thomas, J.A. and Das, A. 2017. Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles. Chemical Communications. 53 (94), pp. 12672-12675. https://doi.org/10.1039/c7cc08185eMultimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria
Sreedharan, S., Gill, M.R., Garcia, E., Saeed, H.K., Robinson, D., Byrne, A., Cadby, A., Keyes, T.E., Smythe, C., Pellett, P. and Bernardino de la Serna, J. 2017. Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria. Journal of the American Chemical Society. 139 (4), pp. 15907-15913. https://doi.org/10.1021/jacs.7b08772A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells
Ali, F., Sreedharan, S., Ashoka, A.H., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2017. A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells. Analytical Chemistry. 89 (22), pp. 12087-12093. https://doi.org/10.1021/acs.analchem.7b02567Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies
Saeed, H.K., Jarman, P.J., Archer, S., Sreedharan, S., Saeed, I.Q., Mckenzie, L.K., Weinstein, J.A., Buurma, N.J., Smythe, C.G. and Thomas, J.A. 2017. Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies. Angewandte Chemie. 56 (41), pp. 12628-12633. https://doi.org/10.1002/ange.201707350Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents
Song, L., Guo, Y., Roebuck, D., Chen, C., Yang, M., Yang, Z., Sreedharan, S., Glover, C., Thomas, J.A., Liu, D. and Guo, S. Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents. ACS Applied Materials & Interfaces. 7 (33), pp. 18707-18716. https://doi.org/10.1021/acsami.5b05228514
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