Sreejesh Sreedharan

NameSreejesh Sreedharan
Job titleLecturer in Biomedical and Clinical Sciences
Research instituteCollege of Science and Engineering
ORCIDhttps://orcid.org/0000-0001-9523-0404

Research outputs

Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions

Sreejesh Sreedharan, Zouganelis, G., Samantha J Drake, Gyanendra Tripathi and Ali Kermanizadeh 2022. Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. pp. 1-27. https://doi.org/10.1080/10937404.2022.2153456

Nanoparticles for super-resolution microscopy: intracellular delivery and molecular targeting

Sumit Kumar Pramanik, Sreejesh Sreedharan, Rajeshwari Tiwari, Sourav Dutta, Noufal Kandoth, Surajit Barman, Stephen O Aderinto, Samit Chattopadhyay, Amitava Das and Jim A Thomas 2022. Nanoparticles for super-resolution microscopy: intracellular delivery and molecular targeting. Chemical Society Reviews. 51, pp. 9882-9916. https://doi.org/10.1039/d1cs00605c

Ultrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria

Sheik Saleem Pasha, Amrita Banerjee, Sreejesh Sreedharan, Soumendra Singh, Noufal Kandoth, Katherine A. Vallis, Samir Kumar Pal, Sumit Kumar Pramanik and Amitava Das 2022. Ultrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria. Inorganic Chemistry. 61 (33), p. 13115–13124. https://doi.org/10.1021/acs.inorgchem.2c01761

Surface functionalized perovskite nanocrystals: a design strategy for organelle-specific fluorescence lifetime multiplexing

Anik Kumar Dey, Subhadeep Das, Sharon Mary Jose, Sreejesh Sreedharan, Noufal Kandoth, Surajit Barman, Abhijit Patra, Amitava Das and Sumit Kumar Pramanik 2024. Surface functionalized perovskite nanocrystals: a design strategy for organelle-specific fluorescence lifetime multiplexing. Chemical Science. pp. 1-10. https://doi.org/10.1039/d4sc01447b

From Chemotherapy to Phototherapy – Changing the Therapeutic Action of a Metallo-Intercalating RuII-ReI Luminescent System by Switching its Sub-Cellular Location

Saeed, H.K.,, Jarman, P.J., Sreedharan, S., Mowll, R., Auty, A.J., Chauvet, A.A., Smythe, C.G., de la Serna, J.B. and Thomas, J.A. 2023. From Chemotherapy to Phototherapy – Changing the Therapeutic Action of a Metallo-Intercalating RuII-ReI Luminescent System by Switching its Sub-Cellular Location. Chemistry: A European Journal . 29 (34), pp. 1-6. https://doi.org/10.1002/chem.202300617

A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA

Dröge, F., Noakes, F.F., Archer, S.A., Sreedharan, S., Raza, A., Robertson, C.C., MacNeil, S., Haycock, J.W., Carson, H., Meijer, A.J. and Smythe, C.G. 2021. A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA. Journal of the American Chemical Society. 143 (48), p. 20442–20453. https://doi.org/10.1021/jacs.1c10325

Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

Saeed, H. K., Sreejesh Sreedharan and Thomas, J. A. 2020. Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics. Chemical Communications. 56 (10), pp. 1464-80. https://doi.org/10.1039/c9cc09312e

Making the Right Link to Theranostics: The Photophysical and Biological Properties of Dinuclear RuII–ReI dppz Complexes Depend on Their Tether

Hiwa K. Saeed, Sreejesh Sreedharan, Paul J. Jarman, Stuart A. Archer, Simon D. Fairbanks, Simon P. Foxon, Alexander J. Auty, Dimitri Chekulaev, Theo Keane, Anthony J. H. M. Meijer, Julia A. Weinstein, Carl G. W. Smythe, Jorge Bernardino de la Serna and Jim A. Thomas 2020. Making the Right Link to Theranostics: The Photophysical and Biological Properties of Dinuclear RuII–ReI dppz Complexes Depend on Their Tether. Journal of the American Chemical Society. 142 (2), p. 1101–1111. https://doi.org/10.1021/jacs.9b12564

Nanocarriers used as probes for super-resolution microscopy

Sreejesh Sreedharan, Tiwari, S., Tyde, D., Aderinto, S. O., Pramanik, S. K., Das, A. and Thomas, J. A. 2020. Nanocarriers used as probes for super-resolution microscopy. Materials Chemistry Frontiers. 5 (3), pp. 1268-1282. https://doi.org/10.1039/d0qm00684j

Mitochondriotropic lanthanide nanorods: implications for multimodal imaging

Singh, H., Sreejesh Sreedharan, Oyarzabal, E., Mahapatra, T. S., Green, N., Ian Shih, Y., Das, M., Thomas, J. A., Pramanik, S. K. and Das, A. 2020. Mitochondriotropic lanthanide nanorods: implications for multimodal imaging. Chemical Communications. 57, pp. 1-11. https://doi.org/10.1039/d0cc02698k

Photoactivable Prodrug for Simultaneous Release of Mertansine, and CO along with a BODIPY Derivative as a Luminescent Marker in Mitochondria: A Proof of Concept for NIR Image-Guided Cancer Therapy

Tiwari, R., Shinde, P.S., Sreedharan, S., Dey, A.K., Vallis, K.A., Mhaske, S.B., Pramanik, S.K. and Das, A 2020. Photoactivable Prodrug for Simultaneous Release of Mertansine, and CO along with a BODIPY Derivative as a Luminescent Marker in Mitochondria: A Proof of Concept for NIR Image-Guided Cancer Therapy. Chemical Science. 12 (7), pp. 2667-2673. https://doi.org/10.1039/d0sc06270g

Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

Ali, F., Aute, S., Sreedharan, S., Anila, H.A., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2018. Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe. Chemical Communications. 54 (15), pp. 1849-185. https://doi.org/10.1039/c7cc09433g

Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging

Sreedharan, S., Hoskere, A., Ali, F., Smythe, G.C., Thomas, J. A. and Das, A. 2018. Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging. Chemical Communications. 54 (30), pp. 3735-3738. https://doi.org/10.1039/c8cc01332b

Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties

Sinopoli, A., Sreedharan, S., Jarman, P.J., Robinson, D., Clemmet, C., Scattergood, P.A., Rice, C.R., Smythe, C.G., Thomas, J.A. and Elliott, P.I. 2018. Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: syntheses and cellular imaging properties. Dalton Transactions. 47 (14), pp. 4931-4940. https://doi.org/10.1039/c8dt00046h

A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells

Singh, H., Sreedharan, S., Tiwari, R., Walther, C., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells. Crystal Growth & Design. 18 (11), pp. 7199-7206. https://doi.org/10.1021/acs.cgd.8b01409

Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging

Singh, H., Sreedharan, S., Tiwari, K., Green, N.H., Smythe, C., Pramanik, S.K., Thomas, J.A. and Das, A. 2018. Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging. Chemical Communications. 55 (4), pp. 521-524. https://doi.org/10.1039/c8cc08610a

Mitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release

Pramanik, S.K., Sreedharan, S., Singh, H., Khan, M., Tiwari, K., Shiras, A., Smythe, C., Thomas, J.A. and Das, A. 2018. Mitochondria Targeting Non-Isocyanate-Based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release. Bioconjugate Chemistry. 29 (11), pp. 3532-3543. https://doi.org/10.1021/acs.bioconjchem.8b00460

Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles

Pramanik, S.K., Sreedharan, S., Singh, H., Green, N.H., Smythe, C., Thomas, J.A. and Das, A. 2017. Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles. Chemical Communications. 53 (94), pp. 12672-12675. https://doi.org/10.1039/c7cc08185e

Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria

Sreedharan, S., Gill, M.R., Garcia, E., Saeed, H.K., Robinson, D., Byrne, A., Cadby, A., Keyes, T.E., Smythe, C., Pellett, P. and Bernardino de la Serna, J. 2017. Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria. Journal of the American Chemical Society. 139 (4), pp. 15907-15913. https://doi.org/10.1021/jacs.7b08772

A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells

Ali, F., Sreedharan, S., Ashoka, A.H., Saeed, H.K., Smythe, C.G., Thomas, J.A. and Das, A. 2017. A Super-Resolution Probe To Monitor HNO Levels in the Endoplasmic Reticulum of Cells. Analytical Chemistry. 89 (22), pp. 12087-12093. https://doi.org/10.1021/acs.analchem.7b02567

Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies

Saeed, H.K., Jarman, P.J., Archer, S., Sreedharan, S., Saeed, I.Q., Mckenzie, L.K., Weinstein, J.A., Buurma, N.J., Smythe, C.G. and Thomas, J.A. 2017. Homo- and Heteroleptic Phototoxic Dinuclear Metallo-Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies. Angewandte Chemie. 56 (41), pp. 12628-12633. https://doi.org/10.1002/ange.201707350

Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents

Song, L., Guo, Y., Roebuck, D., Chen, C., Yang, M., Yang, Z., Sreedharan, S., Glover, C., Thomas, J.A., Liu, D. and Guo, S. Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents. ACS Applied Materials & Interfaces. 7 (33), pp. 18707-18716. https://doi.org/10.1021/acsami.5b05228
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