Compositional constraints and selection forces dictate codon usage in human bocavirus

Journal article


Khandia, R.,, Singhal, S., Kumar, U., Shende, K., Pandey, M.K., Povetkin, S.N., Rzhepakovsky, I.V., Raut, A., Alexiou, A., Dhama, K., Zouganelis, G. and Khan. A. A. 2023. Compositional constraints and selection forces dictate codon usage in human bocavirus. Journal of King Saud University - Science. 35 (6), pp. 1-11. https://doi.org/10.1016/j.jksus.2023.102726
AuthorsKhandia, R.,, Singhal, S., Kumar, U., Shende, K., Pandey, M.K., Povetkin, S.N., Rzhepakovsky, I.V., Raut, A., Alexiou, A., Dhama, K., Zouganelis, G. and Khan. A. A.
Abstract

Human bocavirus (HBoV), of the genus Bocaparvovirus, is a small, non-enveloped linear single-stranded DNA virus of the Parvoviridae family. The virus is known to cause severe life-threatening respiratory tract infections in pediatric patients. Considering its deleterious impacts on respiratory, gastrointestinal, and hematological health, we prompted to investigate codon usage patterns, parity, neutrality, Nc-GC3 analysis, gene expression, Intrinsic codon bias index (ICDI), Codon bias index (CBI), Relative codon deoptimization index (RCDI), Translational selection (P2), and measure independent of length and composition (MILC) to investigate the role of evolutionary constraints such as selection and mutation and molecular patterns present in HBoV.

KeywordsHuman bocavirus; Influenza-like illness; Selection pressure; Compositional constraint; Ground-glass-like opacity
Year2023
JournalJournal of King Saud University - Science
Journal citation35 (6), pp. 1-11
PublisherElsevier
King Saud University
ISSN 2213-686X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jksus.2023.102726
Web address (URL)https://www.sciencedirect.com/science/article/pii/S101836472300188X?via%3Dihub
Output statusPublished
Publication dates
Online26 May 2023
Publication process dates
Accepted22 May 2023
Deposited01 Aug 2023
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