Compositional constraints and selection forces dictate codon usage in human bocavirus
Journal article
Khandia, R.,, Singhal, S., Kumar, U., Shende, K., Pandey, M.K., Povetkin, S.N., Rzhepakovsky, I.V., Raut, A., Alexiou, A., Dhama, K., Zouganelis, G. and Khan. A. A. 2023. Compositional constraints and selection forces dictate codon usage in human bocavirus. Journal of King Saud University - Science. 35 (6), pp. 1-11. https://doi.org/10.1016/j.jksus.2023.102726
| Authors | Khandia, R.,, Singhal, S., Kumar, U., Shende, K., Pandey, M.K., Povetkin, S.N., Rzhepakovsky, I.V., Raut, A., Alexiou, A., Dhama, K., Zouganelis, G. and Khan. A. A. |
|---|---|
| Abstract | Human bocavirus (HBoV), of the genus Bocaparvovirus, is a small, non-enveloped linear single-stranded DNA virus of the Parvoviridae family. The virus is known to cause severe life-threatening respiratory tract infections in pediatric patients. Considering its deleterious impacts on respiratory, gastrointestinal, and hematological health, we prompted to investigate codon usage patterns, parity, neutrality, Nc-GC3 analysis, gene expression, Intrinsic codon bias index (ICDI), Codon bias index (CBI), Relative codon deoptimization index (RCDI), Translational selection (P2), and measure independent of length and composition (MILC) to investigate the role of evolutionary constraints such as selection and mutation and molecular patterns present in HBoV. |
| Keywords | Human bocavirus; Influenza-like illness; Selection pressure; Compositional constraint; Ground-glass-like opacity |
| Year | 2023 |
| Journal | Journal of King Saud University - Science |
| Journal citation | 35 (6), pp. 1-11 |
| Publisher | Elsevier |
| King Saud University | |
| ISSN | 2213-686X |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jksus.2023.102726 |
| Web address (URL) | https://www.sciencedirect.com/science/article/pii/S101836472300188X?via%3Dihub |
| Output status | Published |
| Publication dates | |
| Online | 26 May 2023 |
| Publication process dates | |
| Accepted | 22 May 2023 |
| Deposited | 01 Aug 2023 |
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