Non coding RNAs in aortic aneurysmal disease.

Journal article


Duggirala, A., Francesca Delogu, Timothy G Angelini, Tanya Smith, Massimo Caputo, Cha Rajakaruna and Costanza Emanueli 2015. Non coding RNAs in aortic aneurysmal disease. Frontiers in genetics. Vol 6 (Issue APR, Article: 125). https://doi.org/10.3389/fgene.2015.00125
AuthorsDuggirala, A., Francesca Delogu, Timothy G Angelini, Tanya Smith, Massimo Caputo, Cha Rajakaruna and Costanza Emanueli
Abstract

An aneurysm is a local dilatation of a vessel wall which is >50% its original diameter. Within the spectrum of cardiovascular diseases, aortic aneurysms are among the most challenging to treat. Most patients present acutely after aneurysm rupture or dissection from a previous asymptomatic condition and are managed by open surgical or endovascular repair. In addition, patients may harbor concurrent disease contraindicating surgical intervention. Collectively, these factors have driven the search for alternative methods of identifying, monitoring and treating aortic aneurisms using less invasive approaches. Non-coding RNA (ncRNAs) are emerging as new fundamental regulators of gene expression. The small microRNAs have opened the field of ncRNAs capturing the attention of basic and clinical scientists for their potential to become new therapeutic targets and clinical biomarkers for aortic aneurysm. More recently, long ncRNAs (lncRNAs) have started to be actively investigated, leading to first exciting reports, which further suggest their important and yet largely unexplored contribution to vascular physiology and disease. This review introduces the different ncRNA types and focus at ncRNA roles in aorta aneurysms. We discuss the potential of therapeutic interventions targeting ncRNAs and we describe the research models allowing for mechanistic studies and clinical translation attempts for controlling aneurysm progression. Furthermore, we discuss the potential role of microRNAs and lncRNAs as clinical biomarkers.

KeywordsAneurysms; ; Biomarkers; ; Long non-coding RNAs; ; microRNAs; ; Therapeutic targets; ; Vascular cells
Year2015
JournalFrontiers in genetics
Journal citationVol 6 (Issue APR, Article: 125)
PublisherFrontiers
ISSN16648021
Digital Object Identifier (DOI)https://doi.org/10.3389/fgene.2015.00125
Web address (URL)https://europepmc.org/articles/PMC4381652
https://www.scopus.com/record/display.uri?eid=2-s2.0-84933509543&origin=resultslist&sort=plf-f&src=s&st1=Non+coding+RNAs+in+aortic+aneurysmal+disease.&sid=d08c048101e8656bc0cb9e0f398ba610&sot=b&sdt=b&sl=60&s=TITLE-ABS-KEY%28Non+coding+RNAs+in+aortic+aneurysmal+disease.%29&relpos=4&citeCnt=30&searchTerm=
https://pubmed.ncbi.nlm.nih.gov/25883602/
Output statusPublished
Publication dates01 Apr 2015
Publication process dates
Accepted16 Mar 2015
Deposited08 Jun 2023
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