Aparna Duggirala

NameAparna Duggirala
Job titleLecturer in Clinical Genetics
Research instituteCollege of Science and Engineering
ORCIDhttps://orcid.org/0000-0002-5311-0663

Research outputs

Molecular effects of physical activity and body composition: a systematic review and meta-analysis

Chambers, J., Roscoe, C., Chidley, C., Wisniewska, A. and Duggirala, A. 2025. Molecular effects of physical activity and body composition: a systematic review and meta-analysis. International Journal of Environmental Research and Public Health. 22 (4), pp. 1-22. https://doi.org/https://doi.org/10.3390/ijerph22040637

Differential expression of maternal plasma micrornas and their respective gene targets can predict early fetal growth restriction

Kolawole, E., Duggirala, A., Gronow, O., Wisniewska, A., Hu, J. and Tan, B. K. 2025. Differential expression of maternal plasma micrornas and their respective gene targets can predict early fetal growth restriction. Life. 15 (2), pp. 1-16. https://doi.org//10.3390/life15020167

Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function.

Duggirala, A. 2018. Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function. Scientific Reports. Vol 8 (Issue 1, Article: 4904). https://doi.org/10.1038/s41598-018-23199-4

Systematic identification of genetic influences on methylation across the human life course.

Tom R. Gaunt, Hashem A. Shihab, Gibran Hemani,, Josine L. Min, Geoff Woodward, Oliver Lyttleton, Jie Zheng, Duggirala, A., Wendy L. McArdle, Karen Ho, Susan M. Ring, David M. Evans, George Davey Smith and Caroline L. Relton 2018. Systematic identification of genetic influences on methylation across the human life course. Genome biology. Vol 17 (2016, Article: 61). https://doi.org/10.1186/s13059-016-0926-z

The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP.

Tomomi E. Kimura, Duggirala, A., Madeleine C. Smith, Stephen White, Graciela B. Sala-Newby, Andrew C. Newby and Mark Bond 2015. The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. Journal of molecular and cellular cardiology. Vol 90 (January 2016), pp. 1-10. https://doi.org/10.1016/j.yjmcc.2015.11.024

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

Relton CL, Gaunt T, McArdle W, Ho K, Duggirala, A., Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM and Davey Smith G 2015. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). International journal of epidemiology. Vol 44 (Issue 4), pp. 1181-1190. https://doi.org/10.1093/ije/dyv072

Non coding RNAs in aortic aneurysmal disease.

Duggirala, A., Francesca Delogu, Timothy G Angelini, Tanya Smith, Massimo Caputo, Cha Rajakaruna and Costanza Emanueli 2015. Non coding RNAs in aortic aneurysmal disease. Frontiers in genetics. Vol 6 (Issue APR, Article: 125). https://doi.org/10.3389/fgene.2015.00125

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1.

Duggirala, A., Kimura TE, Sala-Newby GB, Johnson JL, Wu YJ, Newby AC and Bond M 2014. cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1. Journal of molecular and cellular cardiology. Vol 79 (Feb 2015), pp. 157 - 168. https://doi.org/10.1016/j.yjmcc.2014.11.012

Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells.

Tomomi E. Kimura, Duggirala, A., Charles C.T. Hindmarch, Richard C. Hewer, Mei-Zhen Cui, Andrew C. Newby and Mark Bond 2014. Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. Journal of molecular and cellular cardiology. Vol 72 (July 2014), pp. 9 - 19. https://doi.org/10.1016/j.yjmcc.2014.02.001

Differences in smoking associated DNA methylation patterns in South Asians and Europeans.

Hannah R Elliott, Tillin, Therese, McArdle, Wendy L., Ho, Karen, Duggirala, A., Frayling, Tim M., Smith, George Davey, Hughes, Alun D., Chaturvedi, Nish and Relton, Caroline L. 2014. Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clinical Epigenetics. Vol 6 (2014), p. 4. https://doi.org/10.1186/1868-7083-6-4
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