The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing.

Journal article


Tallis, Jason, Higgins, Matthew F., Seebacher, Frank, Cox, Val M., Duncan, Michael J. and James, Rob S. 2017. The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing. The Journal of Experimental Biology. https://doi.org/10.1242/jeb.166603
AuthorsTallis, Jason, Higgins, Matthew F., Seebacher, Frank, Cox, Val M., Duncan, Michael J. and James, Rob S.
Abstract

Decreased skeletal muscle performance with increasing age is strongly associated with reduced mobility and quality of life. Increased physical activity is a widely prescribed method of reducing the detrimental effects of ageing on skeletal muscle contractility. The present study uses isometric and work loop testing protocols to uniquely investigate the effects of 8 weeks of voluntary wheel running on the contractile performance of isolated dynapenic soleus and diaphragm muscles of 38 week old CD1 mice. When compared to untrained controls, voluntary wheel running induced significant improvements in maximal isometric stress and work loop power, a reduced resistance to fatigue, but greater cumulative work during fatiguing work loop contractions in isolated muscle. These differences occurred without appreciable changes in LDH, CS, SERCA or MHC expression synonymous with this form of training in younger rodent models. Despite the given improvement in contractile performance, the average running distance significantly declined over the course of the training period, indicating that this form of training may not be sufficient to fully counteract the longer term ageing induced decline in skeletal muscle contractile performance. Although these results indicate that regular low intensity physical activity may be beneficial in offsetting the age-related decline in skeletal muscle contractility, the present findings infer that future work focusing on the maintenance of a healthy body mass with increasing age and its effects on myosin-actin cross bridge kinetics and Ca(2+) handling, is needed to clarify the mechanisms causing the improved contractile performance in trained dynapenic skeletal muscle.

KeywordsContractile performance; Dynapenia; Sarcopenia; Training; Weight management
Year2017
JournalThe Journal of Experimental Biology
PublisherThe Company of Biologists Ltd.
ISSN14779145
Digital Object Identifier (DOI)https://doi.org/10.1242/jeb.166603
Web address (URL)http://hdl.handle.net/10545/621822
hdl:10545/621822
Publication dates17 Aug 2017
Publication process dates
Deposited24 Aug 2017, 14:22
Accepted10 Aug 2017
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Archived with thanks to The Journal of experimental biology

ContributorsCoventry University, University of Derby and University of Sydney
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