Inflammation, lipid (per)oxidation, and redox regulation

Journal article


Dias, Irundika H.K., Milic, Ivana, Heiss, Christian, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew and Griffiths, Helen R. 2020. Inflammation, lipid (per)oxidation, and redox regulation. Antioxidant and Redox Signaling. https://doi.org/10.1089/ars.2020.8022
AuthorsDias, Irundika H.K., Milic, Ivana, Heiss, Christian, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew and Griffiths, Helen R.
Abstract

Significance: Inflammation increases during the aging process. It is linked to mitochondrial dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial macromolecules are critical targets of oxidative damage; they contribute to respiratory uncoupling with increased ROS production, redox stress, and a cycle of senescence, cytokine production, and impaired oxidative phosphorylation. Targeting the formation or accumulation of oxidized biomolecules, particularly oxidized lipids, in immune cells and mitochondria could be beneficial for age-related inflammation and comorbidities.

Recent Advances: Inflammation is central to age-related decline in health and exhibits a complex relationship with mitochondrial redox state and metabolic function. Improvements in mass spectrometric methods have led to the identification of families of oxidized phospholipids (OxPLs), cholesterols, and fatty acids that increase during inflammation and which modulate nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPARγ), activator protein 1 (AP1), and NF-κB redox-sensitive transcription factor activity.

Critical Issues: The kinetic and spatial resolution of the modified lipidome has profound and sometimes opposing effects on inflammation, promoting initiation at high concentration and resolution at low concentration of OxPLs.

Future Directions: There is an emerging opportunity to prevent or delay age-related inflammation and vascular comorbidity through a resolving (oxy)lipidome that is dependent on improving mitochondrial quality control and restoring redox homeostasis.

KeywordsClinical Biochemistry; Cell Biology; Biochemistry; Physiology; Molecular Biology; Anti-inflammatory; Eicosanoids; Metabolism; Oxidized phospholipids; Oxysterols; Reactive oxygen species.
Year2020
JournalAntioxidant and Redox Signaling
Antioxidants & Redox Signaling
PublisherMary Ann Liebert Inc
ISSN1523-0864
1557-7716
Digital Object Identifier (DOI)https://doi.org/10.1089/ars.2020.8022
Web address (URL)http://hdl.handle.net/10545/624647
https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/
http://creativecommons.org/licenses/by-nc-nd/4.0/
hdl:10545/624647
Publication dates28 Feb 2020
Publication process dates
Deposited01 Apr 2020, 16:03
AcceptedJan 2020
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Attribution-NonCommercial-NoDerivatives 4.0 International

ContributorsAston University, Birmingham, West Midlands, UK, University of Surrey and University of Cologne
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