Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis

Journal article


Ademowo, OS. and Dias, I. H. K 2022. Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis. Redox Experimental Medicine. 2022 (1), pp. 116 -126. https://doi.org/10.1530/REM-22-0009
AuthorsAdemowo, OS. and Dias, I. H. K
Abstract

Despite decades of research, the cause and series of events underlying the advancement of Alzheimer’s disease (AD) has not yet been established. Lipids and especially cholesterol levels have been proposed to be implicated in AD. Several studies have been undertaken and many ongoing in different directions looking at the importance of circulating cholesterols and oxidised cholesterols in Alzheimer’s disease with inconsistent methods and results. This meta-analysis aims to systematically analyse available data describing the involvement of oxidised cholesterols in Mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We conducted a systematic literature search of 6 databases MEDLINE (PubMed), BIOSIS (Web of Science), EMBASE (Elsevier), PsycNET, Scopus and Cochrane library for studies measuring oxysterols (24-hydroxycholesterol (24OHC); 26-hydroxycholesterol (26OHC) and 7-oxycholesterols) in serum or plasma from MCI / AD patients compared to age and gender matched cognitively normal controls. Data was analysed using the inverse variance and standard mean difference with random effect analysis model at 95% confidence interval for association between oxysterols and MCI / AD in Review Manager (RevMan) software version 5.4.1. 175 studies between January 2000 and April 2022 were identified by 2 independent researchers out of which 14 met the inclusion criteria and were analysed with a total of 957 controls, 469 MCI cases and 509 AD cases. The standard mean differences between MCI / AD participants and controls did not show any difference in the oxysterol levels except for 26OHC level which were higher in AD but not statistically significant.

Keywordsoxysterols; Alzheimer’s disease; serum; plasma; meta-analysis
Year2022
JournalRedox Experimental Medicine
Journal citation2022 (1), pp. 116 -126
Publisherbioscientifica
ISSN2755-158X
Digital Object Identifier (DOI)https://doi.org/10.1530/REM-22-0009
Web address (URL)https://rem.bioscientifica.com/configurable/content/journals$002frem$002f2022$002f1$002fREM-22-0009.xml?t:ac=journals%24002frem%24002f2022%24002f1%24002fREM-22-0009.xml
FunderAlzheimer's Research UK
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online01 Jul 2022
Publication process dates
Accepted28 Jun 2022
Deposited12 Aug 2022
Permalink -

https://repository.derby.ac.uk/item/9824y/circulating-oxysterols-in-alzheimer-s-disease-a-systematic-review-and-meta-analysis

Download files


Publisher's version
Redox Experimental Medicine_Ademowo 2022.pdf
License: CC BY 4.0
File access level: Open

  • 37
    total views
  • 11
    total downloads
  • 1
    views this month
  • 1
    downloads this month

Export as

Related outputs

Inflammation, lipid (per)oxidation, and redox regulation
Dias, Irundika H.K., Milic, Ivana, Heiss, Christian, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew and Griffiths, Helen R. 2020. Inflammation, lipid (per)oxidation, and redox regulation. Antioxidant and Redox Signaling. https://doi.org/10.1089/ars.2020.8022
Nutritional hormesis in a modern environment
Ademowo, O. Stella, Dias, H. K. Irundika, Pararasa, Chathyan and Griffiths, Helen R. 2018. Nutritional hormesis in a modern environment. in: The Science of Hormesis in Health and Longevity Elsevier.
Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis
Ademowo, Opeyemi S, Hernandez, Belinda, Collins, Emily, Rooney, Cathy, Fearon, Ursula, van Kuijk, Arno W, Tak, Paul-P, Gerlag, Danielle M, FitzGerald, Oliver and Pennington, Stephen R 2014. Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Annals of the Rheumatic Diseases. 75 (1), pp. 234-241. https://doi.org/10.1136/annrheumdis-2014-205417
Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids
Ademowo, Opeyemi S., Dias, Irundika H.K., Diaz-Sanchez, Lorena, Sanchez-Aranguren, Lissette, Stahl, Wilhelm and Griffiths, Helen R. 2020. Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-190923
Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity
Ademowo, Opeyemi Stella, Sharma, Praveen, Cockwell, Paul, Reis, Ana, Chapple, Iain L., Griffiths, Helen R. and Dias, Irundika H.K. 2019. Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity. Free Radical Biology and Medicine. 146, pp. 130-138. https://doi.org/10.1016/j.freeradbiomed.2019.10.012
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Ademowo, O. S., Dias, H. K. I., Burton, D. G. A. and Griffiths, H. R. 2017. Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? Biogerontology. 18 (6), pp. 859-879. https://doi.org/10.1007/s10522-017-9710-z
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio and Daiber, Andreas 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13, pp. 94-162. https://doi.org/10.1016/j.redox.2017.05.007
Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients
Ademowo, O.S., Dias, H.K.I., Milic, I., Devitt, A., Moran, R., Mulcahy, R., Howard, A.N., Nolan, J.M. and Griffiths, H.R. 2017. Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients. Free Radical Biology and Medicine. 108, pp. 77-85. https://doi.org/10.1016/j.freeradbiomed.2017.03.008