Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis

Journal article


Ademowo, OS. and Dias, I. H. K 2022. Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis. Redox Experimental Medicine. 2022 (1), pp. 116 -126. https://doi.org/10.1530/REM-22-0009
AuthorsAdemowo, OS. and Dias, I. H. K
Abstract

Despite decades of research, the cause and series of events underlying the advancement of Alzheimer’s disease (AD) has not yet been established. Lipids and especially cholesterol levels have been proposed to be implicated in AD. Several studies have been undertaken and many ongoing in different directions looking at the importance of circulating cholesterols and oxidised cholesterols in Alzheimer’s disease with inconsistent methods and results. This meta-analysis aims to systematically analyse available data describing the involvement of oxidised cholesterols in Mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We conducted a systematic literature search of 6 databases MEDLINE (PubMed), BIOSIS (Web of Science), EMBASE (Elsevier), PsycNET, Scopus and Cochrane library for studies measuring oxysterols (24-hydroxycholesterol (24OHC); 26-hydroxycholesterol (26OHC) and 7-oxycholesterols) in serum or plasma from MCI / AD patients compared to age and gender matched cognitively normal controls. Data was analysed using the inverse variance and standard mean difference with random effect analysis model at 95% confidence interval for association between oxysterols and MCI / AD in Review Manager (RevMan) software version 5.4.1. 175 studies between January 2000 and April 2022 were identified by 2 independent researchers out of which 14 met the inclusion criteria and were analysed with a total of 957 controls, 469 MCI cases and 509 AD cases. The standard mean differences between MCI / AD participants and controls did not show any difference in the oxysterol levels except for 26OHC level which were higher in AD but not statistically significant.

Keywordsoxysterols; Alzheimer’s disease; serum; plasma; meta-analysis
Year2022
JournalRedox Experimental Medicine
Journal citation2022 (1), pp. 116 -126
Publisherbioscientifica
ISSN2755-158X
Digital Object Identifier (DOI)https://doi.org/10.1530/REM-22-0009
Web address (URL)https://rem.bioscientifica.com/configurable/content/journals$002frem$002f2022$002f1$002fREM-22-0009.xml?t:ac=journals%24002frem%24002f2022%24002f1%24002fREM-22-0009.xml
FunderAlzheimer's Research UK
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File Access Level
Open
Output statusPublished
Publication dates
Online01 Jul 2022
Publication process dates
Accepted28 Jun 2022
Deposited12 Aug 2022
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