Effects of carotenoids on mitochondrial dysfunction
Journal article
Authors | Ademowo, S., Oyebode, O., Edward, R., Conway, M., Griffiths, H. and Dias, I. H. K. |
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Abstract | Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrial-derived ROS are associated with mitochondrial dysfunction, an early event in age-related diseases such as Alzheimer’s diseases (ADs) and in metabolic disorders including diabetes. AD post-mortem investigations of affected brain regions have shown the accumulation of oxidative damage to macromolecules, and oxidative stress has been considered |
Keywords | Carotenoids; oxidative stress; mitochondria; reactive oxygen species; astaxanthin |
Year | 2024 |
Journal | Biochemical Society Transactions |
Journal citation | 52 (1), p. 65–74 |
Publisher | Portland Press |
ISSN | 1470-8752 |
Digital Object Identifier (DOI) | https://doi.org/10.1042/BST20230193 |
Web address (URL) | https://portlandpress.com/biochemsoctrans/article/52/1/65/234092/Effects-of-carotenoids-on-mitochondrial |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 22 Feb 2024 |
Publication process dates | |
Accepted | 08 Feb 2024 |
Deposited | 04 Mar 2024 |
Supplemental file | File Access Level Open |
https://repository.derby.ac.uk/item/q4y23/effects-of-carotenoids-on-mitochondrial-dysfunction
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Publisher's version
Biochemical Society Transactions 2024.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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