Effects of carotenoids on mitochondrial dysfunction

Journal article


Ademowo, S., Oyebode, O., Edward, R., Conway, M., Griffiths, H. and Dias, I. H. K. 2024. Effects of carotenoids on mitochondrial dysfunction. Biochemical Society Transactions. 52 (1), p. 65–74. https://doi.org/10.1042/BST20230193
AuthorsAdemowo, S., Oyebode, O., Edward, R., Conway, M., Griffiths, H. and Dias, I. H. K.
Abstract

Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrial-derived ROS are associated with mitochondrial dysfunction, an early event in age-related diseases such as Alzheimer’s diseases (ADs) and in metabolic disorders including diabetes. AD post-mortem investigations of affected brain regions have shown the accumulation of oxidative damage to macromolecules, and oxidative stress has been considered
an important contributor to disease pathology. An increase in oxidative stress, which leads to increased levels of superoxide, hydrogen peroxide and other ROS in a potentially
vicious cycle is both causative and a consequence of mitochondrial dysfunction.
Mitochondrial dysfunction may be ameliorated by molecules with antioxidant capacities that accumulate in mitochondria such as carotenoids. However, the role of carotenoids in
mitigating mitochondrial dysfunction is not fully understood. A better understanding of the role of antioxidants in mitochondrial function is a promising lead towards the development of novel and effective treatment strategies for age-related diseases. This review evaluates and summarises some of the latest developments and insights into the effects
of carotenoids on mitochondrial dysfunction with a focus on the antioxidant properties of carotenoids. The mitochondria-protective role of carotenoids may be key in therapeutic
strategies and targeting the mitochondria ROS is emerging in drug development for age-related diseases.

KeywordsCarotenoids; oxidative stress; mitochondria; reactive oxygen species; astaxanthin
Year2024
JournalBiochemical Society Transactions
Journal citation52 (1), p. 65–74
PublisherPortland Press
ISSN1470-8752
Digital Object Identifier (DOI)https://doi.org/10.1042/BST20230193
Web address (URL)https://portlandpress.com/biochemsoctrans/article/52/1/65/234092/Effects-of-carotenoids-on-mitochondrial
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Output statusPublished
Publication dates
Online22 Feb 2024
Publication process dates
Accepted08 Feb 2024
Deposited04 Mar 2024
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