Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients

Journal article


Ademowo, O.S., Dias, H.K.I., Milic, I., Devitt, A., Moran, R., Mulcahy, R., Howard, A.N., Nolan, J.M. and Griffiths, H.R. 2017. Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients. Free Radical Biology and Medicine. 108, pp. 77-85. https://doi.org/10.1016/j.freeradbiomed.2017.03.008
AuthorsAdemowo, O.S., Dias, H.K.I., Milic, I., Devitt, A., Moran, R., Mulcahy, R., Howard, A.N., Nolan, J.M. and Griffiths, H.R.
Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease, characterised by decline of memory, cognitive function and changes in behaviour. Generic markers of lipid peroxidation are increased in AD and reactive oxygen species have been suggested to be involved in the aetiology of cognitive decline. Carotenoids are depleted in AD serum, therefore we have compared serum lipid oxidation between AD and age-matched control subjects before and after carotenoid supplementation. The novel oxidised phospholipid biomarker 1-palmitoyl-2-(5′-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC) was analysed using electrospray ionisation tandem mass spectrometry (MS) with multiple reaction monitoring (MRM), 8-isoprostane (IsoP) was measured by ELISA and ferric reducing antioxidant potential (FRAP) was measured by a colorimetric assay. AD patients (n=21) and healthy age-matched control subjects (n=16) were supplemented with either Macushield™ (10 mg meso-zeaxanthin, 10 mg lutein, 2 mg zeaxanthin) or placebo (sunflower oil) for six months. The MRM-MS method determined serum POVPC sensitively (from 10 µl serum) and reproducibly (CV=7.9%). At baseline, AD subjects had higher serum POVPC compared to age-matched controls, (p=0.017) and cognitive function was correlated inversely with POVPC (r=−0.37; p=0.04). After six months of carotenoid intervention, serum POVPC was not different in AD patients compared to healthy controls. However, POVPC was significantly higher in control subjects after six months of carotenoid intervention compared to their baseline (p=0.03). Serum IsoP concentration was unrelated to disease or supplementation. Serum FRAP was significantly lower in AD than healthy controls but was unchanged by carotenoid intervention (p=0.003). In conclusion, serum POVPC is higher in AD patients compared to control subjects, is not reduced by carotenoid supplementation and correlates with cognitive function.

KeywordsOxidative stres; Lipid Peroxidation; POVPC; Mass spectrometry; Lutein; Meso-zeaxanthin; Zeaxanthin; Supplementation; Cognitive function
Year2017
JournalFree Radical Biology and Medicine
Journal citation108, pp. 77-85
PublisherElsevier BV
ISSN0891-5849
Digital Object Identifier (DOI)https://doi.org/10.1016/j.freeradbiomed.2017.03.008
Web address (URL)http://hdl.handle.net/10545/624539
https://www.elsevier.com/tdm/userlicense/1.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
hdl:10545/624539
Publication dates14 Mar 2017
Publication process dates
Deposited05 Mar 2020, 09:20
Accepted11 Mar 2017
Rights

© 2017 The Authors. Published by Elsevier Inc.

Attribution-NonCommercial-NoDerivatives 4.0 International

ContributorsAston University Birmingham, Waterford Institute of Technology, Ireland, Waterford University Hospital, Ireland, University of Cambridge and University of Surrey
File
File Access Level
Open
File
File Access Level
Open
Permalink -

https://repository.derby.ac.uk/item/94q36/phospholipid-oxidation-and-carotenoid-supplementation-in-alzheimer-s-disease-patients

Download files

  • 37
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine
Ademowo, S., Wenk, M. R. and Maier, A. B. 2024. Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine. Ageing Research Reviews. 100, pp. 1-8. https://doi.org/10.1016/j.arr.2024.102432
Effects of carotenoids on mitochondrial dysfunction
Ademowo, S., Oyebode, O., Edward, R., Conway, M., Griffiths, H. and Dias, I. H. K. 2024. Effects of carotenoids on mitochondrial dysfunction. Biochemical Society Transactions. 52 (1), p. 65–74. https://doi.org/10.1042/BST20230193
Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis
Ademowo, OS. and Dias, I. H. K 2022. Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis. Redox Experimental Medicine. 2022 (1), pp. 116 -126. https://doi.org/10.1530/REM-22-0009
Inflammation, lipid (per)oxidation, and redox regulation
Dias, Irundika H.K., Milic, Ivana, Heiss, Christian, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew and Griffiths, Helen R. 2020. Inflammation, lipid (per)oxidation, and redox regulation. Antioxidant and Redox Signaling. https://doi.org/10.1089/ars.2020.8022
Nutritional hormesis in a modern environment
Ademowo, O. Stella, Dias, H. K. Irundika, Pararasa, Chathyan and Griffiths, Helen R. 2018. Nutritional hormesis in a modern environment. in: The Science of Hormesis in Health and Longevity Elsevier.
Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis
Ademowo, Opeyemi S, Hernandez, Belinda, Collins, Emily, Rooney, Cathy, Fearon, Ursula, van Kuijk, Arno W, Tak, Paul-P, Gerlag, Danielle M, FitzGerald, Oliver and Pennington, Stephen R 2014. Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Annals of the Rheumatic Diseases. 75 (1), pp. 234-241. https://doi.org/10.1136/annrheumdis-2014-205417
Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids
Ademowo, Opeyemi S., Dias, Irundika H.K., Diaz-Sanchez, Lorena, Sanchez-Aranguren, Lissette, Stahl, Wilhelm and Griffiths, Helen R. 2020. Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-190923
Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity
Ademowo, Opeyemi Stella, Sharma, Praveen, Cockwell, Paul, Reis, Ana, Chapple, Iain L., Griffiths, Helen R. and Dias, Irundika H.K. 2019. Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity. Free Radical Biology and Medicine. 146, pp. 130-138. https://doi.org/10.1016/j.freeradbiomed.2019.10.012
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Ademowo, O. S., Dias, H. K. I., Burton, D. G. A. and Griffiths, H. R. 2017. Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? Biogerontology. 18 (6), pp. 859-879. https://doi.org/10.1007/s10522-017-9710-z
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio and Daiber, Andreas 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13, pp. 94-162. https://doi.org/10.1016/j.redox.2017.05.007