Nutritional hormesis in a modern environment

Book chapter


Ademowo, O. Stella, Dias, H. K. Irundika, Pararasa, Chathyan and Griffiths, Helen R. 2018. Nutritional hormesis in a modern environment. in: The Science of Hormesis in Health and Longevity Elsevier.
AuthorsAdemowo, O. Stella, Dias, H. K. Irundika, Pararasa, Chathyan and Griffiths, Helen R.
Abstract

Nutrition is a powerful determinant of health and well-being. In the modern environment where energy-rich foods are prevalent, challenges exist to improve diets that will provide an appropriate energy density while maintaining the required nutritional value. A recent concept in nutrition is that components of food which are not abundant in the diet may exert a regulatory effect on physiological and biological processes. Some of these components appear to act as hormetins, i.e., they exert a mild stress and in turn elicit and adaptive response that offers greater health advantages than the stress itself. Therefore, nutritional hormesis play a vital role in the modern aging population by modulating the susceptibility to diseases. Adequate and appropriate dietary levels of hormetic phytochemicals; polyphenols, carotenoids, sulforaphane, and other bioactive compounds have been recognized as activators of intracellular signaling cascades and modifiers of gene expression with health benefits. Research to date has focused on individual hormetins in isolation, however, the bioavailability, bioaccessibility, and potential for interaction of these compounds in combination through acting on distinct intracellular signaling pathways are of significance in the human body. As the modern world’s population ages chronologically, yet biologically at different rates, it is increasingly important to understand how nutrition and hormetins within the diet could reduce risk for age-associated disease. Further work is needed in the field of nutrigenomics to identify the key biochemical targets that are modifiable by hormetins.

KeywordsNutrition; Phytochemicals; Hormesis; Oxidative stress; Antioxidant; Carotenoids; Polyphenols
Year2018
Book titleThe Science of Hormesis in Health and Longevity
PublisherElsevier
ISBN9780128142530
Digital Object Identifier (DOI)https://doi.org/10.1016/b978-0-12-814253-0.00006-1
Web address (URL)http://hdl.handle.net/10545/624646
https://www.elsevier.com/tdm/userlicense/1.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
hdl:10545/624646
File
File Access Level
Open
File
File Access Level
Open
Publication dates26 Oct 2018
Publication process dates
Deposited01 Apr 2020, 15:53
Accepted2018
Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

ContributorsAston University and University of Surrey
Permalink -

https://repository.derby.ac.uk/item/94y12/nutritional-hormesis-in-a-modern-environment

Download files


File
license.txt
File access level: Open

license_rdf
File access level: Open

  • 31
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis
Ademowo, OS. and Dias, I. H. K 2022. Circulating oxysterols in Alzheimer’s disease: a systematic review and meta-analysis. Redox Experimental Medicine. 2022 (1), pp. 116 -126. https://doi.org/10.1530/REM-22-0009
Inflammation, lipid (per)oxidation, and redox regulation
Dias, Irundika H.K., Milic, Ivana, Heiss, Christian, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew and Griffiths, Helen R. 2020. Inflammation, lipid (per)oxidation, and redox regulation. Antioxidant and Redox Signaling. https://doi.org/10.1089/ars.2020.8022
Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis
Ademowo, Opeyemi S, Hernandez, Belinda, Collins, Emily, Rooney, Cathy, Fearon, Ursula, van Kuijk, Arno W, Tak, Paul-P, Gerlag, Danielle M, FitzGerald, Oliver and Pennington, Stephen R 2014. Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Annals of the Rheumatic Diseases. 75 (1), pp. 234-241. https://doi.org/10.1136/annrheumdis-2014-205417
Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids
Ademowo, Opeyemi S., Dias, Irundika H.K., Diaz-Sanchez, Lorena, Sanchez-Aranguren, Lissette, Stahl, Wilhelm and Griffiths, Helen R. 2020. Partial mitigation of oxidized phospholipid-mediated mitochondrial dysfunction in neuronal cells by oxocarotenoids. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-190923
Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity
Ademowo, Opeyemi Stella, Sharma, Praveen, Cockwell, Paul, Reis, Ana, Chapple, Iain L., Griffiths, Helen R. and Dias, Irundika H.K. 2019. Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity. Free Radical Biology and Medicine. 146, pp. 130-138. https://doi.org/10.1016/j.freeradbiomed.2019.10.012
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Ademowo, O. S., Dias, H. K. I., Burton, D. G. A. and Griffiths, H. R. 2017. Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? Biogerontology. 18 (6), pp. 859-879. https://doi.org/10.1007/s10522-017-9710-z
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio and Daiber, Andreas 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13, pp. 94-162. https://doi.org/10.1016/j.redox.2017.05.007
Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients
Ademowo, O.S., Dias, H.K.I., Milic, I., Devitt, A., Moran, R., Mulcahy, R., Howard, A.N., Nolan, J.M. and Griffiths, H.R. 2017. Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients. Free Radical Biology and Medicine. 108, pp. 77-85. https://doi.org/10.1016/j.freeradbiomed.2017.03.008