Multilayered composite coatings of titanium dioxide nanotubes decorated with zinc oxide and hydroxyapatite nanoparticles: controlled release of Zn and antimicrobial properties against <em>Staphylococcus aureus</em></p>
Journal article
Gunputh, Urvashi Fowdar, Le, Huirong, Besinis, Alexandros, Tredwin, Christopher and Handy, Richard 2019. Multilayered composite coatings of titanium dioxide nanotubes decorated with zinc oxide and hydroxyapatite nanoparticles: controlled release of Zn and antimicrobial properties against <em>Staphylococcus aureus</em></p>. International Journal of Nanomedicine. Volume 14, pp. 3583-3600. https://doi.org/10.2147/ijn.s199219
| Authors | Gunputh, Urvashi Fowdar, Le, Huirong, Besinis, Alexandros, Tredwin, Christopher and Handy, Richard |
|---|---|
| Abstract | This study aimed to decorate the surface of TiO2 nanotubes (TiO2 NTs) grown on medical grade Ti-6Al-4V alloy with an antimicrobial layer of nano zinc oxide particles (nZnO) and then determine if the antimicrobial properties were maintained with a final layer of nano-hydroxyapatite (HA) on the composite. The additions of nZnO were attempted at three different annealing temperatures: 350, 450 and 550 °C. Of these temperatures, 350°C provided the most uniform and nanoporous coating and was selected for antimicrobial testing. The LIVE/DEAD assay showed that ZnCl2 and nZnO alone were >90% biocidal to the attached bacteria, and nZnO as a coating on the nanotubes resulted in around 70% biocidal activity. The lactate production assay agreed with the LIVE/DEAD assay. The concentrations of lactate produced by the attached bacteria on the surface of nZnO-coated TiO2 NTs and ZnO/HA-coated TiO2 NTs were 0.13±0.03 mM and 0.37±0.1 mM, respectively, which was significantly lower than that produced by the bacteria on TiO2 NTs alone, 1.09±0.30 mM (Kruskal–Wallis, P<0.05, n=6). These biochemical measurements were correlated with electron micrographs of cell morphology and cell coverage on the coatings. nZnO on TiO2 NTs was a stable and antimicrobial coating, and most of the biocidal properties remained in the presence of nano-HA on the coating. |
| Keywords | Biophysics; Organic Chemistry; Bioengineering; Drug Discovery; Biomaterials; General Medicine |
| Year | 2019 |
| Journal | International Journal of Nanomedicine |
| Journal citation | Volume 14, pp. 3583-3600 |
| Publisher | Dove Medical Press Ltd. |
| ISSN | 11782013 |
| Digital Object Identifier (DOI) | https://doi.org/10.2147/ijn.s199219 |
| Web address (URL) | http://hdl.handle.net/10545/624192 |
| http://creativecommons.org/publicdomain/zero/1.0/ | |
| hdl:10545/624192 | |
| Publication dates | 16 May 2019 |
| Publication process dates | |
| Deposited | 07 Oct 2019, 13:52 |
| Accepted | 21 Mar 2019 |
| Rights | CC0 1.0 Universal |
| Contributors | University of Derby and Plymouth University |
| File | File Access Level Open |
| File | File Access Level Open |
| File | File Access Level Open |
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