Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea)

Journal article


Sal, F., Prados, J. and Urcelay, G. P. 2021. Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea). Pharmacology, Biochemistry and Behavior. 200, pp. 1-12. https://doi.org/10.1016/j.pbb.2020.173075
AuthorsSal, F., Prados, J. and Urcelay, G. P.
Abstract

Chronic nicotine exposure reduces sensitivity to the effects of nicotine, which then results in behavioural changes and tolerance development. In the planaria, a valuable first-stage preclinical model for addictive behaviour, acute nicotine administration has been shown to steadily alter the motility of the animals, a result that has been interpreted as evidence of tolerance and withdrawal effects; however, chronic exposure - typically regarded as a condition for the development of tolerance - and the role of the contextual cues have not been systematically assessed. The present study assessed the acute and chronic effects of nicotine on the motility of planarians (Schmidtea mediterranea). The animals in the experimental groups received long chronic exposure to nicotine (ten daily 30 min exposures); a control group was exposed to water in the same context but in the absence of the drug. The motility of the animals was closely monitored on every exposure. Following this phase, all the animals were subject to three different tests: in the presence of the exposure context (without the drug, Test 1); in the presence of nicotine in the exposure context (Test 2); and in the presence of the drug in a novel context (Test 3). Exposure to nicotine consistently reduced motility; the motility in the presence of nicotine increased with repeated exposures to the drug, an instance of tolerance development. Tolerance development was dependent on nicotinic receptor activation, because it was blocked by the co-administration of mecamylamine. However, this tolerance was found to be independent of the contextual cues where the effects of the drug had been experienced. The results are discussed by reference to the existent theories of tolerance development to drugs.

KeywordsPlanaria; Nicotine ; Addiction
Year2021
JournalPharmacology, Biochemistry and Behavior
Journal citation200, pp. 1-12
PublisherElsevier
ISSN0091-3057
Digital Object Identifier (DOI)https://doi.org/10.1016/j.pbb.2020.173075
Web address (URL)https://www.sciencedirect.com/science/article/pii/S0091305720304664?casa_token=cUNNRF2g62UAAAAA:Q5KuX-E5HZ2yBrOtELvF-Angj3X_sW1g8RCSFR608R1pIlJC83Mxmj_ocq2WbJbfeturAzX4Ag
https://leicester.figshare.com/articles/journal_contribution/Nicotine_chronic_tolerance_development_and_withdrawal_in_the_planaria_Schmidtea_mediterranea_/13318643
Publisher's version
Publication dates24 Nov 2020
Publication process dates
Accepted16 Nov 2020
Deposited30 Aug 2022
Permalink -

https://repository.derby.ac.uk/item/98468/nicotine-chronic-tolerance-development-and-withdrawal-in-the-planaria-schmidtea-mediterranea

Download files

  • 14
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Avoidance Learning in the planaria
Prados, J., Jordan, L., Alcala, J. A. and Urcelay, G. P. Avoidance Learning in the planaria.
Placebos: A Psychological and Biological Perspective
Prados, J. and Gibson, C. 2023. Placebos: A Psychological and Biological Perspective . in: Hall, C. (ed.) Introduction to Biological Psychology Sussex University of Sussex Library .
Temporal and spatial contiguity are necessary for competition between events
Herrera, Estibaliz, Alcalá, J. A., Tazumi, T., Buckley, M. G., Prados, J. and Urcelay, G. P. 2022. Temporal and spatial contiguity are necessary for competition between events. Journal of Experimental Psychology: Learning, Memory, and Cognition . 48 (3), pp. 321-347. https://doi.org/10.1037/xlm0001108
Temporal contiguity determines overshadowing and potentiation of human Action-Outcome performance
Alcalá, J.A., Kirkden, R.D., Bray, J., Prados, J. and Urcelay, G.P 2022. Temporal contiguity determines overshadowing and potentiation of human Action-Outcome performance. Psychonomic Bulletin & Review. pp. 1-12. https://doi.org/10.3758/s13423-022-02155-4
Mechanisms of Perceptual Learning: Prolonged Intermixed Pre-exposure Reduces the Effectiveness of the Unique and the Common Elements
Ballesta, S., Gordón, C., Prados, J. and Artigas, A. A 2021. Mechanisms of Perceptual Learning: Prolonged Intermixed Pre-exposure Reduces the Effectiveness of the Unique and the Common Elements. Journal of Experimental Psychology: Animal Learning and Cognition. 47 (1), pp. 36-47. https://doi.org/10.1037/xan0000279
Short- and long-term Habituation of photonegative and exploratory responses in the flatworm planaria (Dugesia)
Prados, J., Fisher, C., Moreno-Fernández, M.M., Tazumi, T. and Urcelay, G.P. 2020. Short- and long-term Habituation of photonegative and exploratory responses in the flatworm planaria (Dugesia). Journal of Experimental Psychology: Animal Learning and Cognition. 46 (3), pp. 354-365. https://doi.org/10.1037/xan0000256
Heat shock disrupts expression of excitatory and extinction memories in planaria: Interaction with amount of exposure
Turel, Z. B., Prados, J. and Urcelay, G. P. 2020. Heat shock disrupts expression of excitatory and extinction memories in planaria: Interaction with amount of exposure. Behavioural Processes. 179, pp. 1-9.. https://doi.org/10.1016/j.beproc.2020.104197
Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
Prados, J. 2017. Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian. Psychopharmacology. 235, pp. 829-836. https://doi.org/10.1007/s00213-017-4801-8