Heat shock disrupts expression of excitatory and extinction memories in planaria: Interaction with amount of exposure

Journal article


Turel, Z. B., Prados, J. and Urcelay, G. P. 2020. Heat shock disrupts expression of excitatory and extinction memories in planaria: Interaction with amount of exposure. Behavioural Processes. 179, pp. 1-9.. https://doi.org/10.1016/j.beproc.2020.104197
AuthorsTurel, Z. B., Prados, J. and Urcelay, G. P.
Abstract

In planarians, as seen in rodents, natural reinforcers (sucrose) and drugs of abuse support Conditioned Place Preference (CPP), which is a form of Pavlovian learning to examine the rewarding effects of natural reinforcers and drugs of abuse. Using this preparation, we have previously observed acquisition, extinction and reinstatement of sucrose CPP. In the present experiments, we used planaria to investigate the amnestic effects of Heat Shock (HS, a known stressor in planaria) following different amounts of CPP extinction sessions. Experiment 1 showed that planarians developed a CPP response to a sucrose-paired surface. Heat shock, when given in conjunction with exposure to the sucrose-paired surface, produced amnesia as assessed by a subsequent sucrose reinstatement test. We interpreted that the amnesic effect of HS was due to HS affecting the dominant excitatory memory at the time of HS exposure. Thus, we hypothesized that after extensive extinction training (10 exposures), HS would lead to recovery from extinction (when the new inhibitory memory is dominant at the time of HS exposure). Experiment 2 explored this possibility and showed that given HS following 10 extinction sessions had no amnestic effect on the excitatory CPP response. In Experiment 3, we hypothesized that 16 extinction sessions would produce a stronger (and hence dominant) extinction inhibitory trace, which then would be vulnerable to HS. We observed that HS impaired the expression of the extinction memory following 16 exposures. These results reveal different effects of HS on CPP memories depending on the amount of extinction,
and are fully consistent with the literature using rodents and humans. In addition, they suggest that planaria is a promising pre-clinical model to assess fundamental memory processes.

Keywordsplanarians; conditioned place; rodents
Year2020
JournalBehavioural Processes
Journal citation179, pp. 1-9.
PublisherElsevier
ISSN0376-6357
Digital Object Identifier (DOI)https://doi.org/10.1016/j.beproc.2020.104197
Web address (URL)https://www.sciencedirect.com/science/article/pii/S0376635720302643
https://leicester.figshare.com/articles/journal_contribution/Heat_shock_disrupts_expression_of_excitatory_and_extinction_memories_in_planaria_Interaction_with_amount_of_exposure/12881564
Output statusPublished
Publication dates
Online15 Jul 2020
Publication process dates
Accepted13 Jul 2020
Deposited30 Aug 2022
Supplemental file
Permalink -

https://repository.derby.ac.uk/item/9846q/heat-shock-disrupts-expression-of-excitatory-and-extinction-memories-in-planaria-interaction-with-amount-of-exposure

Download files

  • 36
    total views
  • 14
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Overshadowing and salience attribution in relation to cannabis use
Dawnes, C., McGreal, S. J., Marwaha, S., Prados, J., Reheis, A., Dumitrescu, A., Waddington, J. L., Moran, P. M. and O'Tuathaigh, C. 2024. Overshadowing and salience attribution in relation to cannabis use. Schizophrenia Research: Cognition. 37, pp. 1-9. https://doi.org/10.1016/j.scog.2024.100315
Avoidance Learning in the planaria
Prados, J., Jordan, L., Alcala, J. A. and Urcelay, G. P. Avoidance Learning in the planaria.
Disentangling the Evolution of Cognition: Learning in Cnidaria
Prados, J. 2023. Disentangling the Evolution of Cognition: Learning in Cnidaria . Learning and Behavior. pp. 1-2. https://doi.org/10.3758/s13420-023-00621-0
Further evidence for the role of temporal contiguity as a determinant of overshadowing
Alcala, J., Ogallar, P. M., Prados, J. and Urcelay, G. 2023. Further evidence for the role of temporal contiguity as a determinant of overshadowing. The Quarterly Journal of Experimental Psychology. pp. 1-45. https://doi.org/10.1177/17470218231197170
Placebos: A Psychological and Biological Perspective
Prados, J. and Gibson, C. 2023. Placebos: A Psychological and Biological Perspective . in: Hall, C. (ed.) Introduction to Biological Psychology Sussex University of Sussex Library .
Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders
Jordan, L., Alcala, J. A., Urcelay, G. P. and Prados, J. 2023. Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders. Behavioural Processes. 210, pp. 1-10. https://doi.org/10.1016/j.beproc.2023.104894
Category relevance attenuates overshadowing in human predictive learning
Alcalá, J. A., Prados, J. and Urcelay, G. P. 2023. Category relevance attenuates overshadowing in human predictive learning. Journal of Experimental Psychology: Animal Learning and Cognition. 49 (3), p. 162–178. https://doi.org/10.1037/xan0000357
Temporal and spatial contiguity are necessary for competition between events
Herrera, Estibaliz, Alcalá, J. A., Tazumi, T., Buckley, M. G., Prados, J. and Urcelay, G. P. 2022. Temporal and spatial contiguity are necessary for competition between events. Journal of Experimental Psychology: Learning, Memory, and Cognition . 48 (3), pp. 321-347. https://doi.org/10.1037/xlm0001108
Temporal contiguity determines overshadowing and potentiation of human Action-Outcome performance
Alcalá, J.A., Kirkden, R.D., Bray, J., Prados, J. and Urcelay, G.P 2022. Temporal contiguity determines overshadowing and potentiation of human Action-Outcome performance. Psychonomic Bulletin & Review. pp. 1-12. https://doi.org/10.3758/s13423-022-02155-4
Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea)
Sal, F., Prados, J. and Urcelay, G. P. 2021. Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea). Pharmacology, Biochemistry and Behavior. 200, pp. 1-12. https://doi.org/10.1016/j.pbb.2020.173075
Mechanisms of Perceptual Learning: Prolonged Intermixed Pre-exposure Reduces the Effectiveness of the Unique and the Common Elements
Ballesta, S., Gordón, C., Prados, J. and Artigas, A. A 2021. Mechanisms of Perceptual Learning: Prolonged Intermixed Pre-exposure Reduces the Effectiveness of the Unique and the Common Elements. Journal of Experimental Psychology: Animal Learning and Cognition. 47 (1), pp. 36-47. https://doi.org/10.1037/xan0000279
Short- and long-term Habituation of photonegative and exploratory responses in the flatworm planaria (Dugesia)
Prados, J., Fisher, C., Moreno-Fernández, M.M., Tazumi, T. and Urcelay, G.P. 2020. Short- and long-term Habituation of photonegative and exploratory responses in the flatworm planaria (Dugesia). Journal of Experimental Psychology: Animal Learning and Cognition. 46 (3), pp. 354-365. https://doi.org/10.1037/xan0000256
Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
Prados, J. 2017. Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian. Psychopharmacology. 235, pp. 829-836. https://doi.org/10.1007/s00213-017-4801-8