Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders

Journal article


Jordan, L., Alcala, J. A., Urcelay, G. P. and Prados, J. 2023. Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders. Behavioural Processes. 210, pp. 1-10. https://doi.org/10.1016/j.beproc.2023.104894
AuthorsJordan, L., Alcala, J. A., Urcelay, G. P. and Prados, J.
Abstract

The objective of the present study was to develop a model of avoidance learning and its extinction in planarians (Schmidtea mediterranea). Based on previous experiments showing conditioned place preference, we developed a procedure to investigate conditioned place avoidance (CPA) using shock as an unconditioned stimulus (US) and an automated tracking system to record the animals’ behaviour. In Experiment 1, we assessed the unconditioned properties of different shock intensities by measuring post shock activity. In two subsequent experiments we investigated CPA using different designs, surfaces as conditioned stimuli (CSs; rough and smooth), and different US intensities (5V and 10V). In general, we observed the successful development of CPA. However, CPA was stronger with higher shock intensities, and we found that, in our preparation, a rough surface is best at entering into an association with the shock than a smooth surface. Finally, we also observed extinction of CPA. The evidence of CPA and its extinction in flatworms validates the planaria as a pre-clinical model for the study of avoidance learning, a hallmark of anxiety disorders.

Keywordsanxiety-related disorders; model of avoidance learning; planarians
Year2023
JournalBehavioural Processes
Journal citation210, pp. 1-10
PublisherElsevier
ISSN0376-6357
Digital Object Identifier (DOI)https://doi.org/10.1016/j.beproc.2023.104894
Web address (URL)https://www.sciencedirect.com/science/article/pii/S0376635723000761
Accepted author manuscript
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Open
Publisher's version
File Access Level
Open
Output statusPublished
Publication dates
Online24 May 2023
Publication process dates
Accepted23 May 2023
Deposited05 Jun 2023
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