Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian

Journal article


Prados, J. 2017. Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian. Psychopharmacology. 235, pp. 829-836. https://doi.org/10.1007/s00213-017-4801-8
AuthorsPrados, J.
Abstract

In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals
showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system.

Keywords Planarian ; Sucrose addiction ; Conditioned place preference
Year2017
JournalPsychopharmacology
Journal citation235, pp. 829-836
PublisherSpringer
ISSN 1432-2072
Digital Object Identifier (DOI)https://doi.org/10.1007/s00213-017-4801-8
Web address (URL)https://link.springer.com/article/10.1007/s00213-017-4801-8
Publisher's version
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Open
Output statusPublished
Publication dates
Online02 Dec 2017
Publication process dates
Accepted26 Nov 2017
Deposited30 Aug 2022
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