Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice
Journal article
Parthsarathy, V., McLaughlin, C.M, Sharkey, S.J, Harnedy-Rothwell, P.A, Lafferty, R.A, Allsopp, P.J, McSorley, E.M, Fitzgerald, R.J and O'Harte, F.P.M 2021. Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice. Journal of Food Bioactives. 16, pp. 48-57. https://doi.org/10.31665/JFB.2021.16292
| Authors | Parthsarathy, V., McLaughlin, C.M, Sharkey, S.J, Harnedy-Rothwell, P.A, Lafferty, R.A, Allsopp, P.J, McSorley, E.M, Fitzgerald, R.J and O'Harte, F.P.M |
|---|---|
| Abstract | There is increasing interest in dietary protein for management of Type 2 diabetes mellitus (T2DM) and obesity. The effects of twice-daily oral administration of a salmon skin gelatin hydrolysate (SSGH, 50 mg/kg), boarfish protein hydrolysate (BPH, (50 mg/kg), metformin (200 mg/kg), or saline control, were investigated in ob/ob mice. Non-fasting blood glucose was significantly reduced with SSGH (p < 0.01), BPH (p < 0.001) and metformin (p < 0.001), which were reflected in reductions in glycated haemoglobin (HbA1c) (p < 0.001, p < 0.01 and p < 0.01, respectively). Responses to oral and intraperitoneal glucose tolerance were improved (p < 0.05–0.01), as well as circulating plasma lipid profiles (p < 0.05–0.001). Chronic BPH treatment increased circulating plasma insulin (p < 0.01), whereas SSGH improved insulin sensitivity (p < 0.05), versus respective controls. All treatments significantly reduced energy intake (p < 0.05–0.001) versus (ob/ob) controls, without affecting overall bodyweight. These findings suggest that fish hydrolysates mediate potent anti-diabetic actions similar to metformin and might be suitable for the management and prevention of T2DM. |
| Keywords | Boarfis; Blood glucose; Functional food |
| Year | 2021 |
| Journal | Journal of Food Bioactives |
| Journal citation | 16, pp. 48-57 |
| Publisher | International Society for Nutraceuticals and Functional Foods |
| ISSN | 2637-8752 |
| 2637-8779 | |
| Digital Object Identifier (DOI) | https://doi.org/10.31665/JFB.2021.16292 |
| Web address (URL) | http://www.isnff-jfb.com/index.php/JFB/article/view/260/427 |
| Funder | Department for Education |
| Accepted author manuscript | |
| Output status | Published |
| Publication dates | |
| Online | 31 Dec 2021 |
| Publication process dates | |
| Accepted | 23 Dec 2021 |
| Deposited | 19 Dec 2022 |
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https://repository.derby.ac.uk/item/9vz69/protein-hydrolysates-from-boarfish-capros-aper-and-atlantic-salmon-salmo-salar-skin-gelatin-improve-metabolic-control-in-genetically-obese-diabetic-ob-ob-mice
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