A Hybrid Strategy-based Ultra-narrow Stretchable Microelectrodes with Cell-level Resolution

Journal article


Li, F., Han, F., Wang, L., Huang, L., Samuel, O.W., Zhao, H., Xie, R., Wang, P., Tian, Q., Li, Q., Zhao, Y., Yu, Mei, Sun, J., Yang, R., Zhou, X., Li, F., Li, G., Lu, Y., Guo, P. and Liu, Z. 2023. A Hybrid Strategy-based Ultra-narrow Stretchable Microelectrodes with Cell-level Resolution. Advanced Functional Materials. 2300859, pp. 1-9. https://doi.org/10.1002/adfm.202300859
AuthorsLi, F., Han, F., Wang, L., Huang, L., Samuel, O.W., Zhao, H., Xie, R., Wang, P., Tian, Q., Li, Q., Zhao, Y., Yu, Mei, Sun, J., Yang, R., Zhou, X., Li, F., Li, G., Lu, Y., Guo, P. and Liu, Z.
Abstract

Stretchable ultra-narrow (e.g., 10 μm in width) microelectrodes are crucial for the electrophysiological monitoring of single cells providing the fundamental understanding to the working mechanism of neuro network or other electrically functional cells. Current fabrication strategies either focus on the preparation of normal stretchable electrodes with hundreds of micrometers or millimeters in width by using inorganic conductive materials or develop conductive organic polymer gel for ultra-narrow electrodes which suffer from low stretchability and instability for long-term implantation, therefore, it is still highly desirable to explore bio-interfacial ultra-narrow stretchable inorganic electrodes. Herein, we report a hybrid strategy to prepare ultra-narrow multi-channel stretchable microelectrodes without using photolithography or laser-assisting etching. A 10 μm × 10 μm monitoring window is fabricated with enhanced interfacial impedance by the special rough surface. The stretchability achieves to 120% for this 10 μm-width stretchable electrode. Supported by these superior properties, we demonstrate that the stretchable microelectrodes can detect electrophysiological signals of single cells in vitro and collect electrophysiological signals more precisely in vivo. The reported strategy would open up the accessible preparation of the fine-size stretchable microelectrode. It will significantly improve the resolution of monitoring and stimulation of inorganic stretchable electrodes.

KeywordsSingle Cell Bio-signal Monitoring ; Electrophysiology; Inorganic Conductive Materials; Stretchable Microelectrodes; Ultra-narrow Microelectrodes
Year2023
JournalAdvanced Functional Materials
Journal citation2300859, pp. 1-9
PublisherWiley
ISSN616-3028
Digital Object Identifier (DOI)https://doi.org/10.1002/adfm.202300859
Web address (URL)https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202300859
Accepted author manuscript
License
All rights reserved (under embargo)
File Access Level
Controlled
Output statusPublished
Publication dates
Online16 Apr 2023
Publication process dates
Accepted31 Mar 2023
Deposited22 Jun 2023
Supplemental file
File Access Level
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