Caenorhabditis elegans, a model organism for investigating immunity.

Journal article


Marsh, Elizabeth K and May, Robin C 2012. Caenorhabditis elegans, a model organism for investigating immunity. Applied and Environmental Microbiology. https://doi.org/10.1128/AEM.07486-11
AuthorsMarsh, Elizabeth K and May, Robin C
Abstract

The nematode Caenorhabditis elegans has been a powerful experimental organism for almost half a century. Over the past 10 years, researchers have begun to exploit the power of C. elegans to investigate the biology of a number of human pathogens. This work has uncovered mechanisms of host immunity and pathogen virulence that are analogous to those involved during pathogenesis in humans or other animal hosts, as well as novel immunity mechanisms which appear to be unique to the worm. More recently, these investigations have uncovered details of the natural pathogens of C. elegans, including the description of a novel intracellular microsporidian parasite as well as new nodaviruses, the first identification of viral infections of this nematode. In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens.

KeywordsC. elegans; Innate Immunity
Year2012
JournalApplied and Environmental Microbiology
ISSN1098-5336
Digital Object Identifier (DOI)https://doi.org/10.1128/AEM.07486-11
Web address (URL)http://hdl.handle.net/10545/623878
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
hdl:10545/623878
Publication dates09 Mar 2012
Publication process dates
Deposited14 Jun 2019, 12:37
Accepted27 Jan 2012
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Attribution-NonCommercial-NoDerivs 3.0 United States

ContributorsUniversity of Birmingham
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