Human Papillomavirus as a Risk Factor for Oropharyngeal Squamous Cell Carcinoma

Book chapter


Marsh, E. 2022. Human Papillomavirus as a Risk Factor for Oropharyngeal Squamous Cell Carcinoma. in: Harding, J. J. (ed.) Care of Head and Neck Cancer Patients for Dental Hygienists and Dental Therapists Oxford Wiley. pp. 36-43
AuthorsMarsh, E.
EditorsHarding, J. J.
Abstract

Most human papillomavirus (HPV) infections are low risk; some are even asymptomatic, whilst others cause benign papillomas, although these papillomas can persist over time and can be challenging to limit in immunocompromised individuals. For the past 20 years or so, the incidence of a subset of head and neck cancers (HNCs), oropharyngeal squamous cell carcinoma (OPSCC), primarily in the palatine and lingual tonsils, has been increasing in the UK and across the world. Whilst oral HPV is, in itself, a significant risk factor for HNC, there are other lifestyle factors that are associated with oral HPV infections and may also influence the persistence and oncogenic potential of the virus, thereby mediating the development of HPV-positive OPSCC. The most significant risk factor for HPV-mediated OPSCC is gender. The HPV vaccination programme for adolescent girls to reduce the incidence of cervical cancer was introduced across the world from 2007 and into the UK in 2008.

KeywordsHPV; Human Papillomavirus; Oropharyngeal Squamous Cell Carcinoma
Page range36-43
Year2022
Book titleCare of Head and Neck Cancer Patients for Dental Hygienists and Dental Therapists
PublisherWiley
Place of publicationOxford
ISBN9781119795001
Digital Object Identifier (DOI)https://doi.org/10.1002/9781119795032
Web address (URL)https://www.wiley.com/en-us/Care+of+Head+and+Neck+Cancer+Patients+for+Dental+Hygienists+and+Dental+Therapists-p-9781119795001
Output statusPublished
Publication dates
OnlineNov 2022
Publication process dates
Deposited07 Dec 2022
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https://repository.derby.ac.uk/item/9vv73/human-papillomavirus-as-a-risk-factor-for-oropharyngeal-squamous-cell-carcinoma

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